FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987049413> ?p ?o ?g. }

• W1987049413 endingPage "391" @default.
• W1987049413 startingPage "379" @default.
• W1987049413 abstract "CRAC channels are key calcium conduits in both physiological and pathological states. Understanding how these channels are controlled is important as this will not only provide insight into a novel signal transduction pathway coupling intracellular stores to the channels in the plasma membrane, but might also be of clinical relevance. Determining the molecular identity of the CRAC channels will certainly be a major step forward. Like all Ca2+-selective channels, CRAC channels lose their selectivity in divalent-free external solution to support large monovalent Na+ currents. This approach has provided new insight into channel permeation and selectivity, and identifies some interesting differences between CRAC channels and voltage-operated calcium channels (VOCCs). Studies in divalent-free solution are a double-edged sword, however. Electrophysiologists need to be wary because some of the conditions used to study ICRAC in divalent-free external solution, notably omission of Mg2+/Mg-ATP from the recording pipette solution, activates an additional current permeating through Mg2+-nucleotide-regulated metal ion current (MagNuM; TRPM7) channels. This channel underlies the large single-channel events that have been attributed to CRAC channels in the past and which have been used to as a tool to identify store-operated channels in native cells and recombinant expression systems. Are we any closer to identifying the elusive CRAC channel gene(s)? TRPV6 seemed a very attractive candidate, but one of the main arguments supporting it was a single-channel conductance in divalent-free solution similar to that for CRAC reported under conditions where MagNuM is active. We now know that the conductance of TRPV6 is ∼200-fold larger than that of CRAC in native tissue. Moreover, it is unclear if TRPV6 is store-operated. Further work on TRPV6, particularly whether its single-channel conductance is still high under conditions where it apparently forms multimers with endogenous store-operated channels, and whether it is activated by a variety of store depletion protocols, will be helpful in finally resolving this issue." @default.
• W1987049413 created "2016-06-24" @default.
• W1987049413 creator A5054059116 @default.
• W1987049413 creator A5078032635 @default.
• W1987049413 date "2002-11-01" @default.
• W1987049413 modified "2023-10-18" @default.
• W1987049413 title "Permeation through store-operated CRAC channels in divalent-free solution: potential problems and implications for putative CRAC channel genes" @default.
• W1987049413 cites W1536615603 @default.
• W1987049413 cites W1559892880 @default.
• W1987049413 cites W1573590097 @default.
• W1987049413 cites W1634886886 @default.
• W1987049413 cites W1942565546 @default.
• W1987049413 cites W1958244357 @default.
• W1987049413 cites W1966051958 @default.
• W1987049413 cites W1970288191 @default.
• W1987049413 cites W1971473766 @default.
• W1987049413 cites W1973217384 @default.
• W1987049413 cites W1980997572 @default.
• W1987049413 cites W1983856370 @default.
• W1987049413 cites W1990154764 @default.
• W1987049413 cites W1997808089 @default.
• W1987049413 cites W2006612346 @default.
• W1987049413 cites W2015480034 @default.
• W1987049413 cites W2020520033 @default.
• W1987049413 cites W2020910669 @default.
• W1987049413 cites W2022410485 @default.
• W1987049413 cites W2041690080 @default.
• W1987049413 cites W2042152248 @default.
• W1987049413 cites W2042832021 @default.
• W1987049413 cites W2046344499 @default.
• W1987049413 cites W2049332705 @default.
• W1987049413 cites W2051231103 @default.
• W1987049413 cites W2051766064 @default.
• W1987049413 cites W2052831035 @default.
• W1987049413 cites W2054736731 @default.
• W1987049413 cites W2061613974 @default.
• W1987049413 cites W2065256692 @default.
• W1987049413 cites W2065926642 @default.
• W1987049413 cites W2066696082 @default.
• W1987049413 cites W2069800034 @default.
• W1987049413 cites W2075105177 @default.
• W1987049413 cites W2076882136 @default.
• W1987049413 cites W2078012495 @default.
• W1987049413 cites W2081730365 @default.
• W1987049413 cites W2089599643 @default.
• W1987049413 cites W2093907469 @default.
• W1987049413 cites W2096437759 @default.
• W1987049413 cites W2097511933 @default.
• W1987049413 cites W2102097918 @default.
• W1987049413 cites W2109495864 @default.
• W1987049413 cites W2113431057 @default.
• W1987049413 cites W2115680989 @default.
• W1987049413 cites W2117850020 @default.
• W1987049413 cites W2117917356 @default.
• W1987049413 cites W2120038848 @default.
• W1987049413 cites W2125967951 @default.
• W1987049413 cites W2152630055 @default.
• W1987049413 cites W2156783552 @default.
• W1987049413 cites W2162970979 @default.
• W1987049413 cites W2169981344 @default.
• W1987049413 cites W2170319165 @default.
• W1987049413 cites W4244843546 @default.
• W1987049413 doi "https://doi.org/10.1016/s0143416002001914" @default.
• W1987049413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12543097" @default.
• W1987049413 hasPublicationYear "2002" @default.
• W1987049413 type Work @default.
• W1987049413 sameAs 1987049413 @default.
• W1987049413 citedByCount "40" @default.
• W1987049413 countsByYear W19870494132012 @default.
• W1987049413 countsByYear W19870494132013 @default.
• W1987049413 countsByYear W19870494132014 @default.
• W1987049413 countsByYear W19870494132016 @default.
• W1987049413 countsByYear W19870494132018 @default.
• W1987049413 countsByYear W19870494132019 @default.
• W1987049413 countsByYear W19870494132020 @default.
• W1987049413 countsByYear W19870494132021 @default.
• W1987049413 countsByYear W19870494132022 @default.
• W1987049413 crossrefType "journal-article" @default.
• W1987049413 hasAuthorship W1987049413A5054059116 @default.
• W1987049413 hasAuthorship W1987049413A5078032635 @default.
• W1987049413 hasConcept C12554922 @default.
• W1987049413 hasConcept C170493617 @default.
• W1987049413 hasConcept C178790620 @default.
• W1987049413 hasConcept C181911157 @default.
• W1987049413 hasConcept C185592680 @default.
• W1987049413 hasConcept C18699975 @default.
• W1987049413 hasConcept C2776610495 @default.
• W1987049413 hasConcept C50254741 @default.
• W1987049413 hasConcept C519063684 @default.
• W1987049413 hasConcept C55493867 @default.
• W1987049413 hasConcept C74884574 @default.
• W1987049413 hasConcept C86803240 @default.
• W1987049413 hasConceptScore W1987049413C12554922 @default.
• W1987049413 hasConceptScore W1987049413C170493617 @default.
• W1987049413 hasConceptScore W1987049413C178790620 @default.
• W1987049413 hasConceptScore W1987049413C181911157 @default.
• W1987049413 hasConceptScore W1987049413C185592680 @default.
• W1987049413 hasConceptScore W1987049413C18699975 @default.

• next