FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986941101> ?p ?o ?g. }

• W1986941101 endingPage "90" @default.
• W1986941101 startingPage "84" @default.
• W1986941101 abstract "The purpose of the present study was to prepare matrix extended release pellets of diclofenac potassium using low amount of release-modifying agents and, to compare its performance in vivo with coated pellets and matrix tablets. Coated pellets were prepared by extrusion–spheronization, followed by double layer coating using different polymers separately. Matrix pellets with different release rate in vitro were prepared by extrusion–spheronization with different kinds of retarding materials. Bioavailability study of different coated pellets revealed that the drug concentration in plasma of beagle dogs was too low to be detected and, implied that the drug was nearly not released from the preparations before reaching colon due to the appearance of lag time in the dissolution process. The phenomenon indicated that slow-release pellets of diclofenac potassium perhaps should not be developed as double membrane-controlled type. The AUC(0→24) of the immediate release pellets, the two matrix pellets and the reference were 304.4, 87.7, 204.1 and 179.1 μg h/ml, respectively. The Cmax of the formulations mentioned above were 46.3, 13.0, 33.6 and 32.1 μg/ml, respectively. All the matrix formulations, including the reference, exhibited incomplete absorption due to the short small intestine transit time and termination of the drug release in the colon because of its limited solubility. The matrix pellets were bioequivalent with the commercially available tablet (Voltaren®) although the drug release in vitro of the former was much faster, while the bioavailability of the matrix pellets with similar in vitro drug release to the reference (Voltaren®) was much lower than the latter. The results perhaps was caused by lacking of physical robustness in the waxy tablet formulation, resulted in low wet strength and easily destroyed by the mechanical destructive forces and finally introduced faster drug release rate in vivo. It is apparent that preparations with similar performance in vitro may differ a lot in vivo because of the differences in drug release rate in vivo owing to various wet strengths of excipients contained, especially for sustained release products." @default.
• W1986941101 created "2016-06-24" @default.
• W1986941101 creator A5002333612 @default.
• W1986941101 creator A5010022627 @default.
• W1986941101 creator A5012773578 @default.
• W1986941101 creator A5030345640 @default.
• W1986941101 creator A5065650359 @default.
• W1986941101 creator A5078424512 @default.
• W1986941101 creator A5078837753 @default.
• W1986941101 creator A5087099599 @default.
• W1986941101 date "2011-03-15" @default.
• W1986941101 modified "2023-10-07" @default.
• W1986941101 title "Preparation and in vitro–in vivo evaluation of double layer coated and matrix sustained release pellet formulations of diclofenac potassium" @default.
• W1986941101 cites W147545842 @default.
• W1986941101 cites W1579212850 @default.
• W1986941101 cites W15818305 @default.
• W1986941101 cites W1601948010 @default.
• W1986941101 cites W1606309567 @default.
• W1986941101 cites W1971181330 @default.
• W1986941101 cites W1974558951 @default.
• W1986941101 cites W1975911846 @default.
• W1986941101 cites W1982157333 @default.
• W1986941101 cites W1984353511 @default.
• W1986941101 cites W1999427660 @default.
• W1986941101 cites W2005918565 @default.
• W1986941101 cites W2008993336 @default.
• W1986941101 cites W2012411521 @default.
• W1986941101 cites W2018220913 @default.
• W1986941101 cites W2022500225 @default.
• W1986941101 cites W2028503323 @default.
• W1986941101 cites W2028890849 @default.
• W1986941101 cites W2029147126 @default.
• W1986941101 cites W2036971158 @default.
• W1986941101 cites W2040709342 @default.
• W1986941101 cites W2041260816 @default.
• W1986941101 cites W2048941247 @default.
• W1986941101 cites W2051749006 @default.
• W1986941101 cites W2055400975 @default.
• W1986941101 cites W2056158955 @default.
• W1986941101 cites W2057812714 @default.
• W1986941101 cites W2066795446 @default.
• W1986941101 cites W2069097315 @default.
• W1986941101 cites W2073177056 @default.
• W1986941101 cites W2080456908 @default.
• W1986941101 cites W2085444179 @default.
• W1986941101 cites W2086242565 @default.
• W1986941101 cites W2092784744 @default.
• W1986941101 cites W2113645620 @default.
• W1986941101 cites W2136427073 @default.
• W1986941101 cites W2149281204 @default.
• W1986941101 cites W2167882777 @default.
• W1986941101 cites W2400170788 @default.
• W1986941101 cites W2412723059 @default.
• W1986941101 cites W2413882985 @default.
• W1986941101 cites W2468552583 @default.
• W1986941101 cites W562943612 @default.
• W1986941101 cites W601328296 @default.
• W1986941101 cites W69985727 @default.
• W1986941101 cites W75387778 @default.
• W1986941101 cites W83759074 @default.
• W1986941101 doi "https://doi.org/10.1016/j.ijpharm.2010.12.043" @default.
• W1986941101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21219996" @default.
• W1986941101 hasPublicationYear "2011" @default.
• W1986941101 type Work @default.
• W1986941101 sameAs 1986941101 @default.
• W1986941101 citedByCount "23" @default.
• W1986941101 countsByYear W19869411012012 @default.
• W1986941101 countsByYear W19869411012013 @default.
• W1986941101 countsByYear W19869411012014 @default.
• W1986941101 countsByYear W19869411012015 @default.
• W1986941101 countsByYear W19869411012016 @default.
• W1986941101 countsByYear W19869411012017 @default.
• W1986941101 countsByYear W19869411012019 @default.
• W1986941101 countsByYear W19869411012020 @default.
• W1986941101 countsByYear W19869411012022 @default.
• W1986941101 crossrefType "journal-article" @default.
• W1986941101 hasAuthorship W1986941101A5002333612 @default.
• W1986941101 hasAuthorship W1986941101A5010022627 @default.
• W1986941101 hasAuthorship W1986941101A5012773578 @default.
• W1986941101 hasAuthorship W1986941101A5030345640 @default.
• W1986941101 hasAuthorship W1986941101A5065650359 @default.
• W1986941101 hasAuthorship W1986941101A5078424512 @default.
• W1986941101 hasAuthorship W1986941101A5078837753 @default.
• W1986941101 hasAuthorship W1986941101A5087099599 @default.
• W1986941101 hasConcept C106487976 @default.
• W1986941101 hasConcept C159985019 @default.
• W1986941101 hasConcept C181389837 @default.
• W1986941101 hasConcept C185592680 @default.
• W1986941101 hasConcept C192562407 @default.
• W1986941101 hasConcept C22979827 @default.
• W1986941101 hasConcept C2778958987 @default.
• W1986941101 hasConcept C2779826273 @default.
• W1986941101 hasConcept C2780584874 @default.
• W1986941101 hasConcept C43617362 @default.
• W1986941101 hasConcept C55493867 @default.
• W1986941101 hasConcept C71924100 @default.
• W1986941101 hasConcept C77281830 @default.
• W1986941101 hasConcept C98274493 @default.

• next