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- W1986840981 abstract "Brain injury associated preeclampsia (PE) may be occurred already in uterus, peri- and intraventricular echodensities can be detected in fetuses with uteroplacental insufficiency. Prematurity, hypoxia, ischemia and inflammation are clinical factors that predispose to perinatal brain damage but when and how they act, it is unclear. In PE animal model conducted by chronic administration of L-NAME, our aim was to detect the presence of neurological damage on cerebral tissues on E18 and hemodynamic changes measuring Doppler waveforms from fetal vessels. Wistar pregnant rats (n = 12) were assigned to receive 50 mg/Kg/day of L-NAME (PE group) versus control. Fetal Doppler scans were performed with a 13 MHz linear array transducer (VIVID 13 MHz probe GE Medical Systems). Pulsatility index (PI) from middle cerebral artery (MCA) were performed. After ultrasound exams animals were slaughter and fetal brains (n = 9) on E18 were extracted. Serial slices of central nervous system were obtained to analyse cleaved caspase 3 activity and number of apoptotic cells in 5 areas from central nervous system (CNS). In PE group, a significant changes in fetal PI of MCA was detected and an increase of apoptotic cells in fetal brain from E18 in subventricular and pallidum zones. Results showed direct brain damage to cerebral tissues exposed antenatally to experimental preeclamptic conditions and correlation with hemodynamics changes in fetal cerebral vessels. These findings were independents factors as prematurity or intrapartum hypoxia. More studies will be necessary to dilucidate brain damage mechanisms in this model." @default.
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- W1986840981 date "2010-10-01" @default.
- W1986840981 modified "2023-10-16" @default.
- W1986840981 title "OP15.08: Intrauterine fetal brain damage in preeclamptic animal model: hemodynamic and histologic changes" @default.
- W1986840981 doi "https://doi.org/10.1002/uog.8065" @default.
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