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- W1986941314 abstract "α-Latrotoxin (α-LTx), a vertebrate neurotoxin isolated from Black Widow Spider venom, causes massive spontaneous neurotransmitter release. The molecular mechanism(s) by which the toxin exerts its effect is largely unknown. Here we report identification and purification of a novel membrane receptor with high affinity for α-LTx. Unlike neurexin Ia, a previously described high affinity α-LTx receptor, this novel protein binds α-LTx independently of Ca2+presence and therefore may be a mediator of the calcium-independent stimulation of neurotransmitter release by α-latrotoxin. The major protein component of calcium-independent α-LTx receptors is a novel Mr 120,000 protein which does not belong to the neurexin family. Among several tissues tested, the Mr 120,000 protein was found only in brain." @default.
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- W1986941314 date "1996-10-01" @default.
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- W1986941314 title "The Calcium-Independent Receptor of α-Latrotoxin Is Not a Neurexin" @default.
- W1986941314 doi "https://doi.org/10.1006/bbrc.1996.1598" @default.
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