FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986804595> ?p ?o ?g. }

• W1986804595 endingPage "250" @default.
• W1986804595 startingPage "243" @default.
• W1986804595 abstract "Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effectively used to treat motor symptoms in Parkinson's disease (PD). Recently more attention has been paid to behavioral disturbances caused by PD itself and by STN DBS. In the 6-hydroxydopamine (6-OHDA) PD rat model we investigated the effect of STN DBS on deficient prepulse inhibition (PPI) induced by the dopamine (DA) receptor agonist apomorphine, which is an operative measure for disturbed sensorimotor gating seen in certain neuropsychiatric disturbances. Male Sprague Dawley rats with bilateral lesions of the nigrostriatal DA system (striatal injection of 6-OHDA or vehicle for sham-lesion) were bilaterally implanted with electrodes for DBS into the STN. After determination of individual thresholds rats were stimulated (130 Hz, 80 μs pulse width) or sham-stimulated for epochs of six days. On the sixth day of each epoch rats were tested for PPI of the acoustic startle response after apomorphine or vehicle injection in a within randomized cross-over design. Stimulation of the STN improved PPI in vehicle-treated (control) rats, but deteriorated PPI after apomorphine treatment. This effect was more pronounced in sham-lesioned rats. Furthermore, in lesioned rats the startle reaction was marginally enhanced without effect of stimulation or apomorphine treatment. These data suggest that STN DBS interacts with dopaminergic action. With respect to functional neurosurgery, STN DBS alone may improve certain aspects of psychiatric disturbances, but may have a different impact when combined with dopaminergic medication." @default.
• W1986804595 created "2016-06-24" @default.
• W1986804595 creator A5044208679 @default.
• W1986804595 creator A5046369045 @default.
• W1986804595 creator A5064807613 @default.
• W1986804595 date "2012-04-01" @default.
• W1986804595 modified "2023-10-18" @default.
• W1986804595 title "Deep brain stimulation of the subthalamic nucleus in the 6-hydroxydopamine rat model of Parkinson's disease: Effects on sensorimotor gating" @default.
• W1986804595 cites W1516822224 @default.
• W1986804595 cites W1842341093 @default.
• W1986804595 cites W1948978305 @default.
• W1986804595 cites W1965191197 @default.
• W1986804595 cites W1965336013 @default.
• W1986804595 cites W1967282079 @default.
• W1986804595 cites W1967470860 @default.
• W1986804595 cites W1975180862 @default.
• W1986804595 cites W1975871574 @default.
• W1986804595 cites W1980967004 @default.
• W1986804595 cites W1982557385 @default.
• W1986804595 cites W1985174354 @default.
• W1986804595 cites W1994982044 @default.
• W1986804595 cites W1998566135 @default.
• W1986804595 cites W1998617934 @default.
• W1986804595 cites W2002920730 @default.
• W1986804595 cites W2005756201 @default.
• W1986804595 cites W2006621603 @default.
• W1986804595 cites W2006954834 @default.
• W1986804595 cites W2012920011 @default.
• W1986804595 cites W2015594248 @default.
• W1986804595 cites W2020092078 @default.
• W1986804595 cites W2020996348 @default.
• W1986804595 cites W2029277771 @default.
• W1986804595 cites W2029284138 @default.
• W1986804595 cites W2032471499 @default.
• W1986804595 cites W2039117076 @default.
• W1986804595 cites W2039151038 @default.
• W1986804595 cites W2042847262 @default.
• W1986804595 cites W2046545864 @default.
• W1986804595 cites W2050547591 @default.
• W1986804595 cites W2059631807 @default.
• W1986804595 cites W2060477532 @default.
• W1986804595 cites W2063179842 @default.
• W1986804595 cites W2063764383 @default.
• W1986804595 cites W2070716859 @default.
• W1986804595 cites W2074942168 @default.
• W1986804595 cites W2080212310 @default.
• W1986804595 cites W2081224446 @default.
• W1986804595 cites W2091474479 @default.
• W1986804595 cites W2099902873 @default.
• W1986804595 cites W2099975809 @default.
• W1986804595 cites W2105267783 @default.
• W1986804595 cites W2113151837 @default.
• W1986804595 cites W2123208606 @default.
• W1986804595 cites W2123984617 @default.
• W1986804595 cites W2132619376 @default.
• W1986804595 cites W2133562098 @default.
• W1986804595 cites W2133652459 @default.
• W1986804595 cites W2138198377 @default.
• W1986804595 cites W2140474378 @default.
• W1986804595 cites W2140791182 @default.
• W1986804595 cites W2146460333 @default.
• W1986804595 cites W2152069319 @default.
• W1986804595 cites W2152316935 @default.
• W1986804595 cites W2155620350 @default.
• W1986804595 cites W2156647835 @default.
• W1986804595 cites W2158482826 @default.
• W1986804595 cites W2161118302 @default.
• W1986804595 cites W2161325655 @default.
• W1986804595 cites W2414498655 @default.
• W1986804595 doi "https://doi.org/10.1016/j.bbr.2012.02.009" @default.
• W1986804595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22330948" @default.
• W1986804595 hasPublicationYear "2012" @default.
• W1986804595 type Work @default.
• W1986804595 sameAs 1986804595 @default.
• W1986804595 citedByCount "14" @default.
• W1986804595 countsByYear W19868045952014 @default.
• W1986804595 countsByYear W19868045952015 @default.
• W1986804595 countsByYear W19868045952016 @default.
• W1986804595 countsByYear W19868045952018 @default.
• W1986804595 countsByYear W19868045952019 @default.
• W1986804595 countsByYear W19868045952020 @default.
• W1986804595 countsByYear W19868045952021 @default.
• W1986804595 countsByYear W19868045952022 @default.
• W1986804595 crossrefType "journal-article" @default.
• W1986804595 hasAuthorship W1986804595A5044208679 @default.
• W1986804595 hasAuthorship W1986804595A5046369045 @default.
• W1986804595 hasAuthorship W1986804595A5064807613 @default.
• W1986804595 hasConcept C118552586 @default.
• W1986804595 hasConcept C126322002 @default.
• W1986804595 hasConcept C137183658 @default.
• W1986804595 hasConcept C137431309 @default.
• W1986804595 hasConcept C141421786 @default.
• W1986804595 hasConcept C15744967 @default.
• W1986804595 hasConcept C169760540 @default.
• W1986804595 hasConcept C24998067 @default.
• W1986804595 hasConcept C2776412080 @default.
• W1986804595 hasConcept C2777288102 @default.
• W1986804595 hasConcept C2777319143 @default.

• next