FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986914929> ?p ?o ?g. }

• W1986914929 endingPage "282" @default.
• W1986914929 startingPage "269" @default.
• W1986914929 abstract "MRL-lpr/lpr (lpr) mice develop profound lymphadenopathy resulting from the accumulation of CD4-CD8- (double-negative, DN) cells in the peripheral lymphoid organs. Earlier studies from our laboratory demonstrated an increased proportion of DN cells in the thymus of lpr mice with age. Inasmuch as the DN thymocytes constitute a heterogenous population of cells, in the present study, we investigated the TCR phenotype of DN thymocytes and their responsiveness to activation through the TCR. The DN thymocytes of young (1 month of age) lpr mice contained approximately 65% CD3+ cells of which approximately 60% were alpha beta-TCR+ and approximately 39% were gamma delta-TCR+ as detected by using pan anti-TCR mAbs. In old (4-6 months of age) or young MRL-(+/+) mice, similar proportions of CD3+, alpha beta- or gamma delta-TCR+ DN thymocytes were detected. Interestingly, however, in old (4-6 months of age) lpr mice, the CD3+ T cells increased to approximately 86% and the majority of these (approximately 81%) were alpha beta-TCR+ and only approximately 3% were gamma delta-TCR+. Also, in old lpr mice, there was a 10-fold increase in the absolute number of alpha beta-TCR+ DN cells in the thymus, whereas, the absolute number of gamma delta-TCR+ DN cells in the thymus did not alter significantly. Furthermore, a majority (approximately 84%) of the old lpr DN thymocytes expressed CD45R, similar to the peripheral DN T cells. In contrast, only a small number (approximately 1%) of DN thymocytes from young lpr or MRL-(+/+) mice expressed CD45R. The DN thymocytes from young lpr or MRL-(+/+) mice demonstrated strong and similar proliferative responsiveness to stimulation with PMA + calcium ionophore or PMA + IL-2, or to immobilized mAb directed against the TCRs (CD3, alpha beta and gamma delta). In contrast, the DN thymocytes and the DN peripheral T cells from old lpr mice demonstrated marked defect in responding to the above stimuli. The present study suggests that with the onset of lymphadenopathy, the DN cells in the thymus of old lpr mice are increasingly skewed toward the alpha beta-TCR repertoire, the majority of which express CD45R and respond poorly to mitogenic stimuli or when activated through the TCR. It is suggested that migration of such cells continuously to the periphery may result in severe lymphadenopathy seen in old MRL-lpr/lpr mice." @default.
• W1986914929 created "2016-06-24" @default.
• W1986914929 creator A5028331971 @default.
• W1986914929 creator A5046315471 @default.
• W1986914929 creator A5061239650 @default.
• W1986914929 creator A5071646389 @default.
• W1986914929 date "1991-10-01" @default.
• W1986914929 modified "2023-09-26" @default.
• W1986914929 title "CD4− CD8− thymocytes from MRL-lpr/lpr mice exhibit abnormal proportions of αβ- and γδ-TCR+ cells and demonstrate defective responsiveness when activated through the TCR" @default.
• W1986914929 cites W1599176230 @default.
• W1986914929 cites W1934463538 @default.
• W1986914929 cites W1975881258 @default.
• W1986914929 cites W1999952681 @default.
• W1986914929 cites W2026108503 @default.
• W1986914929 cites W2057940468 @default.
• W1986914929 cites W2060127523 @default.
• W1986914929 cites W2062497125 @default.
• W1986914929 cites W2142269895 @default.
• W1986914929 doi "https://doi.org/10.1016/0008-8749(91)90078-p" @default.
• W1986914929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1832583" @default.
• W1986914929 hasPublicationYear "1991" @default.
• W1986914929 type Work @default.
• W1986914929 sameAs 1986914929 @default.
• W1986914929 citedByCount "7" @default.
• W1986914929 countsByYear W19869149292019 @default.
• W1986914929 countsByYear W19869149292021 @default.
