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• W1986981505 abstract "Background: In this multi-center trial, we investigated the safety, feasibility, and efficacy of endoscopic radiofrequency energy (RFe) delivery to the smooth muscle of the gastroesophageal junction (GEJ) for the treatment of GERD. Methods: We studied patients with chronic heartburn, acid exposure time >4% or DeMeester score>14.7, and daily anti-secretory requirement. We delivered RFe (outpatient, conscious sedation) with a 4-needle catheter and thermocouple-controlled generator to create rings of thermal lesions in the GEJ. Before and 6 months after RFe we assessed: quality of life (QOL) with SF-36 (general) and GERD-QOL (specific) surveys, medication use, endoscopy, esophageal motility and 24-hr pH. Results: Twenty males and 8 females (mean age 50, range 22-67 yrs), underwent RFe delivery (mean RFe time=24 min). There were no significant adverse events. Upon entry, all patients required daily anti-secretory drugs (14 PPI bid, 12 PPI qd, 2 H2RA). At 6 mos, 22 patients (79%) are off all anti-secretory drugs (22 no drug, 2 PPI qd, 4 H2RA). 24-hr pH (% time pH<4.0) improved in 75% of patients. Grade I and II esophagitis was present in 11 patients prior to therapy and in 3 patients at 6 mos. Conclusion: RFe is a promising new technique for GERD because it safely improves symptoms and QOL scores in all patients, eliminates the need for anti-secretory drugs in 79%, and improves pH scores in 75% of patients. Background: In this multi-center trial, we investigated the safety, feasibility, and efficacy of endoscopic radiofrequency energy (RFe) delivery to the smooth muscle of the gastroesophageal junction (GEJ) for the treatment of GERD. Methods: We studied patients with chronic heartburn, acid exposure time >4% or DeMeester score>14.7, and daily anti-secretory requirement. We delivered RFe (outpatient, conscious sedation) with a 4-needle catheter and thermocouple-controlled generator to create rings of thermal lesions in the GEJ. Before and 6 months after RFe we assessed: quality of life (QOL) with SF-36 (general) and GERD-QOL (specific) surveys, medication use, endoscopy, esophageal motility and 24-hr pH. Results: Twenty males and 8 females (mean age 50, range 22-67 yrs), underwent RFe delivery (mean RFe time=24 min). There were no significant adverse events. Upon entry, all patients required daily anti-secretory drugs (14 PPI bid, 12 PPI qd, 2 H2RA). At 6 mos, 22 patients (79%) are off all anti-secretory drugs (22 no drug, 2 PPI qd, 4 H2RA). 24-hr pH (% time pH<4.0) improved in 75% of patients. Grade I and II esophagitis was present in 11 patients prior to therapy and in 3 patients at 6 mos. Conclusion: RFe is a promising new technique for GERD because it safely improves symptoms and QOL scores in all patients, eliminates the need for anti-secretory drugs in 79%, and improves pH scores in 75% of patients." @default.
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• W1986981505 date "2000-04-01" @default.
• W1986981505 modified "2023-09-25" @default.
• W1986981505 title "4909 Radiofrequency energy application to the gastroesophageal junction for the treatment of gastroesophageal reflux disease." @default.
• W1986981505 doi "https://doi.org/10.1016/s0016-5107(00)14606-1" @default.
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