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• W1987014780 abstract "Activation of mu opioid receptors within the ventral tegmental area (VTA) can produce reward through the inhibition of GABAergic inputs. GABAergic neurons in the ventral pallidum (VP) provide a major input to VTA neurons. To determine the specific VTA neuronal targets of VP afferents and their sensitivity to mu opioid receptor agonists, we virally expressed channel rhodopsin (ChR2) in rat VP neurons and optogenetically activated their terminals in the VTA. Light activation of VP neuron terminals elicited GABAergic IPSCs in both dopamine (DA) and non-DA VTA neurons, and these IPSCs were inhibited by the mu opioid receptor agonist DAMGO. In addition, using a fluorescent retrograde marker to identify VTA-projecting VP neurons, we found them to be hyperpolarized by DAMGO. Both of these actions decrease GABAergic input onto VTA neurons, revealing two mechanisms by which endogenous or exogenous opioids can activate VTA neurons, including DA neurons." @default.
• W1987014780 created "2016-06-24" @default.
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• W1987014780 date "2013-04-10" @default.
• W1987014780 modified "2023-10-18" @default.
• W1987014780 title "Opioid Modulation of Ventral Pallidal Afferents to Ventral Tegmental Area Neurons" @default.
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• W1987014780 doi "https://doi.org/10.1523/jneurosci.0178-13.2013" @default.
• W1987014780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3865539" @default.
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