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- W1987126916 abstract "Oligodendrocyte (OL) death occurs in many disorders of the CNS, including multiple sclerosis and brain trauma. Factors reported to induce OL death include deprivation of growth factors, elevation of cytokines, oxidative stress, and glutamate excitotoxicity. Because astrocytes produce a large amount of growth factors and antioxidants and are a major source of glutamate uptake, we tested the hypothesis that astrocytes may have a protective role for OL survival. We report that when OLs from the adult mouse brain were initiated into tissue culture, DNA fragmentation and chromatin condensation resulted, indicative of apoptosis. OL death was significantly reduced in coculture with astrocytes, but not with fibroblasts, which provided a similar monolayer of cells as astrocytes. The protection of OL demise by astrocytes was not reproduced by its conditioned medium and was not accounted for by several neurotrophic factors. In contrast, interference with the α6 integrin subunit, but not the α1, α2, α3, α4, α5, or αv integrin chains, negated astrocyte protection of OLs. Furthermore, a function-blocking antibody to α6β1 integrin reduced the ability of astrocytes to promote OL survival. The extracellular matrix ligand for α6β1 is laminin, which is expressed by astrocytes. Significantly, neutralizing antibodies to laminin-2 and laminin-5 inhibited the astrocyte mediation of OL survival. These results implicate astrocytes in promoting OL survival through a mechanism involving the interaction of α6β1 integrin on OLs with laminin on astrocytes. Enhancing this interaction may provide for OL survival in neurological injury. GLIA 36:281–294, 2001. © 2001 Wiley-Liss, Inc." @default.
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- W1987126916 date "2001-01-01" @default.
- W1987126916 modified "2023-10-15" @default.
- W1987126916 title "Astrocytes attenuate oligodendrocyte death in vitro through an ?6 integrin-laminin-dependent mechanism" @default.
- W1987126916 cites W1495400592 @default.
- W1987126916 cites W1529396499 @default.
- W1987126916 cites W1568752613 @default.
- W1987126916 cites W1572253423 @default.
- W1987126916 cites W1837155564 @default.
- W1987126916 cites W1847979911 @default.
- W1987126916 cites W1866034006 @default.
- W1987126916 cites W1921871464 @default.
- W1987126916 cites W1964928356 @default.
- W1987126916 cites W1966747439 @default.
- W1987126916 cites W1970483666 @default.
- W1987126916 cites W1977015296 @default.
- W1987126916 cites W1978248988 @default.
- W1987126916 cites W1982592829 @default.
- W1987126916 cites W1982784171 @default.
- W1987126916 cites W1985193039 @default.
- W1987126916 cites W1987192817 @default.
- W1987126916 cites W1990306722 @default.
- W1987126916 cites W1993216157 @default.
- W1987126916 cites W1997619705 @default.
- W1987126916 cites W1998451067 @default.
- W1987126916 cites W2001493281 @default.
- W1987126916 cites W2002127663 @default.
- W1987126916 cites W2004219852 @default.
- W1987126916 cites W2005223686 @default.
- W1987126916 cites W2015284998 @default.
- W1987126916 cites W2016831735 @default.
- W1987126916 cites W2017847893 @default.
- W1987126916 cites W2018097963 @default.
- W1987126916 cites W2018222725 @default.
- W1987126916 cites W2023039354 @default.
- W1987126916 cites W2024059382 @default.
- W1987126916 cites W2025361420 @default.
- W1987126916 cites W2026497353 @default.
- W1987126916 cites W2026530738 @default.
- W1987126916 cites W2027126363 @default.
- W1987126916 cites W2029385473 @default.
- W1987126916 cites W2032207419 @default.
- W1987126916 cites W2032684109 @default.
- W1987126916 cites W2033801757 @default.
- W1987126916 cites W2036387937 @default.
- W1987126916 cites W2036567890 @default.
- W1987126916 cites W2038726437 @default.
- W1987126916 cites W2039035657 @default.
- W1987126916 cites W2039300085 @default.
- W1987126916 cites W2040147172 @default.
- W1987126916 cites W2041085914 @default.
- W1987126916 cites W2046204149 @default.
- W1987126916 cites W2051217333 @default.
- W1987126916 cites W2051385458 @default.
- W1987126916 cites W2053878919 @default.
- W1987126916 cites W2054247860 @default.
- W1987126916 cites W2059352117 @default.
- W1987126916 cites W2063692247 @default.
- W1987126916 cites W2075266360 @default.
- W1987126916 cites W2087660971 @default.
- W1987126916 cites W2087676876 @default.
- W1987126916 cites W2090895449 @default.
- W1987126916 cites W2093514870 @default.
- W1987126916 cites W2100260123 @default.
- W1987126916 cites W2100611021 @default.
- W1987126916 cites W2126514623 @default.
- W1987126916 cites W2126818857 @default.
- W1987126916 cites W2133996152 @default.
- W1987126916 cites W2136376193 @default.
- W1987126916 cites W2136550218 @default.
- W1987126916 cites W2141127908 @default.
- W1987126916 cites W2143373379 @default.
- W1987126916 cites W2144171223 @default.
- W1987126916 cites W2147062889 @default.
- W1987126916 cites W2147114673 @default.
- W1987126916 cites W2149149019 @default.
- W1987126916 cites W2150418339 @default.
- W1987126916 cites W2159447484 @default.
- W1987126916 cites W2165794397 @default.
- W1987126916 cites W2172148458 @default.
- W1987126916 cites W2344579286 @default.
- W1987126916 cites W4213141530 @default.
- W1987126916 doi "https://doi.org/10.1002/glia.1116" @default.
- W1987126916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11746766" @default.
- W1987126916 hasPublicationYear "2001" @default.
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