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• W1986767588 startingPage "e55345" @default.
• W1986767588 abstract "To gain insight into differences in placental physiology between two swine breeds noted for their dissimilar reproductive performance, that is, the Chinese Meishan and white composite (WC), we examined gene expression profiles of placental tissues collected at 25, 45, 65, 85, and 105 days of gestation by microarrays. Using a linear mixed model, a total of 1,595 differentially expressed genes were identified between the two pig breeds using a false-discovery rate q-value ≤0.05. Among these genes, we identified breed-specific isoforms of XIST, a long non-coding RNA responsible X-chromosome dosage compensation in females. Additionally, we explored the interaction of placental gene expression and chromosomal location by DIGMAP and identified three Sus scrofa X chromosomal bands (Xq13, Xq21, Xp11) that represent transcriptionally active clusters that differ between Meishan and WC during placental development. Also, pathway analysis identified fundamental breed differences in placental cholesterol trafficking and its synthesis. Direct measurement of cholesterol confirmed that the cholesterol content was significantly higher in the Meishan versus WC placentae. Taken together, this work identifies key metabolic pathways that differ in the placentae of two swine breeds noted for differences in reproductive prolificacy." @default.
• W1986767588 created "2016-06-24" @default.
• W1986767588 creator A5013721013 @default.
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• W1986767588 date "2013-01-31" @default.
• W1986767588 modified "2023-09-27" @default.
• W1986767588 title "Differences in X-Chromosome Transcriptional Activity and Cholesterol Metabolism between Placentae from Swine Breeds from Asian and Western Origins" @default.
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• W1986767588 doi "https://doi.org/10.1371/journal.pone.0055345" @default.
• W1986767588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3561265" @default.
• W1986767588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23383161" @default.
• W1986767588 hasPublicationYear "2013" @default.
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