Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987039564> ?p ?o ?g. }
- W1987039564 endingPage "1648" @default.
- W1987039564 startingPage "1640" @default.
- W1987039564 abstract "• Osmium complexes are promising anticancer agents. • In vitro assays revealed antiproliferative activity in nanomolar concentrations. • New leads of osmium are well tolerated in vivo . • Diverse cellular modes of action were observed. • Compounds can be fine-tuned by selection of the ligands. Platinum compounds are one of the pillars of modern cancer chemotherapy. The apparent disadvantages of existing chemotherapeutics have led to the development of novel anticancer agents with alternative modes of action. Many complexes of the heavy metal osmium (Os) are potent growth inhibitors of human cancer cells and are active in vivo , often superior or comparable to cisplatin, as the benchmark metal-based anticancer agent, or clinically tested ruthenium (Ru) drug candidates. Depending on the choice of ligand system, osmium compounds exhibit diverse modes of action, including redox activation, DNA targeting or inhibition of protein kinases. In this review, we highlight recent advances in the development of osmium anticancer drug candidates and discuss their cellular mechanisms of action." @default.
- W1987039564 created "2016-06-24" @default.
- W1987039564 creator A5046842481 @default.
- W1987039564 creator A5086697134 @default.
- W1987039564 creator A5087288813 @default.
- W1987039564 date "2014-10-01" @default.
- W1987039564 modified "2023-10-16" @default.
- W1987039564 title "Development of anticancer agents: wizardry with osmium" @default.
- W1987039564 cites W1968283527 @default.
- W1987039564 cites W1985233650 @default.
- W1987039564 cites W1986209398 @default.
- W1987039564 cites W1989043508 @default.
- W1987039564 cites W1990932054 @default.
- W1987039564 cites W1992438153 @default.
- W1987039564 cites W1995488409 @default.
- W1987039564 cites W2002021050 @default.
- W1987039564 cites W2005723165 @default.
- W1987039564 cites W2007249785 @default.
- W1987039564 cites W2008002124 @default.
- W1987039564 cites W2009902696 @default.
- W1987039564 cites W2011855362 @default.
- W1987039564 cites W2017005182 @default.
- W1987039564 cites W2017356685 @default.
- W1987039564 cites W2018048442 @default.
- W1987039564 cites W2018410258 @default.
- W1987039564 cites W2021527389 @default.
- W1987039564 cites W2024146132 @default.
- W1987039564 cites W2027919238 @default.
- W1987039564 cites W2032728830 @default.
- W1987039564 cites W2039456073 @default.
- W1987039564 cites W2040357377 @default.
- W1987039564 cites W2040593990 @default.
- W1987039564 cites W2043465974 @default.
- W1987039564 cites W2055286653 @default.
- W1987039564 cites W2057842377 @default.
- W1987039564 cites W2059583857 @default.
- W1987039564 cites W2060001984 @default.
- W1987039564 cites W2063394834 @default.
- W1987039564 cites W2063401440 @default.
- W1987039564 cites W2064894863 @default.
- W1987039564 cites W2066916023 @default.
- W1987039564 cites W2069305928 @default.
- W1987039564 cites W2072527147 @default.
- W1987039564 cites W2072961231 @default.
- W1987039564 cites W2073608342 @default.
- W1987039564 cites W2075630515 @default.
- W1987039564 cites W2076168971 @default.
- W1987039564 cites W2077165807 @default.
- W1987039564 cites W2081307671 @default.
- W1987039564 cites W2088157280 @default.
- W1987039564 cites W2089169869 @default.
- W1987039564 cites W2089366029 @default.
- W1987039564 cites W2090064987 @default.
- W1987039564 cites W2094804988 @default.
- W1987039564 cites W2103188596 @default.
- W1987039564 cites W2109511270 @default.
- W1987039564 cites W2114818444 @default.
- W1987039564 cites W2116971674 @default.
- W1987039564 cites W2117541731 @default.
- W1987039564 cites W2119791735 @default.
- W1987039564 cites W2120250854 @default.
- W1987039564 cites W2130177169 @default.
- W1987039564 cites W2130237005 @default.
- W1987039564 cites W2141683790 @default.
- W1987039564 cites W2152085763 @default.
- W1987039564 cites W2154189654 @default.
- W1987039564 cites W2155688568 @default.
- W1987039564 cites W2156251664 @default.
- W1987039564 cites W2157825043 @default.
- W1987039564 cites W2159733863 @default.
- W1987039564 cites W2161490817 @default.
- W1987039564 cites W2330708657 @default.
- W1987039564 cites W2334594335 @default.
- W1987039564 cites W2570750060 @default.
- W1987039564 doi "https://doi.org/10.1016/j.drudis.2014.06.016" @default.
- W1987039564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24955838" @default.
- W1987039564 hasPublicationYear "2014" @default.
- W1987039564 type Work @default.
- W1987039564 sameAs 1987039564 @default.
- W1987039564 citedByCount "131" @default.
- W1987039564 countsByYear W19870395642014 @default.
- W1987039564 countsByYear W19870395642015 @default.
- W1987039564 countsByYear W19870395642016 @default.
- W1987039564 countsByYear W19870395642017 @default.
- W1987039564 countsByYear W19870395642018 @default.
- W1987039564 countsByYear W19870395642019 @default.
- W1987039564 countsByYear W19870395642020 @default.
- W1987039564 countsByYear W19870395642021 @default.
- W1987039564 countsByYear W19870395642022 @default.
- W1987039564 countsByYear W19870395642023 @default.
- W1987039564 crossrefType "journal-article" @default.
- W1987039564 hasAuthorship W1987039564A5046842481 @default.
- W1987039564 hasAuthorship W1987039564A5086697134 @default.
- W1987039564 hasAuthorship W1987039564A5087288813 @default.
- W1987039564 hasConcept C150903083 @default.
- W1987039564 hasConcept C161790260 @default.
- W1987039564 hasConcept C185592680 @default.
- W1987039564 hasConcept C202751555 @default.