FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987114596> ?p ?o ?g. }

• W1987114596 endingPage "10" @default.
• W1987114596 startingPage "10" @default.
• W1987114596 abstract "Background: The distinction of lung adenocarcinoma (ADC) from squamous cell carcinoma (SCC) has important therapeutic implications. Napsin A is a recently developed marker, which has shown high specificity for lung tissue in the surgical pathology specimens. In this study, we have evaluated whether the use of a panel of novel multiplex cocktails of TTF-1 + Napsin A and p63 + CK5 for dual color immunostaining will improve the diagnostic accuracy of lung adenocarcinoma and squamous cell carcinoma in fine needle aspiration (FNA) specimens, usually with relatively scant microfragments of diagnostic material. Materials and Methods: Formalin-fixed, paraffin-embedded, adequately cellular FNA cell blocks with a confirmed diagnosis of either ADC (n = 22), SCC (n = 20) or poorly differentiated carcinoma (PDC; n = 7), from a total of 49 consecutive cases, were studied. All these cases had subsequently confirmed diagnosis in biopsies or resection specimens. The sections were immunostained with two color methods of TTF-1 + Napsin A and p63 + CK5 multiplex cocktails. The presence of one or more unequivocal individual tumor cells with convincing brown nuclear TTF-1 and red cytoplasmic Napsin A staining, and cells with brown nuclear p63 and membranous / cytoplasmic CK5 staining were interpreted as ‘positive’. Results: All 20 FNA cell blocks from SCC cases were positive for dual stain p63 + CK5 and negative for dual stain TTF-1 + Napsin A. The sensitivity and specificity of the dual immunoexpressions of p63 + CK5 for SCC of lung FNAs were both 100%. All 22 ADC cases were positive with dual stain of TTF-1 + Napsin A and negative for dual stain of p63 + CK5. On follow-up of the surgical pathology specimens, 22 cases were confirmed as ADC. The sensitivity of the dual immunoexpression of TTF-1 + Napsin A for ADC of lung FNAs was 100% and the specificity was also 100%. Of the seven PDC cases, five cases that were positive for dual stain p63 + CK5 and negative for dual stain TTF-1 + Napsin A could be categorized as SCC. Two of the seven (2 / 7) PDC cases were positive for dual stain TTF-1 + Napsin A and negative for dual stain p63 + CK5, consistent with ADC. Conclusions: Simultaneous coordinate or individual immunostaining for Napsin A / TTF-1 in ADC and p63 / CK5 in SCC demonstrated high sensitivity and specificity. The panel with multiplex Napsin A / TTF-1 and p63 / CK5 dual color immunostains could specifically subcategorize PDC into ADC and SCC in lung FNA specimens. Multiplex dual color Napsin A / TTF-1 and p63 / CK5 immunostaining is especially recommended for evaluation of FNA specimens with relatively scant cellularity." @default.
• W1987114596 created "2016-06-24" @default.
• W1987114596 creator A5002704326 @default.
• W1987114596 creator A5003161591 @default.
• W1987114596 creator A5003715247 @default.
• W1987114596 creator A5015536008 @default.
• W1987114596 creator A5038389569 @default.
• W1987114596 creator A5050907029 @default.
• W1987114596 creator A5063670528 @default.
• W1987114596 creator A5079830067 @default.
• W1987114596 creator A5089718956 @default.
• W1987114596 creator A5090483140 @default.
• W1987114596 date "2012-03-31" @default.
• W1987114596 modified "2023-10-16" @default.
• W1987114596 title "Dual color multiplex TTF-1 + Napsin A and p63 + CK5 immunostaining for subcategorizing of poorly differentiated pulmonary non-small carcinomas into adenocarcinoma and squamous cell carcinoma in fine needle aspiration specimens" @default.
• W1987114596 cites W1496136993 @default.
• W1987114596 cites W1969376370 @default.
• W1987114596 cites W1973414121 @default.
• W1987114596 cites W1999889434 @default.
• W1987114596 cites W2014902682 @default.
• W1987114596 cites W2047989123 @default.
• W1987114596 cites W2056320979 @default.
• W1987114596 cites W2066135588 @default.
• W1987114596 cites W2069422280 @default.
• W1987114596 cites W2074657801 @default.
• W1987114596 cites W2078560062 @default.
