FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987112069> ?p ?o ?g. }

• W1987112069 endingPage "255" @default.
• W1987112069 startingPage "247" @default.
• W1987112069 abstract "Abstract Several 1-aryl-4-(2-arylethyl)piperazine derivatives were synthesized and tested in-vitro for their binding affinity for 5-HT7 and 5-HT1A receptors. These compounds displayed 5-HT7 receptor affinity ranging between Ki = 474 nm and Ki = 8.2 nm, besides high affinity for the 5-HT1A receptor. Intrinsic activity of the most potent compounds was assessed. 4-[2-(3-Methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine (16) and 1-(1,2-benzisoxazol-3-yl)-4-[2-(3-methoxyphenyl)ethyl]piperazine (20) (Ki = 24.5 and 8.2 nm, respectively) behaved as partial agonist and full agonist, respectively, when tested for 5-HT7 receptor-mediated relaxation of substance P-induced guinea-pig ileum contraction." @default.
• W1987112069 created "2016-06-24" @default.
• W1987112069 creator A5010068826 @default.
• W1987112069 creator A5021058541 @default.
• W1987112069 creator A5029727582 @default.
• W1987112069 creator A5031583097 @default.
• W1987112069 creator A5044614573 @default.
• W1987112069 creator A5047303234 @default.
• W1987112069 creator A5089166509 @default.
• W1987112069 date "2004-02-01" @default.
• W1987112069 modified "2023-10-16" @default.
• W1987112069 title "Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors" @default.
• W1987112069 cites W1565257873 @default.
• W1987112069 cites W1966140567 @default.
• W1987112069 cites W1968099960 @default.
• W1987112069 cites W2008886079 @default.
• W1987112069 cites W2014001501 @default.
• W1987112069 cites W2019322821 @default.
• W1987112069 cites W2021374111 @default.
• W1987112069 cites W2022836587 @default.
• W1987112069 cites W2028377617 @default.
• W1987112069 cites W2032660872 @default.
• W1987112069 cites W2038003808 @default.
• W1987112069 cites W2040667380 @default.
• W1987112069 cites W2040903359 @default.
• W1987112069 cites W2042535216 @default.
• W1987112069 cites W2048868418 @default.
• W1987112069 cites W2053195651 @default.
• W1987112069 cites W2057859837 @default.
• W1987112069 cites W2059057526 @default.
• W1987112069 cites W2065333679 @default.
• W1987112069 cites W2069067710 @default.
• W1987112069 cites W2074631079 @default.
• W1987112069 cites W2078124639 @default.
• W1987112069 cites W2078552770 @default.
• W1987112069 cites W2080461836 @default.
• W1987112069 cites W2095054997 @default.
• W1987112069 cites W2102438497 @default.
• W1987112069 cites W2121561049 @default.
• W1987112069 cites W2121879218 @default.
• W1987112069 cites W2143787546 @default.
• W1987112069 cites W2148975835 @default.
• W1987112069 cites W2149918176 @default.
• W1987112069 cites W2150882375 @default.
• W1987112069 cites W2154865824 @default.
• W1987112069 cites W2180248420 @default.
• W1987112069 cites W2316087042 @default.
• W1987112069 cites W2517656431 @default.
• W1987112069 cites W331245965 @default.
• W1987112069 cites W4250669383 @default.
• W1987112069 doi "https://doi.org/10.1211/0022357022575" @default.
• W1987112069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15005884" @default.
• W1987112069 hasPublicationYear "2004" @default.
• W1987112069 type Work @default.
• W1987112069 sameAs 1987112069 @default.
• W1987112069 citedByCount "28" @default.
• W1987112069 countsByYear W19871120692012 @default.
• W1987112069 countsByYear W19871120692013 @default.
• W1987112069 countsByYear W19871120692014 @default.
• W1987112069 countsByYear W19871120692015 @default.
• W1987112069 countsByYear W19871120692017 @default.
• W1987112069 countsByYear W19871120692018 @default.
• W1987112069 crossrefType "journal-article" @default.
• W1987112069 hasAuthorship W1987112069A5010068826 @default.
• W1987112069 hasAuthorship W1987112069A5021058541 @default.
• W1987112069 hasAuthorship W1987112069A5029727582 @default.
• W1987112069 hasAuthorship W1987112069A5031583097 @default.
• W1987112069 hasAuthorship W1987112069A5044614573 @default.
• W1987112069 hasAuthorship W1987112069A5047303234 @default.
• W1987112069 hasAuthorship W1987112069A5089166509 @default.
• W1987112069 hasConcept C134018914 @default.
• W1987112069 hasConcept C170493617 @default.
• W1987112069 hasConcept C178790620 @default.
• W1987112069 hasConcept C185592680 @default.
• W1987112069 hasConcept C195454581 @default.
• W1987112069 hasConcept C202751555 @default.
• W1987112069 hasConcept C2775864247 @default.
• W1987112069 hasConcept C2776201271 @default.
• W1987112069 hasConcept C2778815084 @default.
• W1987112069 hasConcept C2778938600 @default.
• W1987112069 hasConcept C53910766 @default.
• W1987112069 hasConcept C55493867 @default.
• W1987112069 hasConcept C58732023 @default.
• W1987112069 hasConcept C71240020 @default.
• W1987112069 hasConcept C86803240 @default.
• W1987112069 hasConceptScore W1987112069C134018914 @default.
• W1987112069 hasConceptScore W1987112069C170493617 @default.
• W1987112069 hasConceptScore W1987112069C178790620 @default.
• W1987112069 hasConceptScore W1987112069C185592680 @default.
• W1987112069 hasConceptScore W1987112069C195454581 @default.
• W1987112069 hasConceptScore W1987112069C202751555 @default.
• W1987112069 hasConceptScore W1987112069C2775864247 @default.
• W1987112069 hasConceptScore W1987112069C2776201271 @default.
• W1987112069 hasConceptScore W1987112069C2778815084 @default.
• W1987112069 hasConceptScore W1987112069C2778938600 @default.
• W1987112069 hasConceptScore W1987112069C53910766 @default.
• W1987112069 hasConceptScore W1987112069C55493867 @default.
• W1987112069 hasConceptScore W1987112069C58732023 @default.

• next