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• W1986971598 abstract "In the latero-anterior hypothalamus (LAH) increased glutamate and vasopressin (AVP) activity facilitate anabolic androgenic steroid (AAS)-induced offensive aggression. In addition, adolescent AAS treatment increases the strength of glutamate-mediated connections between the LAH and the brain nucleus of stria terminalis (BNST). The current set of studies used male Syrian hamsters exposed to AAS during adolescence to examine whether increased glutamate-mediated stimulation of the BNST is dependent on LAH-AVP signaling and whether this neural pathway modulates adolescent AAS-induced offensive aggression. In the first set of AAS-treated animals offensive aggression was measured following blockade of glutamate activity within the BNST using NBQX. Then, in a second group of AAS-treated animals aggression levels were examined following simultaneous blockade of LAH-AVP activity using Manning compound and stimulation of BNST glutamate using AMPA. Lastly, the number of AVP fibers in apposition to glutamate cells was examined in AAS and control animals, using double-label immunofluorescence. The results showed that administration of NBQX into the BNST dose-dependently reduced aggressive behavior in AAS-treated animals. Further, the current results replicated previous findings showing that blockade of LAH-AVP significantly reduces aggressive behavior in AAS-treated animals. In these animals stimulation of BNST-AMPA receptors had a linear effect on aggression, where the smallest dose exacerbated the inhibitory effect of the V1a antagonist, the medium dose had no effect and the highest dose recuperated aggression to control levels. Finally when compared with control animals, AAS treatment produced a significant increase in the number of AVP fibers in apposition to LAH-glutamate cells. Overall, these results identify the BNST as a key brain region involved in aggression control and provide strong evidence suggesting that AVPergic-mediated stimulation of BNST-glutamate is a possible mechanism that facilitates aggression expression in adolescent AAS-treated animals." @default.
• W1986971598 created "2016-06-24" @default.
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• W1986971598 date "2011-06-01" @default.
• W1986971598 modified "2023-09-23" @default.
• W1986971598 title "Glutamate-vasopressin interactions and the neurobiology of anabolic steroid-induced offensive aggression" @default.
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• W1986971598 doi "https://doi.org/10.1016/j.neuroscience.2011.03.056" @default.
• W1986971598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21459130" @default.
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