Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986826392> ?p ?o ?g. }
- W1986826392 endingPage "3165" @default.
- W1986826392 startingPage "3148" @default.
- W1986826392 abstract "Understanding the pathways by which viral capsid proteins assemble around their genomes could identify key intermediates as potential drug targets. In this work, we use computer simulations to characterize assembly over a wide range of capsid protein-protein interaction strengths and solution ionic strengths. We find that assembly pathways can be categorized into two classes, in which intermediates are either predominantly ordered or disordered. Our results suggest that estimating the protein-protein and the protein-genome binding affinities may be sufficient to predict which pathway occurs. Furthermore, the calculated phase diagrams suggest that knowledge of the dominant assembly pathway and its relationship to control parameters could identify optimal strategies to thwart or redirect assembly to block infection. Finally, analysis of simulation trajectories suggests that the two classes of assembly pathways can be distinguished in single-molecule fluorescence correlation spectroscopy or bulk time-resolved small-angle X-ray scattering experiments." @default.
- W1986826392 created "2016-06-24" @default.
- W1986826392 creator A5040320940 @default.
- W1986826392 creator A5071825352 @default.
- W1986826392 creator A5083616699 @default.
- W1986826392 date "2014-09-01" @default.
- W1986826392 modified "2023-09-30" @default.
- W1986826392 title "Pathways for Virus Assembly around Nucleic Acids" @default.
- W1986826392 cites W1582993742 @default.
- W1986826392 cites W1963600084 @default.
- W1986826392 cites W1966225171 @default.
- W1986826392 cites W1967765906 @default.
- W1986826392 cites W1968042570 @default.
- W1986826392 cites W1968475259 @default.
- W1986826392 cites W1973617853 @default.
- W1986826392 cites W1973659754 @default.
- W1986826392 cites W1981635966 @default.
- W1986826392 cites W1982115020 @default.
- W1986826392 cites W1983322280 @default.
- W1986826392 cites W1985166722 @default.
- W1986826392 cites W1985651475 @default.
- W1986826392 cites W1986801123 @default.
- W1986826392 cites W1986850267 @default.
- W1986826392 cites W1989164610 @default.
- W1986826392 cites W1990213830 @default.
- W1986826392 cites W1991056907 @default.
- W1986826392 cites W1991074394 @default.
- W1986826392 cites W1992815312 @default.
- W1986826392 cites W1994992677 @default.
- W1986826392 cites W1998940336 @default.
- W1986826392 cites W2001347103 @default.
- W1986826392 cites W2004114526 @default.
- W1986826392 cites W2005194304 @default.
- W1986826392 cites W2006696157 @default.
- W1986826392 cites W2006755239 @default.
- W1986826392 cites W2009264308 @default.
- W1986826392 cites W2014997764 @default.
- W1986826392 cites W2016260687 @default.
- W1986826392 cites W2016912251 @default.
- W1986826392 cites W2018008029 @default.
- W1986826392 cites W2025483135 @default.
- W1986826392 cites W2025512430 @default.
- W1986826392 cites W2026027178 @default.
- W1986826392 cites W2026677679 @default.
- W1986826392 cites W2029667189 @default.
- W1986826392 cites W2030886354 @default.
- W1986826392 cites W2033603249 @default.
- W1986826392 cites W2037065104 @default.
- W1986826392 cites W2039714174 @default.
- W1986826392 cites W2042223001 @default.
- W1986826392 cites W2043378904 @default.
- W1986826392 cites W2044978874 @default.
- W1986826392 cites W2051710479 @default.
- W1986826392 cites W2052076314 @default.
- W1986826392 cites W2052823487 @default.
- W1986826392 cites W2053914171 @default.
- W1986826392 cites W2056734463 @default.
- W1986826392 cites W2057038789 @default.
- W1986826392 cites W2058672131 @default.
- W1986826392 cites W2061551835 @default.
- W1986826392 cites W2062060027 @default.
- W1986826392 cites W2062617571 @default.
- W1986826392 cites W2062991184 @default.
- W1986826392 cites W2065537227 @default.
- W1986826392 cites W2066088601 @default.
- W1986826392 cites W2068771581 @default.
- W1986826392 cites W2072270959 @default.
- W1986826392 cites W2072614560 @default.
- W1986826392 cites W2073983708 @default.
- W1986826392 cites W2075663882 @default.
- W1986826392 cites W2077081693 @default.
- W1986826392 cites W2077253878 @default.
- W1986826392 cites W2078391824 @default.
- W1986826392 cites W2078604215 @default.
- W1986826392 cites W2079411557 @default.
- W1986826392 cites W2079732359 @default.
- W1986826392 cites W2081840485 @default.
- W1986826392 cites W2083579241 @default.
- W1986826392 cites W2087356131 @default.
- W1986826392 cites W2088020933 @default.
- W1986826392 cites W2090352063 @default.
- W1986826392 cites W2090720748 @default.
- W1986826392 cites W2091527323 @default.
- W1986826392 cites W2091634121 @default.
- W1986826392 cites W2095265942 @default.
- W1986826392 cites W2102548255 @default.
- W1986826392 cites W2102955467 @default.
- W1986826392 cites W2107516290 @default.
- W1986826392 cites W2111113395 @default.
- W1986826392 cites W2113074869 @default.
- W1986826392 cites W2113318971 @default.
- W1986826392 cites W2114259893 @default.
- W1986826392 cites W2116341881 @default.
- W1986826392 cites W2118250336 @default.
- W1986826392 cites W2118438578 @default.
- W1986826392 cites W2118897692 @default.
- W1986826392 cites W2119134320 @default.
- W1986826392 cites W2124012114 @default.