FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987051954> ?p ?o ?g. }

• W1987051954 endingPage "1228" @default.
• W1987051954 startingPage "1222" @default.
• W1987051954 abstract "We describe a novel model of insulin-deficient diabetes with a single copy of the gene encoding insulin 1 (Ins1) and no gene encoding insulin 2 (Ins2). We constructed five lines of mice: mice with two copies of Ins1 (NOD Ins1+/+,Ins2−/−), mice with a single copy of Ins1 (NOD Ins1+/−,Ins2−/−), mice with two copies of Ins2 (NOD Ins1−/−,Ins2+/+), mice with a single copy of Ins2 (NOD Ins1−/−,Ins2+/−) and NOD Ins1+/−,Ins2−/− mice with a transgene encoding B16:Ala proinsulin. By 10 weeks of age, all male NOD Ins1+/−,Ins2−/− mice were diabetic, whereas all female NOD Ins1+/−,Ins2−/− were not diabetic (p<0.0001). In contrast, neither male nor female NOD Ins1−/−,Ins2+/− with a single copy of Ins2 (rather than single copy of Ins1) developed early diabetes and no mice with two copies of either gene developed early diabetes. Islets of the diabetic male NOD Ins1+/−,Ins2−/− at this early age had no lymphocyte infiltration. Instead there was heterogeneous (between islet cells) weak staining for insulin. Although only male NOD Ins1+/−,Ins2−/− mice developed diabetes, both male and female NOD Ins1+/−,Ins2−/− mice had markedly decreased insulin content. In NOD Ins1+/+,Ins2−/−, there was also a significant decrease in insulin content, whereas NOD Ins1−/−,Ins2+/+ mice, and even NOD Ins1−/−,Ins2+/− mice, were normal. Male NOD Ins1+/−,Ins2−/− mice were completely rescued from diabetes by introduction of a transgene encoding proinsulin. On i.p. insulin tolerance testing, male mice had insulin resistance compared with female mice. These results suggest that Ins1 is a ‘defective gene’ relative to Ins2, and that the mouse lines created provide a novel model of sex-dimorphic insulin-deficient diabetes." @default.
• W1987051954 created "2016-06-24" @default.
• W1987051954 creator A5007390241 @default.
• W1987051954 creator A5008453103 @default.
• W1987051954 creator A5019794250 @default.
• W1987051954 creator A5023859731 @default.
• W1987051954 creator A5034223908 @default.
• W1987051954 creator A5038398583 @default.
• W1987051954 creator A5038406201 @default.
• W1987051954 creator A5061340857 @default.
• W1987051954 creator A5089570756 @default.
• W1987051954 date "2006-04-13" @default.
• W1987051954 modified "2023-09-29" @default.
• W1987051954 title "A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2" @default.
• W1987051954 cites W1994878054 @default.
• W1987051954 cites W2015941944 @default.
• W1987051954 cites W2026468137 @default.
• W1987051954 cites W2044731416 @default.
• W1987051954 cites W2049740824 @default.
• W1987051954 cites W2083738937 @default.
• W1987051954 cites W2084710830 @default.
• W1987051954 cites W2107144645 @default.
• W1987051954 cites W2111933310 @default.
• W1987051954 cites W2113799022 @default.
• W1987051954 cites W2117064653 @default.
• W1987051954 cites W2126278946 @default.
• W1987051954 cites W2132554143 @default.
• W1987051954 cites W2135514940 @default.
• W1987051954 cites W2154652388 @default.
• W1987051954 cites W2168996862 @default.
• W1987051954 cites W4242170242 @default.
• W1987051954 doi "https://doi.org/10.1007/s00125-006-0241-4" @default.
• W1987051954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16612590" @default.
• W1987051954 hasPublicationYear "2006" @default.
• W1987051954 type Work @default.
• W1987051954 sameAs 1987051954 @default.
• W1987051954 citedByCount "28" @default.
• W1987051954 countsByYear W19870519542012 @default.
• W1987051954 countsByYear W19870519542013 @default.
• W1987051954 countsByYear W19870519542014 @default.
• W1987051954 countsByYear W19870519542016 @default.
• W1987051954 countsByYear W19870519542018 @default.
• W1987051954 countsByYear W19870519542020 @default.
• W1987051954 countsByYear W19870519542021 @default.
• W1987051954 countsByYear W19870519542022 @default.
• W1987051954 countsByYear W19870519542023 @default.
• W1987051954 crossrefType "journal-article" @default.
• W1987051954 hasAuthorship W1987051954A5007390241 @default.
• W1987051954 hasAuthorship W1987051954A5008453103 @default.
• W1987051954 hasAuthorship W1987051954A5019794250 @default.
• W1987051954 hasAuthorship W1987051954A5023859731 @default.
• W1987051954 hasAuthorship W1987051954A5034223908 @default.
• W1987051954 hasAuthorship W1987051954A5038398583 @default.
• W1987051954 hasAuthorship W1987051954A5038406201 @default.
• W1987051954 hasAuthorship W1987051954A5061340857 @default.
• W1987051954 hasAuthorship W1987051954A5089570756 @default.
• W1987051954 hasBestOaLocation W19870519541 @default.
• W1987051954 hasConcept C126322002 @default.
• W1987051954 hasConcept C134018914 @default.
• W1987051954 hasConcept C2778013207 @default.
• W1987051954 hasConcept C2779306644 @default.
• W1987051954 hasConcept C555293320 @default.
• W1987051954 hasConcept C55851684 @default.
• W1987051954 hasConcept C71924100 @default.
• W1987051954 hasConcept C86803240 @default.
• W1987051954 hasConcept C90061646 @default.
• W1987051954 hasConceptScore W1987051954C126322002 @default.
• W1987051954 hasConceptScore W1987051954C134018914 @default.
• W1987051954 hasConceptScore W1987051954C2778013207 @default.
• W1987051954 hasConceptScore W1987051954C2779306644 @default.
• W1987051954 hasConceptScore W1987051954C555293320 @default.
• W1987051954 hasConceptScore W1987051954C55851684 @default.
• W1987051954 hasConceptScore W1987051954C71924100 @default.
• W1987051954 hasConceptScore W1987051954C86803240 @default.
• W1987051954 hasConceptScore W1987051954C90061646 @default.
• W1987051954 hasIssue "6" @default.
• W1987051954 hasLocation W19870519541 @default.
• W1987051954 hasLocation W19870519542 @default.
• W1987051954 hasOpenAccess W1987051954 @default.
• W1987051954 hasPrimaryLocation W19870519541 @default.
• W1987051954 hasRelatedWork W1997039251 @default.
• W1987051954 hasRelatedWork W2030768859 @default.
• W1987051954 hasRelatedWork W2039992937 @default.
• W1987051954 hasRelatedWork W2053067715 @default.
• W1987051954 hasRelatedWork W2064751303 @default.
• W1987051954 hasRelatedWork W2079112323 @default.
• W1987051954 hasRelatedWork W2090580735 @default.
• W1987051954 hasRelatedWork W2113905390 @default.
• W1987051954 hasRelatedWork W2119411112 @default.
• W1987051954 hasRelatedWork W2153742172 @default.
• W1987051954 hasVolume "49" @default.
• W1987051954 isParatext "false" @default.
• W1987051954 isRetracted "false" @default.
• W1987051954 magId "1987051954" @default.
• W1987051954 workType "article" @default.