FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986987908> ?p ?o ?g. }

• W1986987908 endingPage "1171" @default.
• W1986987908 startingPage "1163" @default.
• W1986987908 abstract "Iron overload syndromes include a wide spectrum of genetic and acquired conditions. Recent studies suggest suppressed hepcidin synthesis in the liver to be the molecular basis of hemochromatosis. However, a liver with acquired iron overload synthesizes an adequate amount of hepcidin. Thus, hepcidin could function as a biochemical marker for differential diagnosis of iron overload syndromes. We measured serum iron parameters and hepcidin-25 levels followed by sequencing HFE, HJV, HAMP, TFR2, and SLC40A1 genes in 13 Japanese patients with iron overload syndromes. In addition, we performed direct measurement of serum hepcidin-25 levels using liquid chromatography–tandem mass spectrometry in 3 Japanese patients with aceruloplasminemia and 4 Italians with HFE hemochromatosis. One patient with HJV hemochromatosis, 2 with TFR2 hemochromatosis, and 3 with ferroportin disease were found among the 13 Japanese patients. The remaining 7 Japanese patients showed no evidence for genetic basis of iron overload syndrome. As far as the serum hepcidin-25 was concerned, seven patients with hemochromatosis and 3 with aceruloplasminemia showed markedly decreased serum hepcidin-25 levels. In contrast, 3 patients with ferroportin disease and 7 with secondary iron overload syndromes showed serum hepcidin levels parallel to their hyperferritinemia. Patients with iron overload syndromes were divided into 2 phenotypes presenting as low and high hepcidinemia. These were then associated with their genotypes. Determining serum hepcidin-25 levels may aid differential diagnosis of iron overload syndromes prior to genetic analysis." @default.
• W1986987908 created "2016-06-24" @default.
• W1986987908 creator A5000300079 @default.
• W1986987908 creator A5000877482 @default.
• W1986987908 creator A5005074072 @default.
• W1986987908 creator A5010573723 @default.
• W1986987908 creator A5012940655 @default.
• W1986987908 creator A5015289084 @default.
• W1986987908 creator A5015923715 @default.
• W1986987908 creator A5016190886 @default.
• W1986987908 creator A5023742411 @default.
• W1986987908 creator A5026767989 @default.
• W1986987908 creator A5036265124 @default.
• W1986987908 creator A5040981230 @default.
• W1986987908 creator A5045930743 @default.
• W1986987908 creator A5054075713 @default.
• W1986987908 creator A5055467060 @default.
• W1986987908 creator A5064539753 @default.
• W1986987908 creator A5084410022 @default.
• W1986987908 creator A5091317308 @default.
• W1986987908 date "2010-06-09" @default.
• W1986987908 modified "2023-09-28" @default.
• W1986987908 title "Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders" @default.
• W1986987908 cites W1507879124 @default.
• W1986987908 cites W1522974031 @default.
• W1986987908 cites W1761222131 @default.
• W1986987908 cites W1967769185 @default.
• W1986987908 cites W1970739518 @default.
• W1986987908 cites W1973313690 @default.
• W1986987908 cites W1976726664 @default.
• W1986987908 cites W1980042430 @default.
• W1986987908 cites W1983373106 @default.
• W1986987908 cites W1999149952 @default.
• W1986987908 cites W2002605005 @default.
• W1986987908 cites W2011115926 @default.
• W1986987908 cites W2015746024 @default.
• W1986987908 cites W2017958782 @default.
• W1986987908 cites W2018854948 @default.
• W1986987908 cites W2025063713 @default.
• W1986987908 cites W2025158365 @default.
• W1986987908 cites W2026661079 @default.
• W1986987908 cites W2028863998 @default.
• W1986987908 cites W2031557560 @default.
• W1986987908 cites W2032533705 @default.
• W1986987908 cites W2035390231 @default.
• W1986987908 cites W2038831113 @default.
• W1986987908 cites W2038944724 @default.
• W1986987908 cites W2039072637 @default.
• W1986987908 cites W2053757489 @default.
• W1986987908 cites W2056282179 @default.
• W1986987908 cites W2059080581 @default.
• W1986987908 cites W2063072742 @default.
• W1986987908 cites W2088903681 @default.
• W1986987908 cites W2090165219 @default.
• W1986987908 cites W2091769889 @default.
• W1986987908 cites W2107690447 @default.
• W1986987908 cites W2112225163 @default.
• W1986987908 cites W2116064842 @default.
• W1986987908 cites W2128704908 @default.
• W1986987908 cites W2130382251 @default.
• W1986987908 cites W2131823953 @default.
• W1986987908 cites W2132544275 @default.
• W1986987908 cites W2138848400 @default.
• W1986987908 cites W2148362837 @default.
• W1986987908 cites W2159886045 @default.
• W1986987908 cites W2161998284 @default.
• W1986987908 cites W2166890625 @default.
• W1986987908 cites W2170375210 @default.
• W1986987908 cites W4254938795 @default.
• W1986987908 doi "https://doi.org/10.1007/s00535-010-0259-8" @default.
• W1986987908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20533066" @default.
• W1986987908 hasPublicationYear "2010" @default.
• W1986987908 type Work @default.
• W1986987908 sameAs 1986987908 @default.
• W1986987908 citedByCount "52" @default.
• W1986987908 countsByYear W19869879082012 @default.
• W1986987908 countsByYear W19869879082013 @default.
• W1986987908 countsByYear W19869879082014 @default.
• W1986987908 countsByYear W19869879082015 @default.
• W1986987908 countsByYear W19869879082016 @default.
• W1986987908 countsByYear W19869879082017 @default.
• W1986987908 countsByYear W19869879082018 @default.
• W1986987908 countsByYear W19869879082019 @default.
• W1986987908 countsByYear W19869879082020 @default.
• W1986987908 countsByYear W19869879082021 @default.
• W1986987908 countsByYear W19869879082022 @default.
• W1986987908 countsByYear W19869879082023 @default.
• W1986987908 crossrefType "journal-article" @default.
• W1986987908 hasAuthorship W1986987908A5000300079 @default.
• W1986987908 hasAuthorship W1986987908A5000877482 @default.
• W1986987908 hasAuthorship W1986987908A5005074072 @default.
• W1986987908 hasAuthorship W1986987908A5010573723 @default.
• W1986987908 hasAuthorship W1986987908A5012940655 @default.
• W1986987908 hasAuthorship W1986987908A5015289084 @default.
• W1986987908 hasAuthorship W1986987908A5015923715 @default.
• W1986987908 hasAuthorship W1986987908A5016190886 @default.
• W1986987908 hasAuthorship W1986987908A5023742411 @default.
• W1986987908 hasAuthorship W1986987908A5026767989 @default.

• next