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• W1986815766 abstract "Reports in the Journal over the past year have contributed new information on the benefits of systems management, indicators of disease activity, the role of allergy and infection in the development of asthma, and greater attention to evaluating and managing early asthma in children. The next steps include using this information to help identify young children at risk for asthma, applying early intervention with available therapies, and conducting further studies to identify more effective strategies to alter the course of the disease.Key advances in pediatric asthma in 2012•Periostin is a systemic biomarker of airway eosinophilia in asthmatic patients and has the potential utility in patient selection for emerging asthma therapies targeting TH2 inflammation.20Jia G. Erickson R.W. Choy D.F. Mosesova S. Wu L.C. Solberg O.W. et al.Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.J Allergy Clin Immunol. 2012; 130: 647-654Abstract Full Text Full Text PDF PubMed Scopus (82) Google Scholar•Epigenetic mechanisms provide a promising line of inquiry that might, in part, explain the inheritance and immunobiology of asthma.23Yang I.V. Schwartz D.A. Epigenetic mechanisms and the development of asthma.J Allergy Clin Immunol. 2012; 130: 1243-1255Abstract Full Text Full Text PDF PubMed Scopus (16) Google Scholar•Vitamin D supplementation might enhance corticosteroid responsiveness and control atopy and thereby improve asthma control in children.39Goleva E. Searing D.A. Jackson L.P. Richers B.N. Leung D.Y.M. Steroid requirements and immune associations with vitamin D are stronger in children than adults with asthma.J Allergy Clin Immunol. 2012; 129: 1243-1251Abstract Full Text Full Text PDF PubMed Scopus (40) Google Scholar•Airway epithelial cells from children with mild asthma exhibit greater expression of factors, including TGF-β, vascular endothelial growth factor, and periostin, associated with subepithelial airway remodeling than cells from atopic and healthy children.44Lopez-Guisa J.M. Powers C. File D. Cochrane E. Jimenez N. Debley J.S. Airway epithelial cells from asthmatic children differentially express proremodeling factors.J Allergy Clin Immunol. 2012; 129: 990-997Abstract Full Text Full Text PDF PubMed Scopus (28) Google Scholar•The National Institutes of Health (NIH) Asthma Outcomes Task Force provided a report on the definition of asthma outcomes that should be used in conducting NIH research.50Busse W.W. Morgan W.J. Taggart V. Togias A. Asthma outcomes workshop: overview.J Allergy Clin Immunol. 2012; 129: S1-S8Abstract Full Text Full Text PDF PubMed Google Scholar, 51Szefler S.J. Wenzel S. Brown R. Erzurum S.C. Fahy J.V. Hamilton R.G. et al.Asthma outcomes: biomarkers.J Allergy Clin Immunol. 2012; 129: S9-S23Abstract Full Text Full Text PDF PubMed Scopus (74) Google Scholar, 52Cloutier M.M. Schatz M. Castro M. Clark N. Kelly H.W. Mangione-Smith R. et al.Asthma outcomes: composite scores of asthma control.J Allergy Clin Immunol. 2012; 129: S24-S33Abstract Full Text Full Text PDF PubMed Scopus (45) Google Scholar, 53Fuhlbrigge A. Peden D. Apter A.J. Boushey H.A. Camargo C.A. Gern J. et al.Asthma outcomes: exacerbations.J Allergy Clin Immunol. 2012; 129: S34-S48Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar, 54Akinbami L.J. Sullivan S.D. Campbell J.D. Grundmeier R.W. Hartert T.V. Lee T.A. et al.Asthma outcomes: healthcare utilization and costs.J Allergy Clin Immunol. 2012; 129: S49-S64Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar, 55Tepper R.S. Wise R.S. Covar R. Irvin C.G. Kercsmar C.M. Kraft M. et al.Asthma outcomes: pulmonary physiology.J Allergy Clin Immunol. 2012; 129: S65-S87Abstract Full Text Full Text PDF PubMed Scopus (21) Google Scholar, 56Wilson S.R. Rand C.S. Cabana M.D. Foggs M.B. Halterman J.S. Olson L. et al.Asthma outcomes: quality of life.J Allergy Clin Immunol. 2012; 129: S88-S123Abstract Full Text Full Text PDF PubMed Scopus (24) Google Scholar, 57Krishnan J.A. Lemanske R.F. Canino G.J. Elward K.S. Kattan M. Matsui E.C. et al.Asthma outcomes: symptoms.J Allergy Clin Immunol. 2012; 129: S124-S135Abstract Full Text Full Text PDF PubMed Scopus (18) Google Scholar, 58Rand C.S. Wright R.J. Cabana M.D. Foggs M.B. Halterman J.S. Olson L. et al.Mediators of asthma outcomes.J Allergy Clin Immunol. 2012; 129: S136-S141Abstract Full Text Full Text PDF PubMed Scopus (17) Google Scholar•Lung function can be used to predict hospitalizations, emergency department visits, and need for oral corticosteroid therapy in pediatric patients.66Wu A.C. Gregory M. Kymes S. Lambert D. Edler J. Stwalley D. et al.Modeling asthma exacerbations through lung function in children.J Allergy Clin Immunol. 2012; 130: 1065-1070Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar•A significant pharmacogenetic interaction between anti–IL-4α therapy and IL4A gene variation is associated with a better response to therapy in reducing asthma exacerbations.76Slager R.E. Otulana B.A. Hawkins G.A. Yen Y.P. Peters S.P. Wenzel S.E. et al.IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist.J Allergy Clin Immunol. 2012; 130: 516-522Abstract Full Text Full Text PDF PubMed Scopus (34) Google Scholar•Dendritic cells could be a target for therapeutic intervention by influencing epithelial cell and dendritic cell interaction or blocking IgE receptor on dendritic cells and might alter antiviral response.100Gill M.A. The role of dendritic cells in asthma.J Allergy Clin Immunol. 2012; 129: 889-901Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar•Deficient interferon responses to rhinovirus infection are present in childhood in asthmatic patients irrespective of their atopic status and in atopic patients without asthma.117Baraldo S. Contoli M. Bazzan E. Turato G. Padovani A. Marku B. et al.Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma.J Allergy Clin Immunol. 2012; 130: 1307-1314Abstract Full Text Full Text PDF PubMed Scopus (26) Google Scholar•Deficits in lung function in childhood can persist into adulthood and perhaps put subjects at risk for the later development of chronic obstructive pulmonary disease.136Grad R. Morgan W.J. Long-term outcomes of early-onset wheeze and asthma.J Allergy Clin Immunol. 2012; 130: 299-307Abstract Full Text Full Text PDF PubMed Scopus (9) Google Scholar" @default.
• W1986815766 created "2016-06-24" @default.
• W1986815766 creator A5033765434 @default.
• W1986815766 date "2013-01-01" @default.
• W1986815766 modified "2023-10-16" @default.
• W1986815766 title "Advances in pediatric asthma in 2012: Moving toward asthma prevention" @default.
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