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• W1987030907 abstract "Guanine nucleotide-binding protein (G protein)-mediated signal transduction constitutes a common mechanism by which cells receive and respond to a diverse set of environmental signals. Many of the signals involved in the developmental life cycle of the slime mold Dictyostelium have been postulated to be transduced by such pathways and, in some cases, these pathways have been demonstrated to be dependent on specific G proteins. Using the polymerase chain reaction, we have identified two additional Dictyostelium G alpha genes, G alpha 4 and G alpha 5, that are developmentally regulated. Transcripts from both of these genes are primarily expressed during the multicellular stages of development, suggesting possible roles in cell differentiation or morphogenesis. The entire G alpha 4 gene was sequenced and found to encode a protein consisting of 345 amino acids. The G alpha 4 subunit is homologous to other previously identified G alpha subunits, including the Dictyostelium G alpha 1 (43% identity) and G alpha 2 (41% identity) subunits. However, the G alpha 4 subunit contains some unusual sequence divergences in residues highly conserved among most eukaryotic G alpha subunits, suggesting that G alpha 4 may be a member of another class of G alpha subunits." @default.
• W1987030907 created "2016-06-24" @default.
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• W1987030907 date "1991-09-15" @default.
• W1987030907 modified "2023-09-26" @default.
• W1987030907 title "Identification of Dictyostelium G alpha genes expressed during multicellular development." @default.
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• W1987030907 doi "https://doi.org/10.1073/pnas.88.18.8213" @default.
• W1987030907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/52477" @default.
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• W1987030907 hasPublicationYear "1991" @default.
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