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• W1986909496 endingPage "691" @default.
• W1986909496 startingPage "686" @default.
• W1986909496 abstract "The physicochemical characteristics and oral absorption of a poorly water-soluble drug, K-832, adsorbed onto porous silica (Sylysia 350), were compared with those of K-832 adsorbed onto non-porous silica (Aerosil 200). K-832 and silica were treated with supercritical CO(2) (scCO(2)) to produce K-832-Sylysia 350 and K-832-Aerosil 200 formulations. Scanning electron microscopy, polarizing microscopy, powder X-ray diffraction, and differential scanning calorimetry results suggested that K-832 mainly existed in an amorphous state in both formulations. The specific surface area of both formulations was much larger than that of pure K-832 crystals. The dissolution rate of K-832 from both formulations was considerably greater than that from corresponding physical mixtures due to rapid wetting of the hydrophilic carrier surfaces and amorphous state, the dissolution from the K-832-Sylysia 350 formulation being the fastest. In vivo absorption tests on the two formulations indicated no significant differences in their peak concentration (C(max)) and the area under their plasma concentration-time curve (AUC), while the concentrations of K-832 in the K-832-Sylysia 350 formulation were significantly higher than those in the K-832-Aerosil 200 formulation 1 h and 1.5 h after administration of these formulations (p<0.05). This could be attributed to the different dispersion states of K-832 in the formulations due to their different three-dimensional structures (porous and non-porous). In physical stability tests, the amorphous drugs in both formulations were stable at room temperature for at least 14 months. Thus, the absorption of poorly water-soluble drugs could be greatly improved by adsorption onto porous silica using scCO(2)." @default.
• W1986909496 created "2016-06-24" @default.
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• W1986909496 date "2011-01-01" @default.
• W1986909496 modified "2023-10-05" @default.
• W1986909496 title "Influence of Particle Design on Oral Absorption of Poorly Water-Soluble Drug in a Silica Particle-Supercritical Fluid System" @default.
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• W1986909496 doi "https://doi.org/10.1248/cpb.59.686" @default.
• W1986909496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21628901" @default.
• W1986909496 hasPublicationYear "2011" @default.
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