Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987029683> ?p ?o ?g. }
- W1987029683 endingPage "683" @default.
- W1987029683 startingPage "672" @default.
- W1987029683 abstract "Morphological changes in the hepatic sinusoid with old age are increasingly recognized. These include thickening and defenestration of the liver sinusoidal endothelial cell, sporadic deposition of collagen and basal lamina in the extracellular space of Disse, and increased numbers of fat engorged, nonactivated stellate cells. In addition, there is endothelial up-regulation of von Willebrand factor and ICAM-1 with reduced expression of caveolin-1. These changes have been termed age-related pseudocapillarization. The effects of old age on Kupffer cells are inconsistent, but impaired responsiveness is likely. There are functional implications of these aging changes in the hepatic sinusoid. There is reduced sinusoidal perfusion, which will impair the hepatic clearance of highly extracted substrates. Blood clearance of a variety of waste macromolecules takes place in liver sinusoidal endothelial cells (LSECs). Previous studies indicated either that aging had no effect, or reduced the endocytic capacity of LSECs. However, a recent study in mice showed reduced endocytosis in pericentral regions of the liver lobules. Reduced endocytosis may increase systemic exposure to potential harmful waste macromolecules such as advanced glycation end products Loss of fenestrations leads to impaired transfer of lipoproteins from blood to hepatocytes. This provides a mechanism for impaired chylomicron remnant clearance and postprandial hyperlipidemia associated with old age. Given the extensive range of substrates metabolized by the liver, age-related changes in the hepatic sinusoid and microcirculation have important systemic implications for aging and age-related diseases. Anat Rec, 291:672–683, 2008. © 2008 Wiley-Liss, Inc." @default.
- W1987029683 created "2016-06-24" @default.
- W1987029683 creator A5001736556 @default.
- W1987029683 creator A5012096834 @default.
- W1987029683 creator A5038923785 @default.
- W1987029683 creator A5046485693 @default.
- W1987029683 creator A5050395647 @default.
- W1987029683 creator A5059503327 @default.
- W1987029683 creator A5079413998 @default.
- W1987029683 creator A5086295584 @default.
- W1987029683 date "2008-01-01" @default.
- W1987029683 modified "2023-10-18" @default.
- W1987029683 title "Old Age and the Hepatic Sinusoid" @default.
- W1987029683 cites W102012657 @default.
- W1987029683 cites W1489537708 @default.
- W1987029683 cites W1498929362 @default.
- W1987029683 cites W1519847653 @default.
- W1987029683 cites W1524139871 @default.
- W1987029683 cites W1564372585 @default.
- W1987029683 cites W1608488562 @default.
- W1987029683 cites W1924680600 @default.
- W1987029683 cites W1966234811 @default.
- W1987029683 cites W1966426192 @default.
- W1987029683 cites W1967043259 @default.
- W1987029683 cites W1970368657 @default.
- W1987029683 cites W1971153037 @default.
- W1987029683 cites W1972438132 @default.
- W1987029683 cites W1973824606 @default.
- W1987029683 cites W1977401467 @default.
- W1987029683 cites W1978171462 @default.
- W1987029683 cites W1979421433 @default.
- W1987029683 cites W1979735072 @default.
- W1987029683 cites W1985280536 @default.
- W1987029683 cites W1988853236 @default.
- W1987029683 cites W1991905653 @default.
- W1987029683 cites W1992268549 @default.
- W1987029683 cites W1997280214 @default.
- W1987029683 cites W1997412308 @default.
- W1987029683 cites W1998011660 @default.
- W1987029683 cites W1999354809 @default.
- W1987029683 cites W2005380091 @default.
- W1987029683 cites W2006802887 @default.
- W1987029683 cites W2007037970 @default.
- W1987029683 cites W2007198833 @default.
- W1987029683 cites W2008357590 @default.
- W1987029683 cites W2011359102 @default.
- W1987029683 cites W2016846453 @default.
- W1987029683 cites W2018998872 @default.
- W1987029683 cites W2020371789 @default.
- W1987029683 cites W2021357255 @default.
- W1987029683 cites W2022389789 @default.
- W1987029683 cites W2023545075 @default.
- W1987029683 cites W2023552749 @default.
- W1987029683 cites W2026647673 @default.
- W1987029683 cites W2026949784 @default.
- W1987029683 cites W2028612481 @default.
- W1987029683 cites W2029505204 @default.
- W1987029683 cites W2030207517 @default.
- W1987029683 cites W2035985265 @default.
- W1987029683 cites W2036023160 @default.
- W1987029683 cites W2037555606 @default.
- W1987029683 cites W2047190365 @default.
- W1987029683 cites W2047354583 @default.
- W1987029683 cites W2050051573 @default.
- W1987029683 cites W2054515896 @default.
- W1987029683 cites W2074034274 @default.
- W1987029683 cites W2076375713 @default.
- W1987029683 cites W2077868295 @default.
- W1987029683 cites W2078296200 @default.
- W1987029683 cites W2079118973 @default.
- W1987029683 cites W2079675707 @default.
- W1987029683 cites W2080235329 @default.
- W1987029683 cites W2081643556 @default.
- W1987029683 cites W2082424531 @default.
- W1987029683 cites W2087633223 @default.
- W1987029683 cites W2091119704 @default.
- W1987029683 cites W2094595997 @default.
- W1987029683 cites W2095167553 @default.
- W1987029683 cites W2099547258 @default.
- W1987029683 cites W2112919574 @default.
- W1987029683 cites W2113552020 @default.
- W1987029683 cites W2123165167 @default.
- W1987029683 cites W2123888680 @default.
- W1987029683 cites W2125121177 @default.
- W1987029683 cites W2125826913 @default.
- W1987029683 cites W2134041267 @default.
- W1987029683 cites W2135613921 @default.
- W1987029683 cites W2146270980 @default.
- W1987029683 cites W2147911026 @default.
- W1987029683 cites W2154249136 @default.
- W1987029683 cites W2157886160 @default.
- W1987029683 cites W2159164156 @default.
- W1987029683 cites W2161997854 @default.
- W1987029683 cites W2162372723 @default.
- W1987029683 cites W2315377258 @default.
- W1987029683 cites W2419702484 @default.
- W1987029683 cites W3015544325 @default.
- W1987029683 cites W73770597 @default.