• W1986914929 crossrefType "journal-article" @default.
• W1986914929 hasAuthorship W1986914929A5028331971 @default.
• W1986914929 hasAuthorship W1986914929A5046315471 @default.
• W1986914929 hasAuthorship W1986914929A5061239650 @default.
• W1986914929 hasAuthorship W1986914929A5071646389 @default.
• W1986914929 hasConcept C114684123 @default.
• W1986914929 hasConcept C126322002 @default.
• W1986914929 hasConcept C134018914 @default.
• W1986914929 hasConcept C147483822 @default.
• W1986914929 hasConcept C153911025 @default.
• W1986914929 hasConcept C167672396 @default.
• W1986914929 hasConcept C19317047 @default.
• W1986914929 hasConcept C199360897 @default.
• W1986914929 hasConcept C203014093 @default.
• W1986914929 hasConcept C2776090121 @default.
• W1986914929 hasConcept C2776174256 @default.
• W1986914929 hasConcept C2778954852 @default.
• W1986914929 hasConcept C2908647359 @default.
• W1986914929 hasConcept C2992881475 @default.
• W1986914929 hasConcept C41008148 @default.
• W1986914929 hasConcept C71924100 @default.
• W1986914929 hasConcept C86803240 @default.
• W1986914929 hasConcept C8891405 @default.
• W1986914929 hasConcept C91394840 @default.
• W1986914929 hasConcept C99454951 @default.
• W1986914929 hasConceptScore W1986914929C114684123 @default.
• W1986914929 hasConceptScore W1986914929C126322002 @default.
• W1986914929 hasConceptScore W1986914929C134018914 @default.
• W1986914929 hasConceptScore W1986914929C147483822 @default.
• W1986914929 hasConceptScore W1986914929C153911025 @default.
• W1986914929 hasConceptScore W1986914929C167672396 @default.
• W1986914929 hasConceptScore W1986914929C19317047 @default.
• W1986914929 hasConceptScore W1986914929C199360897 @default.
• W1986914929 hasConceptScore W1986914929C203014093 @default.
• W1986914929 hasConceptScore W1986914929C2776090121 @default.
• W1986914929 hasConceptScore W1986914929C2776174256 @default.
• W1986914929 hasConceptScore W1986914929C2778954852 @default.
• W1986914929 hasConceptScore W1986914929C2908647359 @default.
• W1986914929 hasConceptScore W1986914929C2992881475 @default.
• W1986914929 hasConceptScore W1986914929C41008148 @default.
• W1986914929 hasConceptScore W1986914929C71924100 @default.
• W1986914929 hasConceptScore W1986914929C86803240 @default.
• W1986914929 hasConceptScore W1986914929C8891405 @default.
• W1986914929 hasConceptScore W1986914929C91394840 @default.
• W1986914929 hasConceptScore W1986914929C99454951 @default.
• W1986914929 hasIssue "2" @default.
• W1986914929 hasLocation W19869149291 @default.
• W1986914929 hasLocation W19869149292 @default.
• W1986914929 hasOpenAccess W1986914929 @default.
• W1986914929 hasPrimaryLocation W19869149291 @default.
• W1986914929 hasRelatedWork W1544488631 @default.
• W1986914929 hasRelatedWork W1591694811 @default.
• W1986914929 hasRelatedWork W1971801318 @default.
• W1986914929 hasRelatedWork W1986914929 @default.
• W1986914929 hasRelatedWork W2018076377 @default.
• W1986914929 hasRelatedWork W2067087802 @default.
• W1986914929 hasRelatedWork W2093020311 @default.
• W1986914929 hasRelatedWork W2100497713 @default.
• W1986914929 hasRelatedWork W2135503300 @default.
• W1986914929 hasRelatedWork W2326623647 @default.
• W1986914929 hasVolume "137" @default.
• W1986914929 isParatext "false" @default.
• W1986914929 isRetracted "false" @default.
• W1986914929 magId "1986914929" @default.
• W1986914929 workType "article" @default.