Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986774920> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1986774920 endingPage "587" @default.
- W1986774920 startingPage "583" @default.
- W1986774920 abstract "The effect of pretreatment with heparin on lysis of arterial thrombi by tissue-type plasminogen activator (rt-PA) was studied in 19 dogs. Copper coil-induced carotid artery thrombi were weighed, inserted into the femoral arteries, and exposed to a 15 min infusion of rt-PA at 10 micrograms/kg/min either with (n = 6 thrombi) or without pretreatment with a 200 unit/kg bolus of heparin (n = 6 thrombi). The infusion of rt-PA without pretreatment reduced the thrombus weight by 27.6 +/- 7.4%, while infusion of rt-PA with pretreatment reduced it by 79.1 +/- 12.3% (p less than .0001). To test the hypothesis that heparin enhanced thrombolysis by preventing continued incorporation of new fibrin into the thrombus during thrombolysis we repeated the experiments using pretreatment with 8 U/kg of ancrod, which rapidly depletes fibrinogen. Pretreatment with ancrod (n = 6 thrombi) depleted fibrinogen and enhanced the lytic effect of rt-PA to a similar degree as pretreatment with heparin, resulting in a 67.6 +/- 12.3% (NS) decrease in thrombus weight. We conclude that heparin significantly enhances the thrombolytic effect of rt-PA, probably by preventing new fibrin formation and its incorporation into the thrombus during lysis." @default.
- W1986774920 created "2016-06-24" @default.
- W1986774920 creator A5008321815 @default.
- W1986774920 creator A5045955097 @default.
- W1986774920 creator A5053091456 @default.
- W1986774920 creator A5072758459 @default.
- W1986774920 creator A5080553568 @default.
- W1986774920 creator A5082589118 @default.
- W1986774920 date "1986-09-01" @default.
- W1986774920 modified "2023-10-18" @default.
- W1986774920 title "Enhancement of thrombolysis with tissue-type plasminogen activator by pretreatment with heparin." @default.
- W1986774920 cites W1590554910 @default.
- W1986774920 cites W1964405425 @default.
- W1986774920 cites W1978039741 @default.
- W1986774920 cites W2018064735 @default.
- W1986774920 cites W2023027803 @default.
- W1986774920 cites W2081336561 @default.
- W1986774920 cites W2087879171 @default.
- W1986774920 cites W2142993715 @default.
- W1986774920 cites W2157332499 @default.
- W1986774920 cites W2214576528 @default.
- W1986774920 cites W232058627 @default.
- W1986774920 cites W2402440509 @default.
- W1986774920 cites W2433010030 @default.
- W1986774920 cites W2467963347 @default.
- W1986774920 doi "https://doi.org/10.1161/01.cir.74.3.583" @default.
- W1986774920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3091287" @default.
- W1986774920 hasPublicationYear "1986" @default.
- W1986774920 type Work @default.
- W1986774920 sameAs 1986774920 @default.
- W1986774920 citedByCount "120" @default.
- W1986774920 countsByYear W19867749202014 @default.
- W1986774920 crossrefType "journal-article" @default.
- W1986774920 hasAuthorship W1986774920A5008321815 @default.
- W1986774920 hasAuthorship W1986774920A5045955097 @default.
- W1986774920 hasAuthorship W1986774920A5053091456 @default.
- W1986774920 hasAuthorship W1986774920A5072758459 @default.
- W1986774920 hasAuthorship W1986774920A5080553568 @default.
- W1986774920 hasAuthorship W1986774920A5082589118 @default.
- W1986774920 hasBestOaLocation W19867749201 @default.
- W1986774920 hasConcept C126322002 @default.
- W1986774920 hasConcept C203014093 @default.
- W1986774920 hasConcept C2776572282 @default.
- W1986774920 hasConcept C2777557582 @default.
- W1986774920 hasConcept C2779036427 @default.
- W1986774920 hasConcept C2779581417 @default.
- W1986774920 hasConcept C2779679481 @default.
- W1986774920 hasConcept C2779723990 @default.
- W1986774920 hasConcept C2780868729 @default.
- W1986774920 hasConcept C2781362458 @default.
- W1986774920 hasConcept C500558357 @default.
- W1986774920 hasConcept C54173615 @default.
- W1986774920 hasConcept C71924100 @default.
- W1986774920 hasConceptScore W1986774920C126322002 @default.
- W1986774920 hasConceptScore W1986774920C203014093 @default.
- W1986774920 hasConceptScore W1986774920C2776572282 @default.
- W1986774920 hasConceptScore W1986774920C2777557582 @default.
- W1986774920 hasConceptScore W1986774920C2779036427 @default.
- W1986774920 hasConceptScore W1986774920C2779581417 @default.
- W1986774920 hasConceptScore W1986774920C2779679481 @default.
- W1986774920 hasConceptScore W1986774920C2779723990 @default.
- W1986774920 hasConceptScore W1986774920C2780868729 @default.
- W1986774920 hasConceptScore W1986774920C2781362458 @default.
- W1986774920 hasConceptScore W1986774920C500558357 @default.
- W1986774920 hasConceptScore W1986774920C54173615 @default.
- W1986774920 hasConceptScore W1986774920C71924100 @default.
- W1986774920 hasIssue "3" @default.
- W1986774920 hasLocation W19867749201 @default.
- W1986774920 hasLocation W19867749202 @default.
- W1986774920 hasOpenAccess W1986774920 @default.
- W1986774920 hasPrimaryLocation W19867749201 @default.
- W1986774920 hasRelatedWork W1989931621 @default.
- W1986774920 hasRelatedWork W2032556115 @default.
- W1986774920 hasRelatedWork W2037064786 @default.
- W1986774920 hasRelatedWork W2081098696 @default.
- W1986774920 hasRelatedWork W2094046931 @default.
- W1986774920 hasRelatedWork W2107625046 @default.
- W1986774920 hasRelatedWork W2410057693 @default.
- W1986774920 hasRelatedWork W2410396521 @default.
- W1986774920 hasRelatedWork W3150274750 @default.
- W1986774920 hasRelatedWork W4248134206 @default.
- W1986774920 hasVolume "74" @default.
- W1986774920 isParatext "false" @default.
- W1986774920 isRetracted "false" @default.
- W1986774920 magId "1986774920" @default.
- W1986774920 workType "article" @default.