Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986823963> ?p ?o ?g. }
- W1986823963 endingPage "10" @default.
- W1986823963 startingPage "1" @default.
- W1986823963 abstract "About two thirds of all human breast cancer cases are estrogen receptor positive. The drug of first choice for these patients is tamoxifen. However, about half of the recurrences after removal of the primary tumor are or become resistant to this drug. While many mechanisms have been identified for tamoxifen resistance in the lab, at present only a few have been translated to the clinic. This paper highlights the role in tamoxifen resistance of phosphorylation by different kinases on different sites of the estrogen receptor. We will discuss the molecular pathways and kinases that are involved in phosphorylation of ERα and how these affect tamoxifen resistance. Finally, we will elaborate on the clinical translation of these observations and the possibility to predict tamoxifen responses in patient tumor samples before treatment onset. The findings made originally on the bench may translate into a better and personalized treatment of breast cancer patients using an old and safe anticancer drug: tamoxifen." @default.
- W1986823963 created "2016-06-24" @default.
- W1986823963 creator A5023741222 @default.
- W1986823963 creator A5060457244 @default.
- W1986823963 creator A5062007054 @default.
- W1986823963 date "2011-01-01" @default.
- W1986823963 modified "2023-10-14" @default.
- W1986823963 title "A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen" @default.
- W1986823963 cites W1493628203 @default.
- W1986823963 cites W1501286679 @default.
- W1986823963 cites W1966320080 @default.
- W1986823963 cites W1970755773 @default.
- W1986823963 cites W1973729526 @default.
- W1986823963 cites W1974334424 @default.
- W1986823963 cites W1981801066 @default.
- W1986823963 cites W1985453548 @default.
- W1986823963 cites W1991958056 @default.
- W1986823963 cites W1994511371 @default.
- W1986823963 cites W1996965514 @default.
- W1986823963 cites W2002339899 @default.
- W1986823963 cites W2005270454 @default.
- W1986823963 cites W2006216237 @default.
- W1986823963 cites W2013809140 @default.
- W1986823963 cites W2013956549 @default.
- W1986823963 cites W2016725598 @default.
- W1986823963 cites W2019502665 @default.
- W1986823963 cites W2023247746 @default.
- W1986823963 cites W2023384375 @default.
- W1986823963 cites W2033366396 @default.
- W1986823963 cites W2037913174 @default.
- W1986823963 cites W2050544607 @default.
- W1986823963 cites W2052639189 @default.
- W1986823963 cites W2058001287 @default.
- W1986823963 cites W2060123703 @default.
- W1986823963 cites W2065346432 @default.
- W1986823963 cites W2065958815 @default.
- W1986823963 cites W2068460762 @default.
- W1986823963 cites W2070092422 @default.
- W1986823963 cites W2071095686 @default.
- W1986823963 cites W2071901592 @default.
- W1986823963 cites W2072679779 @default.
- W1986823963 cites W2072787342 @default.
- W1986823963 cites W2075553098 @default.
- W1986823963 cites W2081491080 @default.
- W1986823963 cites W2083647855 @default.
- W1986823963 cites W2089595068 @default.
- W1986823963 cites W2090378553 @default.
- W1986823963 cites W2097349743 @default.
- W1986823963 cites W2097839570 @default.
- W1986823963 cites W2099647354 @default.
- W1986823963 cites W2100203276 @default.
- W1986823963 cites W2100980757 @default.
- W1986823963 cites W2105882193 @default.
- W1986823963 cites W2106353158 @default.
- W1986823963 cites W2106984286 @default.
- W1986823963 cites W2107982750 @default.
- W1986823963 cites W2108542713 @default.
- W1986823963 cites W2108681406 @default.
- W1986823963 cites W2110859653 @default.
- W1986823963 cites W2111650618 @default.
- W1986823963 cites W2116049905 @default.
- W1986823963 cites W2125772206 @default.
- W1986823963 cites W2132168822 @default.
- W1986823963 cites W2133850696 @default.
- W1986823963 cites W2134444110 @default.
- W1986823963 cites W2137355132 @default.
- W1986823963 cites W2137579997 @default.
- W1986823963 cites W2139522545 @default.
- W1986823963 cites W2140724756 @default.
- W1986823963 cites W2141232624 @default.
- W1986823963 cites W2141646633 @default.
- W1986823963 cites W2143185770 @default.
- W1986823963 cites W2155391261 @default.
- W1986823963 cites W2158717003 @default.
- W1986823963 cites W2159415114 @default.
- W1986823963 cites W2161550802 @default.
- W1986823963 cites W2164484108 @default.
- W1986823963 cites W2165313734 @default.
- W1986823963 cites W2171643283 @default.
- W1986823963 cites W4236886267 @default.
- W1986823963 cites W4246627793 @default.
- W1986823963 cites W4253138709 @default.
- W1986823963 doi "https://doi.org/10.4061/2011/232435" @default.
- W1986823963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3262574" @default.
- W1986823963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22295213" @default.
- W1986823963 hasPublicationYear "2011" @default.
- W1986823963 type Work @default.
- W1986823963 sameAs 1986823963 @default.
- W1986823963 citedByCount "84" @default.
- W1986823963 countsByYear W19868239632012 @default.
- W1986823963 countsByYear W19868239632013 @default.
- W1986823963 countsByYear W19868239632014 @default.
- W1986823963 countsByYear W19868239632015 @default.
- W1986823963 countsByYear W19868239632016 @default.
- W1986823963 countsByYear W19868239632017 @default.
- W1986823963 countsByYear W19868239632018 @default.
- W1986823963 countsByYear W19868239632019 @default.
- W1986823963 countsByYear W19868239632020 @default.