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• W1987079765 abstract "In 1945, Earl Sutherland (1915-1974) [corrected] and associates began studies of the mechanism of hormone-induced glycogen breakdown in the liver. In 1956, their efforts culminated in the identification of cyclic AMP, an ancient molecule generated in many cell types in response to hormonal and other extracellular signals. Cyclic AMP, the original second messenger, transmits such signals through pathways that regulate a diversity of cellular functions and capabilities: metabolic processes such as lipolysis and glycogenolysis; hormone secretion; the permeability of ion channels; gene expression; cell proliferation and survival. Indeed, it can be argued that the discovery of cyclic AMP initiated the study of intracellular signaling pathways, a major focus of contemporary biomedical inquiry. This review presents relevant details of Sutherland's career; summarizes key contributions of his mentors, Carl and Gerti Cori, to the knowledge of glycogen metabolism (contributions that were the foundation for his own research); describes the experiments that led to his identification, isolation, and characterization of cyclic AMP; assesses the significance of his work; and considers some aspects of the impact of cyclic nucleotide research on clinical medicine." @default.
• W1987079765 created "2016-06-24" @default.
• W1987079765 creator A5062763193 @default.
• W1987079765 date "2012-01-01" @default.
• W1987079765 modified "2023-09-24" @default.
• W1987079765 title "Earl Sutherland (1915-1975) and the Discovery of Cyclic AMP" @default.
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• W1987079765 doi "https://doi.org/10.1353/pbm.2012.0017" @default.
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