FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986969470> ?p ?o ?g. }

• W1986969470 endingPage "3970" @default.
• W1986969470 startingPage "3963" @default.
• W1986969470 abstract "Persistent organic pollutants (POPs) are a group of organic or chemicals that adversely affect human health and are persistent in the environment. These highly toxic compounds include industrial chemicals, pesticides such as organochlorines, and unwanted wastes such as dioxins. Although studies have described the general toxicity effects of organochlorine pesticides, the mechanisms underlying its potential carcinogenic effects in the liver are not well understood. In this study, we analyzed the effect of three organochlorine pesticides (dichlorodiphenyltrichloroethane, heptachlore and endosulfan) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the epithelial to mesenchymal transition (EMT) in primary cultured human hepatocytes. We found that these compounds modified the hepatocyte phenotype, inducing cell spread, formation of lamellipodia structures and reorganization of the actin cytoskeleton in stress fibers. These morphological alterations were accompanied by disruption of cell-cell junctions, E-cadherin repression and albumin down-regulation. Interestingly, these characteristic features of dedifferentiating hepatocytes were correlated with the gain of expression of various mesenchymal genes, including vimentin, fibronectin and its receptor ITGA5. These various results show that organochlorines and TCDD accelerate cultured human hepatocyte dedifferentiation and EMT processes. These events could account, at least in part, for the carcionogenic and/or fibrogenic activities of these POPs." @default.
• W1986969470 created "2016-06-24" @default.
• W1986969470 creator A5013463328 @default.
• W1986969470 creator A5028772179 @default.
• W1986969470 creator A5070408795 @default.
• W1986969470 creator A5077600677 @default.
• W1986969470 date "2012-11-01" @default.
• W1986969470 modified "2023-09-25" @default.
• W1986969470 title "Organochlorine pesticides induce epithelial to mesenchymal transition of human primary cultured hepatocytes" @default.
• W1986969470 cites W130546658 @default.
• W1986969470 cites W1674217635 @default.
• W1986969470 cites W1920794749 @default.
• W1986969470 cites W1980223650 @default.
• W1986969470 cites W1983072760 @default.
• W1986969470 cites W1985456778 @default.
• W1986969470 cites W1988944444 @default.
• W1986969470 cites W1994478382 @default.
• W1986969470 cites W2010985641 @default.
• W1986969470 cites W2012117640 @default.
• W1986969470 cites W2013506996 @default.
• W1986969470 cites W2014213991 @default.
• W1986969470 cites W2015879043 @default.
• W1986969470 cites W2018884883 @default.
• W1986969470 cites W2019175074 @default.
• W1986969470 cites W2028673146 @default.
• W1986969470 cites W2028919524 @default.
• W1986969470 cites W2033635252 @default.
• W1986969470 cites W2035617243 @default.
• W1986969470 cites W2036792438 @default.
• W1986969470 cites W2039298921 @default.
• W1986969470 cites W2039606117 @default.
• W1986969470 cites W2041940942 @default.
• W1986969470 cites W2047396583 @default.
• W1986969470 cites W2050750704 @default.
• W1986969470 cites W2051096454 @default.
• W1986969470 cites W2052231385 @default.
• W1986969470 cites W2062395451 @default.
• W1986969470 cites W2066947275 @default.
• W1986969470 cites W2071489477 @default.
• W1986969470 cites W2071609983 @default.
• W1986969470 cites W2072482644 @default.
• W1986969470 cites W2077511002 @default.
• W1986969470 cites W2079630625 @default.
• W1986969470 cites W2086541189 @default.
• W1986969470 cites W2093157637 @default.
• W1986969470 cites W2115715088 @default.
• W1986969470 cites W2123233663 @default.
• W1986969470 cites W2143578762 @default.
• W1986969470 cites W2154589460 @default.
• W1986969470 cites W2155405391 @default.
• W1986969470 cites W2168085884 @default.
• W1986969470 cites W2280994160 @default.
• W1986969470 cites W2319159316 @default.
• W1986969470 cites W4232683529 @default.
• W1986969470 cites W4241668253 @default.
• W1986969470 cites W4255712601 @default.
• W1986969470 cites W6650985 @default.
• W1986969470 doi "https://doi.org/10.1016/j.fct.2012.08.009" @default.
• W1986969470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22902829" @default.
• W1986969470 hasPublicationYear "2012" @default.
• W1986969470 type Work @default.
• W1986969470 sameAs 1986969470 @default.
• W1986969470 citedByCount "21" @default.
• W1986969470 countsByYear W19869694702013 @default.
• W1986969470 countsByYear W19869694702014 @default.
• W1986969470 countsByYear W19869694702015 @default.
• W1986969470 countsByYear W19869694702016 @default.
• W1986969470 countsByYear W19869694702017 @default.
• W1986969470 countsByYear W19869694702018 @default.
• W1986969470 countsByYear W19869694702019 @default.
• W1986969470 countsByYear W19869694702020 @default.
• W1986969470 countsByYear W19869694702021 @default.
• W1986969470 countsByYear W19869694702023 @default.
• W1986969470 crossrefType "journal-article" @default.
• W1986969470 hasAuthorship W1986969470A5013463328 @default.
• W1986969470 hasAuthorship W1986969470A5028772179 @default.
• W1986969470 hasAuthorship W1986969470A5070408795 @default.
• W1986969470 hasAuthorship W1986969470A5077600677 @default.
• W1986969470 hasConcept C104317684 @default.
• W1986969470 hasConcept C147447768 @default.
• W1986969470 hasConcept C1491633281 @default.
• W1986969470 hasConcept C161176658 @default.
• W1986969470 hasConcept C178790620 @default.
• W1986969470 hasConcept C185592680 @default.
• W1986969470 hasConcept C18903297 @default.
• W1986969470 hasConcept C194232998 @default.
• W1986969470 hasConcept C198826908 @default.
• W1986969470 hasConcept C202751555 @default.
• W1986969470 hasConcept C203014093 @default.
• W1986969470 hasConcept C204232928 @default.
• W1986969470 hasConcept C2776200302 @default.
• W1986969470 hasConcept C29730261 @default.
• W1986969470 hasConcept C55493867 @default.
• W1986969470 hasConcept C58207958 @default.
• W1986969470 hasConcept C76419328 @default.
• W1986969470 hasConcept C86492073 @default.
• W1986969470 hasConcept C86803240 @default.
• W1986969470 hasConcept C95444343 @default.

• next