Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987007789> ?p ?o ?g. }
- W1987007789 endingPage "67" @default.
- W1987007789 startingPage "51" @default.
- W1987007789 abstract "The contribution of in vivo monitoring to the study of glutamate release is reviewed. Physiological stimulation increases both glutamate and aspartate in the extracellular compartment of the brain and both amino acids show Ca2+-dependent K+-evoked release. However, the finding that only glutamate is stored in synaptic vesicles implies that glutamate is the excitatory transmitter. Released glutamate is taken up into both neurones and glia by glutamate transporters. Uptake of glutamate, in addition to clearing the synapse, has a number of additional functions. Uptake into glia leads to the release of glutamine, which is involved in the recycling of transmitter glutamate; uptake into both neurones and glia leads to the release of ascorbate; uptake into glia leads to an increase glycolysis and export of lactate, an energy substrate for neuronal metabolism. Reversal of the glutamate transporter accounts for the parallel release of glutamate and aspartate from the cytoplasmic compartment. The basal concentration of extracellular glutamate is in the micromolar range. Such levels could lead to desensitisation of both NMDA and non-NMDA receptors. The functional implications of the level of basal glutamate are difficult to assess at present in view of the existence of multiple glutamate receptor subunits with different functional properties and distributions." @default.
- W1987007789 created "2016-06-24" @default.
- W1987007789 creator A5009980408 @default.
- W1987007789 date "1995-11-01" @default.
- W1987007789 modified "2023-09-23" @default.
- W1987007789 title "Physiological release of excitatory amino acids" @default.
- W1987007789 cites W13918475 @default.
- W1987007789 cites W1490043608 @default.
- W1987007789 cites W1527818534 @default.
- W1987007789 cites W1537179351 @default.
- W1987007789 cites W1541602774 @default.
- W1987007789 cites W1563937254 @default.
- W1987007789 cites W1629129452 @default.
- W1987007789 cites W1957209685 @default.
- W1987007789 cites W1965351558 @default.
- W1987007789 cites W1965377078 @default.
- W1987007789 cites W1968213692 @default.
- W1987007789 cites W1968470516 @default.
- W1987007789 cites W1969400861 @default.
- W1987007789 cites W1969561622 @default.
- W1987007789 cites W1973449790 @default.
- W1987007789 cites W1973922279 @default.
- W1987007789 cites W1974588666 @default.
- W1987007789 cites W1975276395 @default.
- W1987007789 cites W1977448784 @default.
- W1987007789 cites W1977451474 @default.
- W1987007789 cites W1977470728 @default.
- W1987007789 cites W1980829665 @default.
- W1987007789 cites W1980979304 @default.
- W1987007789 cites W1981102082 @default.
- W1987007789 cites W1982626792 @default.
- W1987007789 cites W1982879661 @default.
- W1987007789 cites W1985223881 @default.
- W1987007789 cites W1986617719 @default.
- W1987007789 cites W1987080089 @default.
- W1987007789 cites W1989442300 @default.
- W1987007789 cites W1991701465 @default.
- W1987007789 cites W1993391624 @default.
- W1987007789 cites W1994664430 @default.
- W1987007789 cites W1995827569 @default.
- W1987007789 cites W1996700357 @default.
- W1987007789 cites W1997658056 @default.
- W1987007789 cites W1997809327 @default.
- W1987007789 cites W1997990928 @default.
- W1987007789 cites W1998611747 @default.
- W1987007789 cites W2003059369 @default.
- W1987007789 cites W2003184890 @default.
- W1987007789 cites W2003410399 @default.
- W1987007789 cites W2005952891 @default.
- W1987007789 cites W2007200514 @default.
- W1987007789 cites W2007915384 @default.
- W1987007789 cites W2008524165 @default.
- W1987007789 cites W2009812273 @default.
- W1987007789 cites W2010310036 @default.
- W1987007789 cites W2013845131 @default.
- W1987007789 cites W2016522514 @default.
- W1987007789 cites W2017129540 @default.
- W1987007789 cites W2017467140 @default.
- W1987007789 cites W2018149549 @default.
- W1987007789 cites W2020388103 @default.
- W1987007789 cites W2021581599 @default.
- W1987007789 cites W2021950684 @default.
- W1987007789 cites W2023182720 @default.
- W1987007789 cites W2023931571 @default.
- W1987007789 cites W2025114609 @default.
- W1987007789 cites W2025399675 @default.
- W1987007789 cites W2026294888 @default.
- W1987007789 cites W2026734411 @default.
- W1987007789 cites W2027973870 @default.
- W1987007789 cites W2028093765 @default.
- W1987007789 cites W2028119312 @default.
- W1987007789 cites W2029288179 @default.
- W1987007789 cites W2029364696 @default.
- W1987007789 cites W2029862807 @default.
- W1987007789 cites W2029899504 @default.
- W1987007789 cites W2030343278 @default.
- W1987007789 cites W2032534882 @default.
- W1987007789 cites W2032680915 @default.
- W1987007789 cites W2035892816 @default.
- W1987007789 cites W2036495604 @default.
- W1987007789 cites W2041725620 @default.
- W1987007789 cites W2043828718 @default.
- W1987007789 cites W2044669080 @default.
- W1987007789 cites W2048509522 @default.
- W1987007789 cites W2049192908 @default.
- W1987007789 cites W2049291384 @default.
- W1987007789 cites W2053209546 @default.
- W1987007789 cites W2053530999 @default.
- W1987007789 cites W2053739364 @default.
- W1987007789 cites W2054650020 @default.
- W1987007789 cites W2055137643 @default.
- W1987007789 cites W2055630428 @default.
- W1987007789 cites W2058314504 @default.
- W1987007789 cites W2059939266 @default.
- W1987007789 cites W2063261415 @default.
- W1987007789 cites W2064888140 @default.
- W1987007789 cites W2065169750 @default.
- W1987007789 cites W2066266085 @default.