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- W1987109404 abstract "Purpose: To improve the accuracy of lipid CH2/CH3 ratios determined by protonmagnetic resonancespectroscopy (MRS) by minimizing J‐coupling modulations of the CH3lipid peak. Method and Materials: Experiments were conducted in vivo on the tibial bone marrow lipids of four volunteers at 3 T. A regular PRESS (Point RESolved Spectroscopy)sequence was used to estimate the T2 (transverse relaxation) of the CH2protons by acquiring spectra at five echo times (TEs) and plotting the areas as a function of TE. The curve was fitted to the function Moexp(−TE/T2) where M0 is proportional to the CH2proton concentration. The CH3 response to a regular PRESS sequence is modulated due to J‐coupling interactions and does not decay monotonically. To determine Mo of the CH3protons a narrow‐bandwidth PRESS sequence was designed that rewinds the J‐coupling evolution of the CH3protons in the voxel of interest and spectra were acquired with the same five TEs. The CH2/CH3 ratio was calculated by dividing the CH2 Mo by that determined for CH3 and the result was multiplied by 1.5 to compensate for the different proton multiplicities. Results: The mean T2 of the CH2protons was estimated to be ≈ 88 ms. Applying the narrow‐bandwidth PRESS sequence minimized CH3 signal variations due to J‐coupling and resulted in a decay curve that could be described by a monoexponential T2 decay function. The mean T2 for the CH3protons was ≈ 133 ms. A mean ratio of 12:1 was calculated for the CH2:CH3 ratio of the tibial bone marrow lipids of all volunteers. Conclusion: The presented PRESS sequence enables the T2 of the CH3lipidprotons to be measured with more accuracy than would be determined by using short‐TEs thereby allowing a more accurate measure of the CH2/CH3lipid composition ratio to be determined." @default.
- W1987109404 created "2016-06-24" @default.
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- W1987109404 date "2010-06-01" @default.
- W1987109404 modified "2023-09-24" @default.
- W1987109404 title "TH-D-201C-10: Improved Quantification of the CH2/CH3 Ratio of Lipids: Illustration in Vivo on Tibial Bone Marrow at 3 T" @default.
- W1987109404 doi "https://doi.org/10.1118/1.3469558" @default.
- W1987109404 hasPublicationYear "2010" @default.
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