Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986804947> ?p ?o ?g. }
- W1986804947 endingPage "4305" @default.
- W1986804947 startingPage "4295" @default.
- W1986804947 abstract "Abstract Establishment of pregnancy in ruminants requires conceptus elongation and production of interferon-τ (IFNT), the pregnancy recognition signal that maintains ovarian progesterone (P4) production. These studies determined temporal and spatial alterations in IGF binding protein (IGFBP)-1 and IGFBP3 in the ovine and bovine uterus; effects of P4 and IFNT on their expression in the ovine uterus; and effects of IGFBP1 on ovine trophectoderm cell proliferation, migration, and attachment. IGFBP1 and IGFBP3 were studied because they are the only IGFBPs specifically expressed by the endometrial luminal epithelia in sheep. In sheep, IGFBP1 and IGFBP3 expression was coordinate with the period of conceptus elongation, whereas only IGFBP1 expression was coordinate with conceptus elongation in cattle. IGFBP1 mRNA in the ovine endometria was between 5- and 29-fold more abundant between d 12 and 16 of pregnancy compared with the estrous cycle and greater on d 16 of pregnancy than nonpregnancy in the bovine uterus. In sheep, P4 induced and IFNT stimulated expression of IGFBP1 but not IGFBP3; however, the effect of IFNT did not mimic the abundant increase observed in pregnant ewes. Therefore, IGFBP1 expression in the endometrium is regulated by another factor from the conceptus. IGFBP1 did not affect the proliferation of ovine trophectoderm cells in vitro but did stimulate their migration and mediate their attachment. These studies reveal that IGFBP1 is a common endometrial marker of conceptus elongation in sheep and cattle and most likely regulates conceptus elongation by stimulating migration and attachment of the trophectoderm." @default.
- W1986804947 created "2016-06-24" @default.
- W1986804947 creator A5016398070 @default.
- W1986804947 creator A5021286537 @default.
- W1986804947 creator A5043486744 @default.
- W1986804947 creator A5049231965 @default.
- W1986804947 creator A5064099505 @default.
- W1986804947 creator A5076315257 @default.
- W1986804947 creator A5081913822 @default.
- W1986804947 date "2009-06-04" @default.
- W1986804947 modified "2023-10-17" @default.
- W1986804947 title "Insulin-Like Growth Factor Binding Protein-1 in the Ruminant Uterus: Potential Endometrial Marker and Regulator of Conceptus Elongation" @default.
- W1986804947 cites W1494325196 @default.
- W1986804947 cites W1966904260 @default.
- W1986804947 cites W1970303208 @default.
- W1986804947 cites W1972584259 @default.
- W1986804947 cites W1976647192 @default.
- W1986804947 cites W1977100927 @default.
- W1986804947 cites W1979741190 @default.
- W1986804947 cites W1987724165 @default.
- W1986804947 cites W1988249861 @default.
- W1986804947 cites W1988576233 @default.
- W1986804947 cites W2003778314 @default.
- W1986804947 cites W2006340617 @default.
- W1986804947 cites W2011785882 @default.
- W1986804947 cites W2012099404 @default.
- W1986804947 cites W2012505775 @default.
- W1986804947 cites W2014418366 @default.
- W1986804947 cites W2021963506 @default.
- W1986804947 cites W2025483003 @default.
- W1986804947 cites W2026639574 @default.
- W1986804947 cites W2030933918 @default.
- W1986804947 cites W2031432118 @default.
- W1986804947 cites W2035650446 @default.
- W1986804947 cites W2044679654 @default.
- W1986804947 cites W2048307484 @default.
- W1986804947 cites W2067509038 @default.
- W1986804947 cites W2067986590 @default.
- W1986804947 cites W2070972898 @default.
- W1986804947 cites W2071110001 @default.
- W1986804947 cites W2073836271 @default.
- W1986804947 cites W2076145021 @default.
- W1986804947 cites W2076493903 @default.
- W1986804947 cites W2077285600 @default.
- W1986804947 cites W2078156035 @default.
- W1986804947 cites W2078981825 @default.
- W1986804947 cites W2080663383 @default.
- W1986804947 cites W2083943383 @default.
- W1986804947 cites W2088695582 @default.
- W1986804947 cites W2090171924 @default.
- W1986804947 cites W2090500747 @default.
- W1986804947 cites W2090615247 @default.
- W1986804947 cites W2093558134 @default.
- W1986804947 cites W2100272691 @default.
- W1986804947 cites W2100745995 @default.
- W1986804947 cites W2103842385 @default.
- W1986804947 cites W2105126882 @default.
- W1986804947 cites W2113650514 @default.
- W1986804947 cites W2114069082 @default.
- W1986804947 cites W2117870379 @default.
- W1986804947 cites W2121064319 @default.
- W1986804947 cites W2122778024 @default.
- W1986804947 cites W2126750542 @default.
- W1986804947 cites W2129522444 @default.
- W1986804947 cites W2132156533 @default.
- W1986804947 cites W2136035099 @default.
- W1986804947 cites W2136689179 @default.
- W1986804947 cites W2139585568 @default.
- W1986804947 cites W2140576646 @default.
- W1986804947 cites W2144722946 @default.
- W1986804947 cites W2145806560 @default.
- W1986804947 cites W2147995078 @default.
- W1986804947 cites W2155781584 @default.
- W1986804947 cites W2160548275 @default.
- W1986804947 cites W2160903592 @default.
- W1986804947 cites W2163229569 @default.
- W1986804947 cites W2164895413 @default.
- W1986804947 cites W2165006585 @default.
- W1986804947 cites W2165198770 @default.
- W1986804947 cites W2171656551 @default.
- W1986804947 cites W306937079 @default.
- W1986804947 cites W4256214420 @default.
- W1986804947 doi "https://doi.org/10.1210/en.2009-0060" @default.
- W1986804947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19497977" @default.
- W1986804947 hasPublicationYear "2009" @default.
- W1986804947 type Work @default.
- W1986804947 sameAs 1986804947 @default.
- W1986804947 citedByCount "58" @default.
- W1986804947 countsByYear W19868049472012 @default.
- W1986804947 countsByYear W19868049472013 @default.
- W1986804947 countsByYear W19868049472014 @default.
- W1986804947 countsByYear W19868049472015 @default.
- W1986804947 countsByYear W19868049472016 @default.
- W1986804947 countsByYear W19868049472017 @default.
- W1986804947 countsByYear W19868049472018 @default.
- W1986804947 countsByYear W19868049472019 @default.
- W1986804947 countsByYear W19868049472020 @default.
- W1986804947 countsByYear W19868049472021 @default.