FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986794853> ?p ?o ?g. }

• W1986794853 endingPage "192" @default.
• W1986794853 startingPage "181" @default.
• W1986794853 abstract "Neurofilaments are central determinants of the diameter of myelinated axons. It is less clear whether neurofilaments serve other functional roles such as maintaining the structural integrity of axons over time. Here we show that an age-dependent axonal atrophy develops in the lumbar ventral roots of mice with a null mutation in the mid-sized neurofilament subunit (NF-M) but not in animals with a null mutation in the heavy neurofilament subunit (NF-H). Mice with null mutations in both genes develop atrophy in ventral and dorsal roots as well as a hind limb paralysis with aging. The atrophic process is not accompanied by significant axonal loss or anterior horn cell pathology. In the NF-M–null mutant atrophic ventral root, axons show an age-related depletion of neurofilaments and an increased ratio of microtubules/neurofilaments. By contrast, the preserved dorsal root axons of NF-M–null mutant animals do not show a similar depletion of neurofilaments. Thus, the lack of an NF-M subunit renders some axons selectively vulnerable to an age-dependent atrophic process. These studies argue that neurofilaments are necessary for the structural maintenance of some populations of axons during aging and that the NF-M subunit is especially critical." @default.
• W1986794853 created "2016-06-24" @default.
• W1986794853 creator A5002612058 @default.
• W1986794853 creator A5013995386 @default.
• W1986794853 creator A5016775860 @default.
• W1986794853 creator A5084958891 @default.
• W1986794853 date "1999-07-12" @default.
• W1986794853 modified "2023-10-16" @default.
• W1986794853 title "Age-Related Atrophy of Motor Axons in Mice Deficient in the Mid-Sized Neurofilament Subunit" @default.
• W1986794853 cites W1639403002 @default.
• W1986794853 cites W169938888 @default.
• W1986794853 cites W1878737378 @default.
• W1986794853 cites W1967024359 @default.
• W1986794853 cites W1974531647 @default.
• W1986794853 cites W1977432832 @default.
• W1986794853 cites W1979917955 @default.
• W1986794853 cites W1982792843 @default.
• W1986794853 cites W1985639823 @default.
• W1986794853 cites W1986234504 @default.
• W1986794853 cites W1987000950 @default.
• W1986794853 cites W1987177237 @default.
• W1986794853 cites W1987277509 @default.
• W1986794853 cites W1992805397 @default.
• W1986794853 cites W1997059459 @default.
• W1986794853 cites W1998238515 @default.
• W1986794853 cites W2001299036 @default.
• W1986794853 cites W2007434688 @default.
• W1986794853 cites W2011575330 @default.
• W1986794853 cites W2020847620 @default.
• W1986794853 cites W2026539859 @default.
• W1986794853 cites W2032985361 @default.
• W1986794853 cites W2037618397 @default.
• W1986794853 cites W2037788915 @default.
• W1986794853 cites W2040211889 @default.
• W1986794853 cites W2048862091 @default.
• W1986794853 cites W2053099819 @default.
• W1986794853 cites W2056955753 @default.
• W1986794853 cites W2067149524 @default.
• W1986794853 cites W2071434138 @default.
• W1986794853 cites W2073614451 @default.
• W1986794853 cites W2077623928 @default.
• W1986794853 cites W2082559694 @default.
• W1986794853 cites W2083544461 @default.
• W1986794853 cites W2090095487 @default.
• W1986794853 cites W2099287762 @default.
• W1986794853 cites W2116087886 @default.
• W1986794853 cites W2119297613 @default.
• W1986794853 cites W2131518907 @default.
• W1986794853 cites W2137672131 @default.
• W1986794853 cites W2145229125 @default.
• W1986794853 cites W2151448727 @default.
• W1986794853 cites W2151808208 @default.
• W1986794853 cites W2171602378 @default.
• W1986794853 cites W2178362796 @default.
• W1986794853 cites W3003216803 @default.
• W1986794853 cites W3152410314 @default.
• W1986794853 cites W4231681508 @default.
• W1986794853 doi "https://doi.org/10.1083/jcb.146.1.181" @default.
• W1986794853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2199745" @default.
• W1986794853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10402469" @default.
• W1986794853 hasPublicationYear "1999" @default.
• W1986794853 type Work @default.
• W1986794853 sameAs 1986794853 @default.
• W1986794853 citedByCount "63" @default.
• W1986794853 countsByYear W19867948532012 @default.
• W1986794853 countsByYear W19867948532013 @default.
• W1986794853 countsByYear W19867948532014 @default.
• W1986794853 countsByYear W19867948532015 @default.
• W1986794853 countsByYear W19867948532016 @default.
• W1986794853 countsByYear W19867948532017 @default.
• W1986794853 countsByYear W19867948532018 @default.
• W1986794853 countsByYear W19867948532020 @default.
• W1986794853 countsByYear W19867948532021 @default.
• W1986794853 countsByYear W19867948532023 @default.
• W1986794853 crossrefType "journal-article" @default.
• W1986794853 hasAuthorship W1986794853A5002612058 @default.
• W1986794853 hasAuthorship W1986794853A5013995386 @default.
• W1986794853 hasAuthorship W1986794853A5016775860 @default.
• W1986794853 hasAuthorship W1986794853A5084958891 @default.
• W1986794853 hasBestOaLocation W19867948531 @default.
• W1986794853 hasConcept C104292427 @default.
• W1986794853 hasConcept C104317684 @default.
• W1986794853 hasConcept C105702510 @default.
• W1986794853 hasConcept C157207234 @default.
• W1986794853 hasConcept C169760540 @default.
• W1986794853 hasConcept C203014093 @default.
• W1986794853 hasConcept C204232928 @default.
• W1986794853 hasConcept C2779530196 @default.
• W1986794853 hasConcept C2781172350 @default.
• W1986794853 hasConcept C54355233 @default.
• W1986794853 hasConcept C86803240 @default.
• W1986794853 hasConcept C95444343 @default.
• W1986794853 hasConceptScore W1986794853C104292427 @default.
• W1986794853 hasConceptScore W1986794853C104317684 @default.
• W1986794853 hasConceptScore W1986794853C105702510 @default.
• W1986794853 hasConceptScore W1986794853C157207234 @default.
• W1986794853 hasConceptScore W1986794853C169760540 @default.
• W1986794853 hasConceptScore W1986794853C203014093 @default.

• next