FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986979630> ?p ?o ?g. }

• W1986979630 endingPage "1156" @default.
• W1986979630 startingPage "1149" @default.
• W1986979630 abstract "We observed changes of endothelin content and endothelin mRNA in vivo in vascular calcification and in vitro in calcification of vascular smooth muscle cells to explore the role of endothelin in vascular calcification. Calcification model in vivo was induced by administration of Vitamin D3 plus nicotine. Calcification of vascular smooth muscle cells (VSMCs) was induced by β-glycerophosphate. Endothelin content was measured by using radioimmunoassay. Endothelin mRNA amount was determined by using competitive quantitative RT-PCR. The results showed that calcium content, 45Ca2+ uptake and alkaline phosphatase (ALP) activity were increased in calcified VSMCs, compared with controls, but were decreased, compared with calcified VSMCs plus BQ123 group. The endothelin content in the medium and endothelin mRNA in VSMCs were elevated by 35 and 120% (P<0.05), respectively, compared with those normal VSMCs. Calcium content, 45Ca2+ accumulation and ALP activity in calcified arteries increased by 5.0-, 1.4-, and 1.4-fold. The endothelin levels in plasma and aorta as well as the amount of endothelin mRNA in calcified aorta were increased by 102, 103, and 22%, respectively, compared with control group. However, calcium content, 45Ca2+ uptake and ALP activity in VDN plus bosentan group was 33, 36.7, and 40.4% lower than those in VDN group. These results indicated an upregulated endothelin gene expression as well as an increased production of endothelin in calcified aorta and VSMCs with BQ123 and bosentan significantly reducing vascular calcification. This suggested that endothelin might be involved in pathogenesis of vascular calcification." @default.
• W1986979630 created "2016-06-24" @default.
• W1986979630 creator A5002919496 @default.
• W1986979630 creator A5042347863 @default.
• W1986979630 creator A5042748112 @default.
• W1986979630 creator A5046259476 @default.
• W1986979630 creator A5064733494 @default.
• W1986979630 creator A5073360242 @default.
• W1986979630 creator A5090178654 @default.
• W1986979630 date "2003-08-01" @default.
• W1986979630 modified "2023-10-11" @default.
• W1986979630 title "Endothelin-1 is a potent regulator in vivo in vascular calcification and in vitro in calcification of vascular smooth muscle cells" @default.
• W1986979630 cites W164399760 @default.
• W1986979630 cites W1970778194 @default.
• W1986979630 cites W1973653270 @default.
• W1986979630 cites W1975709087 @default.
• W1986979630 cites W1986695347 @default.
• W1986979630 cites W1994072695 @default.
• W1986979630 cites W2000748391 @default.
• W1986979630 cites W2005754762 @default.
• W1986979630 cites W2040654758 @default.
• W1986979630 cites W2063079389 @default.
• W1986979630 cites W2068883451 @default.
• W1986979630 cites W2081684149 @default.
• W1986979630 cites W2084979251 @default.
• W1986979630 cites W2086649274 @default.
• W1986979630 cites W2100503761 @default.
• W1986979630 cites W2113272897 @default.
• W1986979630 cites W2123225601 @default.
• W1986979630 cites W2127004701 @default.
• W1986979630 cites W2132367817 @default.
• W1986979630 cites W2313946183 @default.
• W1986979630 cites W4293247451 @default.
• W1986979630 doi "https://doi.org/10.1016/j.peptides.2003.07.008" @default.
• W1986979630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14612185" @default.
• W1986979630 hasPublicationYear "2003" @default.
• W1986979630 type Work @default.
• W1986979630 sameAs 1986979630 @default.
• W1986979630 citedByCount "52" @default.
• W1986979630 countsByYear W19869796302012 @default.
• W1986979630 countsByYear W19869796302013 @default.
• W1986979630 countsByYear W19869796302014 @default.
• W1986979630 countsByYear W19869796302015 @default.
• W1986979630 countsByYear W19869796302016 @default.
• W1986979630 countsByYear W19869796302017 @default.
• W1986979630 countsByYear W19869796302018 @default.
• W1986979630 countsByYear W19869796302019 @default.
• W1986979630 countsByYear W19869796302020 @default.
• W1986979630 countsByYear W19869796302021 @default.
• W1986979630 countsByYear W19869796302023 @default.
• W1986979630 crossrefType "journal-article" @default.
• W1986979630 hasAuthorship W1986979630A5002919496 @default.
• W1986979630 hasAuthorship W1986979630A5042347863 @default.
• W1986979630 hasAuthorship W1986979630A5042748112 @default.
• W1986979630 hasAuthorship W1986979630A5046259476 @default.
• W1986979630 hasAuthorship W1986979630A5064733494 @default.
• W1986979630 hasAuthorship W1986979630A5073360242 @default.
• W1986979630 hasAuthorship W1986979630A5090178654 @default.
• W1986979630 hasConcept C126322002 @default.
• W1986979630 hasConcept C134018914 @default.
• W1986979630 hasConcept C144980905 @default.
• W1986979630 hasConcept C149601957 @default.
• W1986979630 hasConcept C150903083 @default.
• W1986979630 hasConcept C160160445 @default.
• W1986979630 hasConcept C170493617 @default.
• W1986979630 hasConcept C181199279 @default.
• W1986979630 hasConcept C185592680 @default.
• W1986979630 hasConcept C207001950 @default.
• W1986979630 hasConcept C2779395532 @default.
• W1986979630 hasConcept C2779980429 @default.
• W1986979630 hasConcept C2780309369 @default.
• W1986979630 hasConcept C2781109936 @default.
• W1986979630 hasConcept C2992686903 @default.
• W1986979630 hasConcept C519063684 @default.
• W1986979630 hasConcept C55493867 @default.
• W1986979630 hasConcept C71924100 @default.
• W1986979630 hasConcept C86803240 @default.
• W1986979630 hasConceptScore W1986979630C126322002 @default.
• W1986979630 hasConceptScore W1986979630C134018914 @default.
• W1986979630 hasConceptScore W1986979630C144980905 @default.
• W1986979630 hasConceptScore W1986979630C149601957 @default.
• W1986979630 hasConceptScore W1986979630C150903083 @default.
• W1986979630 hasConceptScore W1986979630C160160445 @default.
• W1986979630 hasConceptScore W1986979630C170493617 @default.
• W1986979630 hasConceptScore W1986979630C181199279 @default.
• W1986979630 hasConceptScore W1986979630C185592680 @default.
• W1986979630 hasConceptScore W1986979630C207001950 @default.
• W1986979630 hasConceptScore W1986979630C2779395532 @default.
• W1986979630 hasConceptScore W1986979630C2779980429 @default.
• W1986979630 hasConceptScore W1986979630C2780309369 @default.
• W1986979630 hasConceptScore W1986979630C2781109936 @default.
• W1986979630 hasConceptScore W1986979630C2992686903 @default.
• W1986979630 hasConceptScore W1986979630C519063684 @default.
• W1986979630 hasConceptScore W1986979630C55493867 @default.
• W1986979630 hasConceptScore W1986979630C71924100 @default.
• W1986979630 hasConceptScore W1986979630C86803240 @default.
• W1986979630 hasIssue "8" @default.
• W1986979630 hasLocation W19869796301 @default.

• next