FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987118766> ?p ?o ?g. }

• W1987118766 endingPage "1102" @default.
• W1987118766 startingPage "1091" @default.
• W1987118766 abstract "Large conductance calcium-activated potassium (BK(Ca)) channels are membrane proteins contributing to electrical propagation through neurons. Calcitonin gene-related peptide (CGRP) is a neuropeptide found in the trigeminovascular system (TGVS). Both BK(Ca) channels and CGRP are involved in migraine pathophysiology. Here we study the expression and localization of BK(Ca) channels and CGRP in the rat trigeminal ganglion (TG) and the trigeminal nucleus caudalis (TNC) as these structures are involved in migraine pain. Also the effect of the BK(Ca) channel blocker iberiotoxin and the BK(Ca) channel opener NS11021 on CGRP release from isolated TG and TNC was investigated. By RT-PCR, BK(Ca) channel mRNA was detected in the TG and the TNC. A significant difference in BK(Ca) channel mRNA transcript levels were found using qPCR between the TNC as compared to the TG. The BK(Ca) channel protein was more expressed in the TNC as compared to the TG shown by western blotting. Immunohistochemistry identified BK(Ca) channels in the nerve cell bodies of the TG and the TNC. The beta2- and beta4-subunit proteins were found in the TG and the TNC. They were both more expressed in the TNC as compared to TG shown by western blotting. In isolated TNC, the BK(Ca) channel blocker iberiotoxin induced a concentration-dependent release of CGRP that was attenuated by the BK(Ca) channel opener NS11021. No effect on basal CGRP release was found by NS11021 in isolated TG or TNC or by iberiotoxin in TG. In conclusion, we found both BK(Ca) channel mRNA and protein expression in the TG and the TNC. The BK(Ca) channel protein and the modulatory beta2- and beta4-subunt proteins were more expressed in the TNC than in the TG. Iberiotoxin induced an increase in CGRP release from the TNC that was attenuated by NS11021. Thus, BK(Ca) channels might have a role in trigeminovascular pain transmission." @default.
• W1987118766 created "2016-06-24" @default.
• W1987118766 creator A5020891381 @default.
• W1987118766 creator A5024808838 @default.
• W1987118766 creator A5048426489 @default.
• W1987118766 creator A5052906959 @default.
• W1987118766 creator A5074300840 @default.
• W1987118766 creator A5081491299 @default.
• W1987118766 creator A5089119114 @default.
• W1987118766 date "2010-06-01" @default.
• W1987118766 modified "2023-10-14" @default.
• W1987118766 title "Localization of large conductance calcium-activated potassium channels and their effect on calcitonin gene-related peptide release in the rat trigemino–neuronal pathway" @default.
• W1987118766 cites W1560867685 @default.
• W1987118766 cites W1602374960 @default.
• W1987118766 cites W1603155066 @default.
• W1987118766 cites W1626920804 @default.
• W1987118766 cites W1667367966 @default.
• W1987118766 cites W1849480202 @default.
• W1987118766 cites W1978540371 @default.
• W1987118766 cites W1982394915 @default.
• W1987118766 cites W1989245704 @default.
• W1987118766 cites W1993563590 @default.
• W1987118766 cites W1997347283 @default.
• W1987118766 cites W1998287765 @default.
• W1987118766 cites W2004800687 @default.
• W1987118766 cites W2008687717 @default.
• W1987118766 cites W2009688249 @default.
• W1987118766 cites W2014264924 @default.
• W1987118766 cites W2016763372 @default.
• W1987118766 cites W2020043315 @default.
• W1987118766 cites W2021958245 @default.
• W1987118766 cites W2022295508 @default.
• W1987118766 cites W2022558665 @default.
• W1987118766 cites W2023130165 @default.
• W1987118766 cites W2028447836 @default.
• W1987118766 cites W2041847544 @default.
• W1987118766 cites W2045375281 @default.
• W1987118766 cites W2046951924 @default.
• W1987118766 cites W2048132386 @default.
• W1987118766 cites W2049324620 @default.
• W1987118766 cites W2058991699 @default.
• W1987118766 cites W2059418277 @default.
• W1987118766 cites W2063845237 @default.
• W1987118766 cites W2070776478 @default.
• W1987118766 cites W2083855520 @default.
• W1987118766 cites W2084303869 @default.
• W1987118766 cites W2084903350 @default.
• W1987118766 cites W2090033907 @default.
• W1987118766 cites W2091685020 @default.
• W1987118766 cites W2093404236 @default.
• W1987118766 cites W2098988727 @default.
• W1987118766 cites W2104141601 @default.
• W1987118766 cites W2109713300 @default.
• W1987118766 cites W2126219184 @default.
• W1987118766 cites W2128321748 @default.
• W1987118766 cites W2134747766 @default.
• W1987118766 cites W2141832664 @default.
• W1987118766 cites W2142131601 @default.
• W1987118766 cites W2148858803 @default.
• W1987118766 cites W2153258491 @default.
• W1987118766 cites W2159557413 @default.
• W1987118766 cites W2167865466 @default.
• W1987118766 cites W2235505912 @default.
• W1987118766 cites W4312861633 @default.
• W1987118766 cites W61928364 @default.
• W1987118766 doi "https://doi.org/10.1016/j.neuroscience.2010.02.063" @default.
• W1987118766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20211697" @default.
• W1987118766 hasPublicationYear "2010" @default.
• W1987118766 type Work @default.
• W1987118766 sameAs 1987118766 @default.
• W1987118766 citedByCount "28" @default.
• W1987118766 countsByYear W19871187662012 @default.
• W1987118766 countsByYear W19871187662013 @default.
• W1987118766 countsByYear W19871187662014 @default.
• W1987118766 countsByYear W19871187662015 @default.
• W1987118766 countsByYear W19871187662017 @default.
• W1987118766 countsByYear W19871187662019 @default.
• W1987118766 countsByYear W19871187662020 @default.
• W1987118766 countsByYear W19871187662021 @default.
• W1987118766 countsByYear W19871187662022 @default.
• W1987118766 countsByYear W19871187662023 @default.
• W1987118766 crossrefType "journal-article" @default.
• W1987118766 hasAuthorship W1987118766A5020891381 @default.
• W1987118766 hasAuthorship W1987118766A5024808838 @default.
• W1987118766 hasAuthorship W1987118766A5048426489 @default.
• W1987118766 hasAuthorship W1987118766A5052906959 @default.
• W1987118766 hasAuthorship W1987118766A5074300840 @default.
• W1987118766 hasAuthorship W1987118766A5081491299 @default.
• W1987118766 hasAuthorship W1987118766A5089119114 @default.
• W1987118766 hasConcept C118303440 @default.
• W1987118766 hasConcept C126322002 @default.
• W1987118766 hasConcept C134018914 @default.
• W1987118766 hasConcept C153461711 @default.
• W1987118766 hasConcept C163170386 @default.
• W1987118766 hasConcept C169760540 @default.
• W1987118766 hasConcept C170493617 @default.
• W1987118766 hasConcept C185592680 @default.
• W1987118766 hasConcept C2776352249 @default.

• next