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• W1986798648 abstract "Vitamin supplementation is prescribed for renal failure patients, including dialysis patients, because restricted diet, uremic toxins, drug effects, and the process of dialysis increase the risk of frank or subclinical vitamin deficiency. The appropriate level of supplementation of folic acid has been controversial. The increased requirement for pyridoxine, vitamin B6, to normalize serum levels of its active moiety, pyridoxal phosphate, is generally unrecognized. Data are rapidly accumulating suggesting that vitamins B6 (pyridoxine) and B12 (cobalamin) as well as folic acid may play a protective role in cardiovascular disease. Homocysteine, an amino acid intermediate, is now generally accepted as a risk factor in vascular atherosclerosis and cardiovascular disease. Folic acid and vitamins B6 and B12 play a significant role in normalizing homocysteine metabolism, thereby preventing its accumulation in excessive amounts in blood and urine. Renal failure patients tend to have high serum homocysteine levels and a high rate of cardiovascular disease. Appropriate and as yet undefined levels of supplementation with folic acid, pyridoxine, and cobalamin may decrease the risk of cardiovascular disease related to the homocysteine risk factor." @default.
• W1986798648 created "2016-06-24" @default.
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• W1986798648 date "1996-01-01" @default.
• W1986798648 modified "2023-09-23" @default.
• W1986798648 title "Folic acid, pyridoxine, cobalamin, and homocysteine and their relationship to cardiovascular disease in end-stage renal disease" @default.
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• W1986798648 doi "https://doi.org/10.1016/s1051-2276(96)90102-8" @default.
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