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• W1987046943 abstract "Soluble class I human leukocyte antigens (sHLAs) have been detected in serum, sweat, lymphatic fluid, urine and cerebrospinal fluid. Their biological function has, however, remained a puzzle. The physiological concentration of sHLA varies more than tenfold depending on the phenotype of the individual, and is significantly upregulated in various diseases and during inflammation. This suggests that sHLAs might serve as a marker of pathological changes. Recent experiments have shown that, in vitro, sHLAs can modulate T-cell reactivity and induce cell-activated apoptosis, implicating sHLAs in the induction and maintenance of peripheral tolerance. Therefore, sHLAs have the therapeutic potential to induce tolerance to transplants." @default.
• W1987046943 created "2016-06-24" @default.
• W1987046943 creator A5051210233 @default.
• W1987046943 date "1998-03-01" @default.
• W1987046943 modified "2023-10-12" @default.
• W1987046943 title "Soluble HLA class I molecules: biological significance and clinical implications" @default.
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• W1987046943 doi "https://doi.org/10.1016/s1357-4310(97)01185-4" @default.
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