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- W1986963337 startingPage "752" @default.
- W1986963337 abstract "Immune cells, such as cytotoxic T lymphocytes, natural killer cells, B cells, and dendritic cells, have a central role in cancer immunotherapy. Conventional studies of cancer immunotherapy have focused mainly on the search for an efficient means to prime/activate tumor-associated antigen-specific immunity. A systematic understanding of the molecular basis of the trafficking and biodistribution of immune cells, however, is important for the development of more efficacious cancer immunotherapies. It is well established that the basis and premise of immunotherapy is the accumulation of effective immune cells in tumor tissues. Therefore, it is crucial to control the distribution of immune cells to optimize cancer immunotherapy. Recent characterization of various chemokines and chemokine receptors in the immune system has increased our knowledge of the regulatory mechanisms of the immune response and tolerance based on immune cell localization. Here, we review the immune cell recruitment and cell-based systems that can potentially control the systemic pharmacokinetics of immune cells and, in particular, focus on cell migrating molecules, i.e., chemokines, and their receptors, and their use in cancer immunotherapy." @default.
- W1986963337 created "2016-06-24" @default.
- W1986963337 creator A5056435839 @default.
- W1986963337 creator A5063867301 @default.
- W1986963337 creator A5069468154 @default.
- W1986963337 creator A5072978499 @default.
- W1986963337 date "2007-09-22" @default.
- W1986963337 modified "2023-09-29" @default.
- W1986963337 title "Immune Cell Recruitment and Cell-Based System for Cancer Therapy" @default.
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