FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986948471> ?p ?o ?g. }

• W1986948471 abstract "Pentoxifylline, a methylxanthine derivative with significant hemorheologic properties, is used for claudication in patients with peripheral vascular disease, and experimentally for ischemic injury to organs because of its antioxidant and antiinflammatory effects. We used a rat model of severe small intestinal ischemia and reperfusion to determine the ability of pentoxifylline in improving survival, molecular response, and pathological protection.We used 6 groups of male Wistar rats (n=25 each). The superior mesenteric artery was occluded for 120 minutes. Laboratory and tissue studies were done on 5 animals, 1 hour after reperfusion, and animal survival was assessed at 7 days. There were 2 control groups that received normal saline, either before ischemia or during reperfusion. The 4 treated groups received pentoxifylline 1 or 10 mg/kg at the same times mentioned above. Laboratory studies included measuring serum lactic acid dehydrogenase, tumor necrosis factor-α, interleukin-1β, and interleukin-6.Intestinal tissue malondialdehyde and myeloperoxidase in small intestine tissue also were measured. Histology and laser vascular blood flow at baseline and reperfusion were obtained, and survival was determined 7 days after ischemia.A significant survival benefit in the animals treated with 10 mg/kg of pentoxifylline at reperfusion was noted. This coincided with a reduction in biochemical markers of cell damage - specifically, serum lactic acid dehydrogenase, and tissue malondialdehyde, ischemia, and reperfusion. Additionally, we saw decreased levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6. Improved postreperfusion blood flow shown by laser Doppler technology also was seen in the treated groups. Histologically, we observed less neutrophil infiltration in the intestine of ischemic-treated rats. Also seen in the control animals were increased necrotic lesions in the microvilli with a higher presence of lysozyme in the Paneth cells. Survival was significantly better at 7 days (70% vs 40%) when we compared the pentoxifylline group treated at reperfusion (10 mg/kg) to the ischemic controls.Pentoxifylline had a significant protective effect on severely ischemic bowel when administered during reperfusion at a dosage of 10 mg/kg. Better survival, improved histology, and molecular response should urge consideration of the consideration of applying these findings in some general surgery and transplant conditions." @default.
• W1986948471 created "2016-06-24" @default.
• W1986948471 creator A5034463921 @default.
• W1986948471 creator A5054503540 @default.
• W1986948471 creator A5060438096 @default.
• W1986948471 creator A5076442045 @default.
• W1986948471 creator A5078613488 @default.
• W1986948471 date "2013-06-17" @default.
• W1986948471 modified "2023-09-25" @default.
• W1986948471 title "Pentoxifylline Protects the Small Intestine After Severe Ischemia and Reperfusion" @default.
• W1986948471 cites W14605830 @default.
• W1986948471 cites W1545917122 @default.
• W1986948471 cites W1775749144 @default.
• W1986948471 cites W1817951592 @default.
• W1986948471 cites W1978173836 @default.
• W1986948471 cites W1983310681 @default.
• W1986948471 cites W1996274490 @default.
• W1986948471 cites W2005340562 @default.
• W1986948471 cites W2008060350 @default.
• W1986948471 cites W2026648244 @default.
• W1986948471 cites W2038254164 @default.
• W1986948471 cites W2041807315 @default.
• W1986948471 cites W2046778943 @default.
• W1986948471 cites W2054860783 @default.
• W1986948471 cites W2055026648 @default.
• W1986948471 cites W2056267908 @default.
• W1986948471 cites W2063576791 @default.
• W1986948471 cites W2063623949 @default.
• W1986948471 cites W2063850946 @default.
• W1986948471 cites W2063884517 @default.
• W1986948471 cites W2065452704 @default.
• W1986948471 cites W2065599707 @default.
• W1986948471 cites W2069655299 @default.
• W1986948471 cites W2072659568 @default.
• W1986948471 cites W2090291392 @default.
• W1986948471 cites W2092045246 @default.
• W1986948471 cites W2092737965 @default.
• W1986948471 cites W2105230881 @default.
• W1986948471 cites W2108437825 @default.
• W1986948471 cites W2142702612 @default.
• W1986948471 cites W2146643754 @default.
• W1986948471 cites W2153267965 @default.
• W1986948471 cites W2165780526 @default.
• W1986948471 cites W2240611838 @default.
• W1986948471 cites W2314295465 @default.
• W1986948471 cites W2321604334 @default.
• W1986948471 cites W2398885723 @default.
• W1986948471 cites W2399124798 @default.
• W1986948471 cites W2403519451 @default.
• W1986948471 cites W2409103450 @default.
• W1986948471 cites W2409936408 @default.
• W1986948471 cites W2417417741 @default.
• W1986948471 cites W2419213160 @default.
• W1986948471 cites W2435309314 @default.
• W1986948471 cites W53266457 @default.
• W1986948471 doi "https://doi.org/10.6002/ect.2012.0222" @default.
• W1986948471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23767943" @default.
• W1986948471 hasPublicationYear "2013" @default.
• W1986948471 type Work @default.
• W1986948471 sameAs 1986948471 @default.
• W1986948471 citedByCount "15" @default.
• W1986948471 countsByYear W19869484712014 @default.
• W1986948471 countsByYear W19869484712015 @default.
• W1986948471 countsByYear W19869484712016 @default.
• W1986948471 countsByYear W19869484712017 @default.
• W1986948471 countsByYear W19869484712018 @default.
• W1986948471 crossrefType "journal-article" @default.
• W1986948471 hasAuthorship W1986948471A5034463921 @default.
• W1986948471 hasAuthorship W1986948471A5054503540 @default.
• W1986948471 hasAuthorship W1986948471A5060438096 @default.
• W1986948471 hasAuthorship W1986948471A5076442045 @default.
• W1986948471 hasAuthorship W1986948471A5078613488 @default.
• W1986948471 hasConcept C126322002 @default.
• W1986948471 hasConcept C142724271 @default.
• W1986948471 hasConcept C181199279 @default.
• W1986948471 hasConcept C2776151105 @default.
• W1986948471 hasConcept C2777318727 @default.
• W1986948471 hasConcept C2777397205 @default.
• W1986948471 hasConcept C2778401633 @default.
• W1986948471 hasConcept C2780114680 @default.
• W1986948471 hasConcept C2780404050 @default.
• W1986948471 hasConcept C42219234 @default.
• W1986948471 hasConcept C503630168 @default.
• W1986948471 hasConcept C541997718 @default.
• W1986948471 hasConcept C55493867 @default.
• W1986948471 hasConcept C71924100 @default.
• W1986948471 hasConcept C86803240 @default.
• W1986948471 hasConcept C90924648 @default.
• W1986948471 hasConceptScore W1986948471C126322002 @default.
• W1986948471 hasConceptScore W1986948471C142724271 @default.
• W1986948471 hasConceptScore W1986948471C181199279 @default.
• W1986948471 hasConceptScore W1986948471C2776151105 @default.
• W1986948471 hasConceptScore W1986948471C2777318727 @default.
• W1986948471 hasConceptScore W1986948471C2777397205 @default.
• W1986948471 hasConceptScore W1986948471C2778401633 @default.
• W1986948471 hasConceptScore W1986948471C2780114680 @default.
• W1986948471 hasConceptScore W1986948471C2780404050 @default.
• W1986948471 hasConceptScore W1986948471C42219234 @default.
• W1986948471 hasConceptScore W1986948471C503630168 @default.
• W1986948471 hasConceptScore W1986948471C541997718 @default.

• next