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• W1986823063 abstract "Abstract Objectives There have been no previous reports concerning functions of miR‐103a in gastric cancer ( GC ) cells. Thus the aim of the study was to investigate its expression and role in development of this tumour. Materials and methods Real‐time RT ‐ PCR was performed to detect expression of miR‐103a in GC cell lines and clinical cancer specimens. To further understand its role, we restored expression of miR‐103a in MGC‐803 cell line by transfection with miR‐103a mimics or inhibitors. Effects of miR‐103a on cell proliferation, migration and invasion on targets were also determined. Results miR‐103a was down‐regulated in both GC cell lines and clinical cancer specimens. Meanwhile, its level was closely associated with pM or pTNM stage of GC . Overexpression of miR‐103a markedly suppressed proliferation, migration, and invasion of GC cells, while its inhibition significantly accelerated cell proliferation, migration and invasion. Moreover, c‐Myb was identified to be a functional downstream target of miR‐103a, ectopic expression of which partially reversed suppression of cell proliferation and invasion. Conclusions Thus our observations suggest that miR‐103a functioned as a tumour suppressor by targeting c‐Myb. These findings indicate that miR‐103a might play a significant role in pathogenesis of GC." @default.
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• W1986823063 date "2014-12-22" @default.
• W1986823063 modified "2023-10-15" @default.
• W1986823063 title "MicroRNA-103a inhibits gastric cancer cell proliferation, migration and invasion by targeting c-Myb" @default.
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• W1986823063 doi "https://doi.org/10.1111/cpr.12159" @default.
• W1986823063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6496034" @default.
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