FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986989785> ?p ?o ?g. }

• W1986989785 abstract "The virulence factor PgtE is an outer membrane protease (omptin) of the zoonotic pathogen Salmonella enterica that causes diseases ranging from gastroenteritis to severe enteric fever. It is surface exposed in bacteria that have a short-chain, i.e. rough LPS, as observed e.g. in bacteria residing inside macrophages or just emerging from them. We investigated whether PgtE cleaves the complement factors B (B) and H (H), key proteins controlling formation and inactivation of the complement protein C3b and thereby the activity of the complement system. S. enterica serovar Typhimurium or omptin-expressing recombinant E. coli bacteria were incubated with purified human complement proteins or recombinant H fragments. PgtE cleaved both B and H, whereas its close homolog Pla of Yersinia pestis cleaved only H. H was cleaved at both N- and C-termini, while the central region resisted proteolysis. Because of multiple effects of PgtE on complement components (cleavage of C3, C3b, B and H) we assessed its effect on the opsonophagocytosis of Salmonella. In human serum, C3 cleavage was dependent on proteolytically active PgtE. Human neutrophils interacted less with serum-opsonized FITC-stained S. enterica 14028R than with the isogenic ΔpgtE strain, as analyzed by flow cytometry. In conclusion, cleavage of B and H by PgtE, together with C3 cleavage, affects the C3-mediated recognition of S. enterica by human neutrophils, thus thwarting the immune protection against Salmonella." @default.
• W1986989785 created "2016-06-24" @default.
• W1986989785 creator A5025820462 @default.
• W1986989785 creator A5032350647 @default.
• W1986989785 creator A5033403912 @default.
• W1986989785 date "2015-02-06" @default.
• W1986989785 modified "2023-10-10" @default.
• W1986989785 title "The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H" @default.
• W1986989785 cites W1479947925 @default.
• W1986989785 cites W1569686393 @default.
• W1986989785 cites W1575381144 @default.
• W1986989785 cites W1827417957 @default.
• W1986989785 cites W1922668255 @default.
• W1986989785 cites W195863976 @default.
• W1986989785 cites W1963608283 @default.
• W1986989785 cites W1973294535 @default.
• W1986989785 cites W1979248837 @default.
• W1986989785 cites W1985201525 @default.
• W1986989785 cites W1992861835 @default.
• W1986989785 cites W1997494954 @default.
• W1986989785 cites W2005150109 @default.
• W1986989785 cites W2006130551 @default.
• W1986989785 cites W2007730535 @default.
• W1986989785 cites W2008911461 @default.
• W1986989785 cites W2012760052 @default.
• W1986989785 cites W2014477644 @default.
• W1986989785 cites W2019785415 @default.
• W1986989785 cites W2028944012 @default.
• W1986989785 cites W2031895664 @default.
• W1986989785 cites W2033342586 @default.
• W1986989785 cites W2034408518 @default.
• W1986989785 cites W2072617582 @default.
• W1986989785 cites W2080033753 @default.
• W1986989785 cites W2088140700 @default.
• W1986989785 cites W2090328264 @default.
• W1986989785 cites W2095444125 @default.
• W1986989785 cites W2102898060 @default.
• W1986989785 cites W2118932941 @default.
• W1986989785 cites W2120926466 @default.
• W1986989785 cites W2122075336 @default.
• W1986989785 cites W2128409590 @default.
• W1986989785 cites W2128420632 @default.
• W1986989785 cites W2129566418 @default.
• W1986989785 cites W2132650423 @default.
• W1986989785 cites W2136648677 @default.
• W1986989785 cites W2137578797 @default.
• W1986989785 cites W2142999073 @default.
• W1986989785 cites W2144604037 @default.
• W1986989785 cites W2145638464 @default.
• W1986989785 cites W2145853372 @default.
• W1986989785 cites W2149184487 @default.
• W1986989785 cites W2149220723 @default.
• W1986989785 cites W2155828191 @default.
• W1986989785 cites W2156270624 @default.
• W1986989785 cites W2158978517 @default.
• W1986989785 cites W2160404680 @default.
• W1986989785 cites W2164383866 @default.
• W1986989785 cites W2166578585 @default.
• W1986989785 cites W2167109916 @default.
• W1986989785 cites W2167959271 @default.
• W1986989785 cites W2409249692 @default.
• W1986989785 cites W4248441936 @default.
• W1986989785 cites W4250985797 @default.
• W1986989785 doi "https://doi.org/10.3389/fmicb.2015.00063" @default.
• W1986989785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4319491" @default.
• W1986989785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25705210" @default.
• W1986989785 hasPublicationYear "2015" @default.
• W1986989785 type Work @default.
• W1986989785 sameAs 1986989785 @default.
• W1986989785 citedByCount "35" @default.
• W1986989785 countsByYear W19869897852015 @default.
• W1986989785 countsByYear W19869897852016 @default.
• W1986989785 countsByYear W19869897852017 @default.
• W1986989785 countsByYear W19869897852018 @default.
• W1986989785 countsByYear W19869897852019 @default.
• W1986989785 countsByYear W19869897852020 @default.
• W1986989785 countsByYear W19869897852021 @default.
• W1986989785 countsByYear W19869897852022 @default.
• W1986989785 countsByYear W19869897852023 @default.
• W1986989785 crossrefType "journal-article" @default.
• W1986989785 hasAuthorship W1986989785A5025820462 @default.
• W1986989785 hasAuthorship W1986989785A5032350647 @default.
• W1986989785 hasAuthorship W1986989785A5033403912 @default.
• W1986989785 hasBestOaLocation W19869897853 @default.
• W1986989785 hasConcept C104317684 @default.
• W1986989785 hasConcept C111684460 @default.
• W1986989785 hasConcept C138873322 @default.
• W1986989785 hasConcept C14356644 @default.
• W1986989785 hasConcept C146587185 @default.
• W1986989785 hasConcept C160448771 @default.
• W1986989785 hasConcept C171279029 @default.
• W1986989785 hasConcept C179369057 @default.
• W1986989785 hasConcept C181199279 @default.
• W1986989785 hasConcept C189446657 @default.
• W1986989785 hasConcept C203014093 @default.
• W1986989785 hasConcept C2776714187 @default.
• W1986989785 hasConcept C2778222588 @default.
• W1986989785 hasConcept C2778910516 @default.
• W1986989785 hasConcept C2779607309 @default.
• W1986989785 hasConcept C2781065037 @default.

• next