FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986852088> ?p ?o ?g. }

• W1986852088 endingPage "73" @default.
• W1986852088 startingPage "73" @default.
• W1986852088 abstract "Significant progress has been made in understanding pharmacokinetics (PK), pharmacodynamics (PD), as well as toxicity profiles of therapeutic proteins in animals and humans, which have been in commercial development for more than three decades. However, in the PK arena, many fundamental questions remain to be resolved. Investigative and bioanalytical tools need to be established to improve the translation of PK data from animals to humans, and from in vitro assays to in vivo readouts, which would ultimately lead to a higher success rate in drug development. In toxicology, it is known, in general, what studies are needed to safely develop therapeutic proteins, and what studies do not provide relevant information. One of the major complicating factors in nonclinical and clinical programs for therapeutic proteins is the impact of immunogenicity. In this review, we will highlight the emerging science and technology, as well as the challenges around the pharmacokinetic- and safety-related issues in drug development of mAbs and other therapeutic proteins." @default.
• W1986852088 created "2016-06-24" @default.
• W1986852088 creator A5009031195 @default.
• W1986852088 creator A5021299258 @default.
• W1986852088 creator A5039211143 @default.
• W1986852088 creator A5042055893 @default.
• W1986852088 creator A5091773218 @default.
• W1986852088 date "2012-01-01" @default.
• W1986852088 modified "2023-10-16" @default.
• W1986852088 title "Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges" @default.
• W1986852088 cites W101392706 @default.
• W1986852088 cites W123688951 @default.
• W1986852088 cites W141886111 @default.
• W1986852088 cites W1424849964 @default.
• W1986852088 cites W1484092314 @default.
• W1986852088 cites W1490736032 @default.
• W1986852088 cites W1525904369 @default.
• W1986852088 cites W1540899451 @default.
• W1986852088 cites W1547437295 @default.
• W1986852088 cites W1561925924 @default.
• W1986852088 cites W1569589672 @default.
• W1986852088 cites W1586699825 @default.
• W1986852088 cites W1595328377 @default.
• W1986852088 cites W1705666194 @default.
• W1986852088 cites W1775429285 @default.
• W1986852088 cites W194230369 @default.
• W1986852088 cites W1944996883 @default.
• W1986852088 cites W1963527734 @default.
• W1986852088 cites W1967265624 @default.
• W1986852088 cites W1968030422 @default.
• W1986852088 cites W1970875728 @default.
• W1986852088 cites W1971242419 @default.
• W1986852088 cites W1972624827 @default.
• W1986852088 cites W1975876675 @default.
• W1986852088 cites W1977098962 @default.
• W1986852088 cites W1979162895 @default.
• W1986852088 cites W1979742080 @default.
• W1986852088 cites W1980495778 @default.
• W1986852088 cites W1983541189 @default.
• W1986852088 cites W1984967510 @default.
• W1986852088 cites W1985705893 @default.
• W1986852088 cites W1986163443 @default.
• W1986852088 cites W1987739433 @default.
• W1986852088 cites W1988105075 @default.
• W1986852088 cites W1993986769 @default.
• W1986852088 cites W1995791421 @default.
• W1986852088 cites W1996045402 @default.
• W1986852088 cites W1996985574 @default.
• W1986852088 cites W1998726531 @default.
• W1986852088 cites W1999464347 @default.
• W1986852088 cites W2002765161 @default.
• W1986852088 cites W2007340026 @default.
• W1986852088 cites W2014075805 @default.
• W1986852088 cites W2016102616 @default.
• W1986852088 cites W2021239485 @default.
• W1986852088 cites W2027014013 @default.
• W1986852088 cites W2027894892 @default.
• W1986852088 cites W2032709270 @default.
• W1986852088 cites W2034421123 @default.
• W1986852088 cites W2035742026 @default.
• W1986852088 cites W2036601374 @default.
• W1986852088 cites W2037201482 @default.
• W1986852088 cites W2037248548 @default.
• W1986852088 cites W2037680981 @default.
• W1986852088 cites W2039144093 @default.
• W1986852088 cites W2043840173 @default.
• W1986852088 cites W2044204671 @default.
• W1986852088 cites W2044617562 @default.
• W1986852088 cites W2044703421 @default.
• W1986852088 cites W2044851147 @default.
• W1986852088 cites W2047000833 @default.
• W1986852088 cites W2047468814 @default.
• W1986852088 cites W2050869931 @default.
• W1986852088 cites W2052491267 @default.
• W1986852088 cites W2052789788 @default.
• W1986852088 cites W2052810996 @default.
• W1986852088 cites W2054363200 @default.
• W1986852088 cites W2054739927 @default.
• W1986852088 cites W2054898031 @default.
• W1986852088 cites W2054939724 @default.
• W1986852088 cites W2059050919 @default.
• W1986852088 cites W2061641422 @default.
• W1986852088 cites W2066751846 @default.
• W1986852088 cites W2068850463 @default.
• W1986852088 cites W2072958011 @default.
• W1986852088 cites W2075678951 @default.
• W1986852088 cites W2076171495 @default.
• W1986852088 cites W2076709027 @default.
• W1986852088 cites W2077025291 @default.
• W1986852088 cites W2077594738 @default.
• W1986852088 cites W2078317394 @default.
• W1986852088 cites W2080199877 @default.
• W1986852088 cites W2080611602 @default.
• W1986852088 cites W2080876607 @default.
• W1986852088 cites W2081943656 @default.
• W1986852088 cites W2083768174 @default.
• W1986852088 cites W2084136419 @default.
• W1986852088 cites W2093320115 @default.

• next