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• W1986892009 abstract "Glycine-extended gastrin precursors (G-Gly) were considered as processing intermediates devoid of biological activity. However, we have recently identified selective receptors for G-Gly which mediate the proliferative effects of this precursor. Little is known about the signaling pathways activated by G-Gly. In the present study, we demonstrate that PI-3-kinase is rapidly and transiently activated by G-Gly. We also observed a rapid increase in the tyrosine phosphorylation of IRS-1 and an activation of the PI-3-kinase in anti-IRS-1 immunoprecipitates, suggesting that PI-3-kinase may be activated by association with tyrosine phosphorylated IRS-1. We also demonstrated that gastrin precursors activate the serine/threonine kinase, p70 kDa S6 kinase (p70S6K), through a wortmannin sensitive pathway." @default.
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• W1986892009 date "1997-07-01" @default.
• W1986892009 modified "2023-09-25" @default.
• W1986892009 title "Tyrosine Phosphorylation of Insulin Receptor Substrate-1 and Activation of the PI-3-Kinase Pathway by Glycine-Extended Gastrin Precursors" @default.
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• W1986892009 doi "https://doi.org/10.1006/bbrc.1997.6975" @default.
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