Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987029196> ?p ?o ?g. }
- W1987029196 endingPage "193" @default.
- W1987029196 startingPage "186" @default.
- W1987029196 abstract "Mutations of the von Hippel-Lindau (VHL) gene are considered critical for the initiation of clear cell renal cell carcinoma. The VHL protein is involved in regulation of the cell cycle and neo-vascularization. In this study, the association of VHL mutations with tumour cell proliferation, angiogenesis, and clinical outcome was analysed in 113 clear cell renal cell carcinomas. The degree of angiogenesis and tumour cell proliferation was immunohistochemically determined by counting microvessels (microvessel density, anti-CD34 antibody) and cells with proliferating activity (Ki-67 labelling index, MIB-1 antibody). Forty-eight different VHL sequence alterations were found in 38 of 113 patients (34%) by direct sequencing. Nineteen VHL mutations were frameshifts and nonsense mutations, predicted to change the open reading frame of VHL. These ‘loss-of-function’ mutations correlated with worse prognosis in univariate analysis (p=0.02). Tumour grade, stage, microvessel density, and tumour cell proliferation were not associated with VHL alterations. These findings may indicate that ‘loss-of-function’ VHL mutations are involved in the progression of a clear cell renal cell carcinoma subset, whereas regulation of angiogenesis and proliferation of renal carcinoma in vivo is apparently not directly influenced by VHL alterations. Copyright © 2001 John Wiley & Sons, Ltd." @default.
- W1987029196 created "2016-06-24" @default.
- W1987029196 creator A5007249612 @default.
- W1987029196 creator A5032481941 @default.
- W1987029196 creator A5053110552 @default.
- W1987029196 creator A5062696264 @default.
- W1987029196 creator A5065342455 @default.
- W1987029196 creator A5067223235 @default.
- W1987029196 creator A5076510325 @default.
- W1987029196 creator A5080911703 @default.
- W1987029196 creator A5040191679 @default.
- W1987029196 date "2002-01-01" @default.
- W1987029196 modified "2023-10-17" @default.
- W1987029196 title "VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma" @default.
- W1987029196 cites W1557967195 @default.
- W1987029196 cites W1749022239 @default.
- W1987029196 cites W181147267 @default.
- W1987029196 cites W1963533810 @default.
- W1987029196 cites W1964382251 @default.
- W1987029196 cites W1978173977 @default.
- W1987029196 cites W1989040551 @default.
- W1987029196 cites W2010160635 @default.
- W1987029196 cites W2013256551 @default.
- W1987029196 cites W2024022674 @default.
- W1987029196 cites W2025255125 @default.
- W1987029196 cites W2027669169 @default.
- W1987029196 cites W2031485253 @default.
- W1987029196 cites W2034822725 @default.
- W1987029196 cites W2039559097 @default.
- W1987029196 cites W2043285040 @default.
- W1987029196 cites W2044247340 @default.
- W1987029196 cites W2050003881 @default.
- W1987029196 cites W2052271345 @default.
- W1987029196 cites W2054636737 @default.
- W1987029196 cites W2068555261 @default.
- W1987029196 cites W2071872174 @default.
- W1987029196 cites W2101628607 @default.
- W1987029196 cites W2112775523 @default.
- W1987029196 cites W2125505202 @default.
- W1987029196 cites W2126486896 @default.
- W1987029196 cites W2142173484 @default.
- W1987029196 cites W2163793345 @default.
- W1987029196 cites W2171875350 @default.
- W1987029196 cites W3087720232 @default.
- W1987029196 cites W4297119881 @default.
- W1987029196 cites W4298413103 @default.
- W1987029196 cites W4361866883 @default.
- W1987029196 doi "https://doi.org/10.1002/path.1034" @default.
- W1987029196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11793370" @default.
- W1987029196 hasPublicationYear "2002" @default.
- W1987029196 type Work @default.
- W1987029196 sameAs 1987029196 @default.
- W1987029196 citedByCount "206" @default.
- W1987029196 countsByYear W19870291962012 @default.
- W1987029196 countsByYear W19870291962013 @default.
- W1987029196 countsByYear W19870291962014 @default.
- W1987029196 countsByYear W19870291962015 @default.
- W1987029196 countsByYear W19870291962016 @default.
- W1987029196 countsByYear W19870291962017 @default.
- W1987029196 countsByYear W19870291962018 @default.
- W1987029196 countsByYear W19870291962019 @default.
- W1987029196 countsByYear W19870291962020 @default.
- W1987029196 countsByYear W19870291962021 @default.
- W1987029196 countsByYear W19870291962022 @default.
- W1987029196 countsByYear W19870291962023 @default.
- W1987029196 crossrefType "journal-article" @default.
- W1987029196 hasAuthorship W1987029196A5007249612 @default.
- W1987029196 hasAuthorship W1987029196A5032481941 @default.
- W1987029196 hasAuthorship W1987029196A5040191679 @default.
- W1987029196 hasAuthorship W1987029196A5053110552 @default.
- W1987029196 hasAuthorship W1987029196A5062696264 @default.
- W1987029196 hasAuthorship W1987029196A5065342455 @default.
- W1987029196 hasAuthorship W1987029196A5067223235 @default.
- W1987029196 hasAuthorship W1987029196A5076510325 @default.
- W1987029196 hasAuthorship W1987029196A5080911703 @default.
- W1987029196 hasConcept C10205521 @default.
- W1987029196 hasConcept C121608353 @default.
- W1987029196 hasConcept C142724271 @default.
- W1987029196 hasConcept C1491633281 @default.
- W1987029196 hasConcept C2777472916 @default.
- W1987029196 hasConcept C2778264664 @default.
- W1987029196 hasConcept C2778560582 @default.
- W1987029196 hasConcept C2780394083 @default.
- W1987029196 hasConcept C2781278892 @default.
- W1987029196 hasConcept C28328180 @default.
- W1987029196 hasConcept C2910938049 @default.
- W1987029196 hasConcept C29537977 @default.
- W1987029196 hasConcept C502942594 @default.
- W1987029196 hasConcept C54355233 @default.
- W1987029196 hasConcept C555283112 @default.
- W1987029196 hasConcept C62112901 @default.
- W1987029196 hasConcept C71924100 @default.
- W1987029196 hasConcept C86803240 @default.
- W1987029196 hasConceptScore W1987029196C10205521 @default.
- W1987029196 hasConceptScore W1987029196C121608353 @default.
- W1987029196 hasConceptScore W1987029196C142724271 @default.
- W1987029196 hasConceptScore W1987029196C1491633281 @default.
- W1987029196 hasConceptScore W1987029196C2777472916 @default.