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- W1987111779 abstract "(1999) N Engl J Med 341, 468. Durham SR, Walker SM, Varga E-M, et al. . Long-term clinical efficacy of grass-pollen immunotherapy. . Aug 12; . : . –75 . [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In patients with grass pollen allergy successfully treated with immunotherapy for 3 to 4 years, does discontinuing maintenance immunotherapy result in increased symptoms and use of rescue medication? A 3 year randomised {allocation concealed*},† blinded (patients and investigators),* placebo controlled trial. A hospital allergy clinic in London, United Kingdom. 32 patients (59% men) who had a history of severe seasonal allergic rhinitis, poor control of symptoms, and a positive skin prick test to timothy grass pollen extract and who had completed 3 years of maintenance therapy with grass pollen injections. Exclusion criteria were history of other allergies or medical illnesses and chronic asthma; patients with mild asthma were included if their symptoms were controlled by inhaled sympathomimetic β2 adrenergic agonist bronchodilators. 15 matched, but not randomised, patients with allergic rhinitis who had never received immunotherapy were … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DDurham%26rft.auinit1%253DS.%2BR.%26rft.volume%253D341%26rft.issue%253D7%26rft.spage%253D468%26rft.epage%253D475%26rft.atitle%253DLong-Term%2BClinical%2BEfficacy%2Bof%2BGrass-Pollen%2BImmunotherapy%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJM199908123410702%26rft_id%253Dinfo%253Apmid%252F10441602%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJM199908123410702&link_type=DOI [3]: /lookup/external-ref?access_num=10441602&link_type=MED&atom=%2Febmed%2F5%2F2%2F46.atom [4]: /lookup/external-ref?access_num=000081962600002&link_type=ISI" @default.
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- W1987111779 date "2000-03-01" @default.
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- W1987111779 title "Grass pollen immunotherapy for 3 to 4 years was still effective 3 years after being discontinued" @default.
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- W1987111779 doi "https://doi.org/10.1136/ebm.5.2.46" @default.
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