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- W1986921171 abstract "The AMPK pathway is a metabolic stress-related and energy censor pathway which plays important regulatory roles in normal and malignant cells. This cellular cascade controls generation of signals for initiation of mRNA translation via the mTOR pathway and exhibits regulatory roles on the initiation of autophagy. AMPK activators have been shown to suppress mTOR activity and to negatively control malignant transformation and cell proliferation of diverse malignant cell types. Such properties of AMPK inducers have generated substantial interest for the use of AMPK targeting compounds as antineoplastic agents and have provoked extensive research efforts to better define and classify the mechanisms controlling AMPK activity and its functional consequences in malignant cells." @default.
- W1986921171 created "2016-06-24" @default.
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- W1986921171 date "2012-01-05" @default.
- W1986921171 modified "2023-10-01" @default.
- W1986921171 title "Targeting AMPK in the treatment of malignancies" @default.
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- W1986921171 doi "https://doi.org/10.1002/jcb.23369" @default.
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