FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987114834> ?p ?o ?g. }

• W1987114834 endingPage "16" @default.
• W1987114834 startingPage "9" @default.
• W1987114834 abstract "Galectin-3 expression in rat intervertebral disc at different stages in postnatal life is evaluated.To determine if galectin-3 expression is confined to cells of the nucleus pulposus in the postnatal rat intervertebral disc.During embryonic development, the anulus fibrosus is derived from the sclerotome, whereas the nucleus pulposus is notochordal. Many authorities opine that in the postnatal disc, notochordal cells play a central role in controlling the development of degenerative disc disease. Surprisingly, unequivocal evidence supporting the existence of notochordal cells in the nucleus pulposus in postnatal life has yet to be demonstrated. Since the expression of galectin-3 is commonly used to identify notochordal cells, we evaluated its expression in tissues of the rat disc and in cultured cells.Galectin-3 expression was studied in the nucleus pulposus and anulus fibrosus tissue of rat discs (2 days, 9 weeks, and 10 months old), and cultured cells using different biochemical and molecular biology methods. Rat sternal cartilage and cultured sternal chondrocytes were used as controls.Immunohistochemical studies indicated that galectin-3 was present in the nucleus pulposus and anulus fibrosus. In both discal tissues and cultured cells, studies confirmed that there was a robust expression of galectin-3 messenger ribonucleic acid and protein. Protein expression patterns were similar in neonatal, young, and mature rats. There was also evidence of intracellular and membrane expression of galectin-3 in the cultured disc cells. Finally, significant levels of galectin-3 were evident in rat sternal cartilage and cultured sternal chondrocytes.Results of the study indicate that galectin-3 is expressed in the neonatal, young, and mature rat disc, and its expression is not restricted to the cells of the nucleus pulposus. Because of its ubiquitous expression, this protein cannot be used as a marker of notochordal cells in the postnatal rat disc." @default.
• W1987114834 created "2016-06-24" @default.
• W1987114834 creator A5003836277 @default.
• W1987114834 creator A5011224388 @default.
• W1987114834 creator A5011490169 @default.
• W1987114834 creator A5012718663 @default.
• W1987114834 creator A5019521528 @default.
• W1987114834 creator A5030209609 @default.
• W1987114834 creator A5046825258 @default.
• W1987114834 date "2007-01-01" @default.
• W1987114834 modified "2023-10-01" @default.
• W1987114834 title "Galectin-3 Expression in the Intervertebral Disc: A Useful Marker of the Notochord Phenotype?" @default.
• W1987114834 cites W106776827 @default.
• W1987114834 cites W1965024650 @default.
• W1987114834 cites W1966814089 @default.
• W1987114834 cites W1970680780 @default.
• W1987114834 cites W1980434442 @default.
• W1987114834 cites W1989388378 @default.
• W1987114834 cites W1995909770 @default.
• W1987114834 cites W2000898869 @default.
• W1987114834 cites W2011467554 @default.
• W1987114834 cites W2027990128 @default.
• W1987114834 cites W2038461954 @default.
• W1987114834 cites W2047276414 @default.
• W1987114834 cites W2057259147 @default.
• W1987114834 cites W2060490044 @default.
• W1987114834 cites W2061460842 @default.
• W1987114834 cites W2065011645 @default.
• W1987114834 cites W2067939012 @default.
• W1987114834 cites W2082421146 @default.
• W1987114834 cites W2140684466 @default.
• W1987114834 cites W2141848254 @default.
• W1987114834 cites W2163528858 @default.
• W1987114834 cites W2244595585 @default.
• W1987114834 cites W2334675461 @default.
• W1987114834 cites W4231870480 @default.
• W1987114834 doi "https://doi.org/10.1097/01.brs.0000250302.74574.98" @default.
• W1987114834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17202886" @default.
• W1987114834 hasPublicationYear "2007" @default.
• W1987114834 type Work @default.
• W1987114834 sameAs 1987114834 @default.
• W1987114834 citedByCount "25" @default.
• W1987114834 countsByYear W19871148342012 @default.
• W1987114834 countsByYear W19871148342013 @default.
• W1987114834 countsByYear W19871148342014 @default.
• W1987114834 countsByYear W19871148342016 @default.
• W1987114834 countsByYear W19871148342017 @default.
• W1987114834 countsByYear W19871148342018 @default.
• W1987114834 countsByYear W19871148342019 @default.
• W1987114834 countsByYear W19871148342021 @default.
• W1987114834 countsByYear W19871148342023 @default.
• W1987114834 crossrefType "journal-article" @default.
• W1987114834 hasAuthorship W1987114834A5003836277 @default.
• W1987114834 hasAuthorship W1987114834A5011224388 @default.
• W1987114834 hasAuthorship W1987114834A5011490169 @default.
• W1987114834 hasAuthorship W1987114834A5012718663 @default.
• W1987114834 hasAuthorship W1987114834A5019521528 @default.
• W1987114834 hasAuthorship W1987114834A5030209609 @default.
• W1987114834 hasAuthorship W1987114834A5046825258 @default.
• W1987114834 hasConcept C105702510 @default.
• W1987114834 hasConcept C142724271 @default.
• W1987114834 hasConcept C189165786 @default.
• W1987114834 hasConcept C196843134 @default.
• W1987114834 hasConcept C204232928 @default.
• W1987114834 hasConcept C2776133846 @default.
• W1987114834 hasConcept C2777755357 @default.
• W1987114834 hasConcept C2778051963 @default.
• W1987114834 hasConcept C2780550940 @default.
• W1987114834 hasConcept C2780723820 @default.
• W1987114834 hasConcept C44575665 @default.
• W1987114834 hasConcept C71924100 @default.
• W1987114834 hasConcept C86803240 @default.
• W1987114834 hasConcept C87073359 @default.
• W1987114834 hasConcept C95444343 @default.
• W1987114834 hasConceptScore W1987114834C105702510 @default.
• W1987114834 hasConceptScore W1987114834C142724271 @default.
• W1987114834 hasConceptScore W1987114834C189165786 @default.
• W1987114834 hasConceptScore W1987114834C196843134 @default.
• W1987114834 hasConceptScore W1987114834C204232928 @default.
• W1987114834 hasConceptScore W1987114834C2776133846 @default.
• W1987114834 hasConceptScore W1987114834C2777755357 @default.
• W1987114834 hasConceptScore W1987114834C2778051963 @default.
• W1987114834 hasConceptScore W1987114834C2780550940 @default.
• W1987114834 hasConceptScore W1987114834C2780723820 @default.
• W1987114834 hasConceptScore W1987114834C44575665 @default.
• W1987114834 hasConceptScore W1987114834C71924100 @default.
• W1987114834 hasConceptScore W1987114834C86803240 @default.
• W1987114834 hasConceptScore W1987114834C87073359 @default.
• W1987114834 hasConceptScore W1987114834C95444343 @default.
• W1987114834 hasIssue "1" @default.
• W1987114834 hasLocation W19871148341 @default.
• W1987114834 hasLocation W19871148342 @default.
• W1987114834 hasOpenAccess W1987114834 @default.
• W1987114834 hasPrimaryLocation W19871148341 @default.
• W1987114834 hasRelatedWork W1904446927 @default.
• W1987114834 hasRelatedWork W1964559562 @default.
• W1987114834 hasRelatedWork W1984414065 @default.
• W1987114834 hasRelatedWork W2064356629 @default.

• next