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- W1987036240 endingPage "473" @default.
- W1987036240 startingPage "457" @default.
- W1987036240 abstract "Alcohol consumption leads to numerous morphological, biochemical and functional changes in skeletal and cardiac muscle. One such change observed in both tissues after either acute alcohol intoxication or chronic alcohol consumption is a characteristic decrease in the rate of protein synthesis. A decrease in translation efficiency appears to be responsible for at least part of the reduction. This review highlights advances in determining the molecular mechanisms by which alcohol impairs protein synthesis and places these observations in context of earlier studies on alcoholic myopathy. Both acute and chronic alcohol administration impairs translational control by modulating various aspects of peptide-chain initiation. Moreover, this alcohol-induced impairment in initiation is associated with a decreased availability of eukaryotic initiation factor (eIF) 4E in striated muscle, as evidenced by an increase in the amount of the inactive eIF4E.4E-BP1 complex and decrease in the active eIF4E.eIF4G complex. In contrast, alcohol does not produce consistent alterations in the control of translation initiation by the eIF2 system. The etiology of these changes remain unresolved. However, defects in the availability or effectiveness of various anabolic hormones, particularly insulin-like growth factor-I, are consistent with the alcohol-induced decrease in protein synthesis and translation initiation." @default.
- W1987036240 created "2016-06-24" @default.
- W1987036240 creator A5000236956 @default.
- W1987036240 creator A5005861452 @default.
- W1987036240 creator A5048378734 @default.
- W1987036240 creator A5073807348 @default.
- W1987036240 date "2001-05-01" @default.
- W1987036240 modified "2023-10-18" @default.
- W1987036240 title "Alcohol myopathy: impairment of protein synthesis and translation initiation" @default.
- W1987036240 cites W1529801894 @default.
- W1987036240 cites W153569057 @default.
- W1987036240 cites W1536727395 @default.
- W1987036240 cites W1587044218 @default.
- W1987036240 cites W184952481 @default.
- W1987036240 cites W1893438761 @default.
- W1987036240 cites W1943406382 @default.
- W1987036240 cites W1966942103 @default.
- W1987036240 cites W1977904428 @default.
- W1987036240 cites W1980836468 @default.
- W1987036240 cites W1989918610 @default.
- W1987036240 cites W1990934682 @default.
- W1987036240 cites W2005517873 @default.
- W1987036240 cites W2006818659 @default.
- W1987036240 cites W2009160352 @default.
- W1987036240 cites W2010973636 @default.
- W1987036240 cites W2013401012 @default.
- W1987036240 cites W2013537688 @default.
- W1987036240 cites W2013992903 @default.
- W1987036240 cites W2016115342 @default.
- W1987036240 cites W2018408638 @default.
- W1987036240 cites W2018466510 @default.
- W1987036240 cites W2021046633 @default.
- W1987036240 cites W2022131014 @default.
- W1987036240 cites W2033206378 @default.
- W1987036240 cites W2036704058 @default.
- W1987036240 cites W2045857887 @default.
- W1987036240 cites W2055252383 @default.
- W1987036240 cites W2057244264 @default.
- W1987036240 cites W2060672314 @default.
- W1987036240 cites W2061825971 @default.
- W1987036240 cites W2062801148 @default.
- W1987036240 cites W2065365493 @default.
- W1987036240 cites W2075069609 @default.
- W1987036240 cites W2076095948 @default.
- W1987036240 cites W2077263856 @default.
- W1987036240 cites W2080919878 @default.
- W1987036240 cites W2083155231 @default.
- W1987036240 cites W2086597762 @default.
- W1987036240 cites W2086977423 @default.
- W1987036240 cites W2088483259 @default.
- W1987036240 cites W2090034343 @default.
- W1987036240 cites W2095025167 @default.
- W1987036240 cites W2105496843 @default.
- W1987036240 cites W2114508665 @default.
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- W1987036240 cites W2122873325 @default.
- W1987036240 cites W2132670625 @default.
- W1987036240 cites W2136156195 @default.
- W1987036240 cites W2141026309 @default.
- W1987036240 cites W2148033841 @default.
- W1987036240 cites W2149849344 @default.
- W1987036240 cites W2150011315 @default.
- W1987036240 cites W2150364761 @default.
- W1987036240 cites W2154552941 @default.
- W1987036240 cites W2165543647 @default.
- W1987036240 cites W2169652737 @default.
- W1987036240 cites W2183111661 @default.
- W1987036240 cites W2183139538 @default.
- W1987036240 cites W2183412811 @default.
- W1987036240 cites W2183512122 @default.
- W1987036240 cites W2201156497 @default.
- W1987036240 cites W2256763537 @default.
- W1987036240 cites W2263439657 @default.
- W1987036240 cites W2275185758 @default.
- W1987036240 cites W2287589855 @default.
- W1987036240 cites W2287752887 @default.
- W1987036240 cites W2311575108 @default.
- W1987036240 cites W2312323687 @default.
- W1987036240 cites W2335570889 @default.
- W1987036240 cites W2415552691 @default.
- W1987036240 cites W2472216946 @default.
- W1987036240 cites W2966305709 @default.
- W1987036240 cites W4214761623 @default.
- W1987036240 cites W4231083821 @default.
- W1987036240 cites W4238412582 @default.
- W1987036240 cites W4251145504 @default.
- W1987036240 cites W48949035 @default.
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- W1987036240 doi "https://doi.org/10.1016/s1357-2725(00)00081-9" @default.
- W1987036240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11331201" @default.
- W1987036240 hasPublicationYear "2001" @default.
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