• W1987114596 cites W2084845277 @default.
• W1987114596 cites W2101692676 @default.
• W1987114596 cites W2104495908 @default.
• W1987114596 cites W2109848442 @default.
• W1987114596 cites W2125212831 @default.
• W1987114596 cites W2125558775 @default.
• W1987114596 cites W2141293478 @default.
• W1987114596 cites W2233351309 @default.
• W1987114596 cites W2317017975 @default.
• W1987114596 cites W4242948142 @default.
• W1987114596 doi "https://doi.org/10.4103/1742-6413.94570" @default.
• W1987114596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3347720" @default.
• W1987114596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22582081" @default.
• W1987114596 hasPublicationYear "2012" @default.
• W1987114596 type Work @default.
• W1987114596 sameAs 1987114596 @default.
• W1987114596 citedByCount "23" @default.
• W1987114596 countsByYear W19871145962012 @default.
• W1987114596 countsByYear W19871145962013 @default.
• W1987114596 countsByYear W19871145962014 @default.
• W1987114596 countsByYear W19871145962015 @default.
• W1987114596 countsByYear W19871145962016 @default.
• W1987114596 countsByYear W19871145962018 @default.
• W1987114596 countsByYear W19871145962019 @default.
• W1987114596 countsByYear W19871145962020 @default.
• W1987114596 countsByYear W19871145962021 @default.
• W1987114596 countsByYear W19871145962022 @default.
• W1987114596 crossrefType "journal-article" @default.
• W1987114596 hasAuthorship W1987114596A5002704326 @default.
• W1987114596 hasAuthorship W1987114596A5003161591 @default.
• W1987114596 hasAuthorship W1987114596A5003715247 @default.
• W1987114596 hasAuthorship W1987114596A5015536008 @default.
• W1987114596 hasAuthorship W1987114596A5038389569 @default.
• W1987114596 hasAuthorship W1987114596A5050907029 @default.
• W1987114596 hasAuthorship W1987114596A5063670528 @default.
• W1987114596 hasAuthorship W1987114596A5079830067 @default.
• W1987114596 hasAuthorship W1987114596A5089718956 @default.
• W1987114596 hasAuthorship W1987114596A5090483140 @default.
• W1987114596 hasBestOaLocation W19871145961 @default.
• W1987114596 hasConcept C121608353 @default.
• W1987114596 hasConcept C126322002 @default.
• W1987114596 hasConcept C142724271 @default.
• W1987114596 hasConcept C204232928 @default.
• W1987114596 hasConcept C2775934546 @default.
• W1987114596 hasConcept C2776170712 @default.
• W1987114596 hasConcept C2777546739 @default.
• W1987114596 hasConcept C2781182431 @default.
• W1987114596 hasConcept C2781188995 @default.
• W1987114596 hasConcept C2781294515 @default.
• W1987114596 hasConcept C4224716 @default.
• W1987114596 hasConcept C60644358 @default.
• W1987114596 hasConcept C71924100 @default.
• W1987114596 hasConcept C74864618 @default.
• W1987114596 hasConcept C86803240 @default.
• W1987114596 hasConceptScore W1987114596C121608353 @default.
• W1987114596 hasConceptScore W1987114596C126322002 @default.
• W1987114596 hasConceptScore W1987114596C142724271 @default.
• W1987114596 hasConceptScore W1987114596C204232928 @default.
• W1987114596 hasConceptScore W1987114596C2775934546 @default.
• W1987114596 hasConceptScore W1987114596C2776170712 @default.
• W1987114596 hasConceptScore W1987114596C2777546739 @default.
• W1987114596 hasConceptScore W1987114596C2781182431 @default.
• W1987114596 hasConceptScore W1987114596C2781188995 @default.
• W1987114596 hasConceptScore W1987114596C2781294515 @default.
• W1987114596 hasConceptScore W1987114596C4224716 @default.
• W1987114596 hasConceptScore W1987114596C60644358 @default.
• W1987114596 hasConceptScore W1987114596C71924100 @default.
• W1987114596 hasConceptScore W1987114596C74864618 @default.
• W1987114596 hasConceptScore W1987114596C86803240 @default.
• W1987114596 hasLocation W19871145961 @default.
• W1987114596 hasLocation W19871145962 @default.
• W1987114596 hasLocation W19871145963 @default.

• next