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- W1987018981 abstract "Le tiagabine, un antiépileptique de deuxième génération, est commercialisée en France depuis 1997. Elle est aussi prescrite, hors AMM, dans le traitement de l’anxiété. Les études permettant d’argumenter une relation exposition efficacité ou toxicité sont peu nombreuses, mais il existe des variations intra et inter individuelles importantes dans les concentrations sériques. L’insuffisance hépatique nécessite une adaptation de posologie. Chez les patients traités à dose thérapeutique, les concentrations sériques sont comprises entre 20 et 100 μg/L soit 50–250 nmol/L. Pour cette molécule, le niveau de preuve de l’intérêt du STP a été évalué à : restant à évaluer Tiagabine, a second-generation anticonvulsant drug, is marketed in France since 1997. It is also prescribed outside marketing authorization in the treatment of anxiety. They are few studies allowing arguing a relation exposure efficiency or toxicity, but intra and inter individual important variations in serum concentrations are described. Hepatic insufficiency requires a dose adaptation. In patients treated with therapeutic dose, serum levels are between 20 and 100 μg/L (50–250 nmol/L) For this molecule, the level of proof of the interest of TDM was estimated in: remaining to estimate." @default.
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- W1987018981 date "2010-01-01" @default.
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- W1987018981 title "Suivi thérapeutique pharmacologique de la tiagabine" @default.
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- W1987018981 doi "https://doi.org/10.2515/therapie/2009065" @default.
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