Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987126957> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1987126957 abstract "The study was aimed to identify factors affecting sirolimus apparent clearance (CL/F) in de novo heart transplant recipients using a population pharmacokinetic approach. A total of 31 patients (7 female and 24 male) originally included in a formal clinical trial, contributed 524 sirolimus blood concentrations with the time after dose ranging from 11.08 to 31.83 hours. Sirolimus concentrations were measured using liquid chromatography-tandem mass spectrometry and data analysis was carried out using NONMEM (Globomax LLC, Hanover, MD) software. Factors screened included age, weight, gender, primary diagnosis, biochemical and hematological indices, cyclosporine dose, days post-transplant and potential interacting medications. The predictive performance of the final model was evaluated using a data-splitting method. Sirolimus apparent clearance (CL/F) was decreased by 20.8% for every 100-mg increase in cyclosporine daily dose and was 62.1% lower in patients with primary diagnosis of ischemic heart disease (IHD). Sirolimus apparent clearance was 37.8% lower when triglyceride was greater than 2 mmol/L. Based on the final model, the average values for sirolimus CL/F and apparent volume of distribution were 7.09 and 1,350 L/h, respectively. Inter-subject variability in CL/F was 27.5% and residual random error was 24.1%. This study identified cyclosporine dose, hypertriglyceridemia and primary diagnosis of IHD as the most important factors affecting sirolimus CL/F. This information may assist in dose individualization of sirolimus in transplant recipients." @default.
- W1987126957 created "2016-06-24" @default.
- W1987126957 creator A5050578556 @default.
- W1987126957 creator A5063374906 @default.
- W1987126957 creator A5073502710 @default.
- W1987126957 date "2006-10-01" @default.
- W1987126957 modified "2023-09-23" @default.
- W1987126957 title "Apparent Clearance of Sirolimus in Heart Transplant Recipients: Impact of Primary Diagnosis and Serum Lipids" @default.
- W1987126957 cites W1525774039 @default.
- W1987126957 cites W1535918788 @default.
- W1987126957 cites W1964662082 @default.
- W1987126957 cites W1971855647 @default.
- W1987126957 cites W1976350400 @default.
- W1987126957 cites W1991910828 @default.
- W1987126957 cites W1995364352 @default.
- W1987126957 cites W1998150584 @default.
- W1987126957 cites W2000684894 @default.
- W1987126957 cites W2013028640 @default.
- W1987126957 cites W2022028441 @default.
- W1987126957 cites W2037217170 @default.
- W1987126957 cites W2047733833 @default.
- W1987126957 cites W2053378671 @default.
- W1987126957 cites W2062643000 @default.
- W1987126957 cites W2064380726 @default.
- W1987126957 cites W2071584624 @default.
- W1987126957 cites W2075421237 @default.
- W1987126957 cites W2080425667 @default.
- W1987126957 cites W2082009917 @default.
- W1987126957 cites W2126431533 @default.
- W1987126957 doi "https://doi.org/10.1097/01.ftd.0000246765.05248.fa" @default.
- W1987126957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17203553" @default.
- W1987126957 hasPublicationYear "2006" @default.
- W1987126957 type Work @default.
- W1987126957 sameAs 1987126957 @default.
- W1987126957 citedByCount "12" @default.
- W1987126957 countsByYear W19871269572012 @default.
- W1987126957 countsByYear W19871269572015 @default.
- W1987126957 countsByYear W19871269572017 @default.
- W1987126957 countsByYear W19871269572019 @default.
- W1987126957 countsByYear W19871269572020 @default.
- W1987126957 countsByYear W19871269572021 @default.
- W1987126957 crossrefType "journal-article" @default.
- W1987126957 hasAuthorship W1987126957A5050578556 @default.
- W1987126957 hasAuthorship W1987126957A5063374906 @default.
- W1987126957 hasAuthorship W1987126957A5073502710 @default.
- W1987126957 hasConcept C112705442 @default.
- W1987126957 hasConcept C126322002 @default.
- W1987126957 hasConcept C126894567 @default.
- W1987126957 hasConcept C2776239304 @default.
- W1987126957 hasConcept C2776919658 @default.
- W1987126957 hasConcept C2777921159 @default.
- W1987126957 hasConcept C2778163477 @default.
- W1987126957 hasConcept C2778913445 @default.
- W1987126957 hasConcept C2780272996 @default.
- W1987126957 hasConcept C2908647359 @default.
- W1987126957 hasConcept C71924100 @default.
- W1987126957 hasConcept C90924648 @default.
- W1987126957 hasConcept C98274493 @default.
- W1987126957 hasConcept C99454951 @default.
- W1987126957 hasConceptScore W1987126957C112705442 @default.
- W1987126957 hasConceptScore W1987126957C126322002 @default.
- W1987126957 hasConceptScore W1987126957C126894567 @default.
- W1987126957 hasConceptScore W1987126957C2776239304 @default.
- W1987126957 hasConceptScore W1987126957C2776919658 @default.
- W1987126957 hasConceptScore W1987126957C2777921159 @default.
- W1987126957 hasConceptScore W1987126957C2778163477 @default.
- W1987126957 hasConceptScore W1987126957C2778913445 @default.
- W1987126957 hasConceptScore W1987126957C2780272996 @default.
- W1987126957 hasConceptScore W1987126957C2908647359 @default.
- W1987126957 hasConceptScore W1987126957C71924100 @default.
- W1987126957 hasConceptScore W1987126957C90924648 @default.
- W1987126957 hasConceptScore W1987126957C98274493 @default.
- W1987126957 hasConceptScore W1987126957C99454951 @default.
- W1987126957 hasLocation W19871269571 @default.
- W1987126957 hasLocation W19871269572 @default.
- W1987126957 hasOpenAccess W1987126957 @default.
- W1987126957 hasPrimaryLocation W19871269571 @default.
- W1987126957 hasRelatedWork W1987705191 @default.
- W1987126957 hasRelatedWork W1995513705 @default.
- W1987126957 hasRelatedWork W2020252702 @default.
- W1987126957 hasRelatedWork W2039830992 @default.
- W1987126957 hasRelatedWork W2045224469 @default.
- W1987126957 hasRelatedWork W2064181173 @default.
- W1987126957 hasRelatedWork W2087821742 @default.
- W1987126957 hasRelatedWork W2899084033 @default.
- W1987126957 hasRelatedWork W2945177747 @default.
- W1987126957 hasRelatedWork W4226109550 @default.
- W1987126957 isParatext "false" @default.
- W1987126957 isRetracted "false" @default.
- W1987126957 magId "1987126957" @default.
- W1987126957 workType "article" @default.