Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987137112> ?p ?o ?g. }
- W1987137112 endingPage "622" @default.
- W1987137112 startingPage "611" @default.
- W1987137112 abstract "In primary headaches, there is a clear association between the headache and the release of calcitonin gene-related peptide (CGRP) but not with any of the other neuronal messengers. The purpose of this review is to describe the role of CGRP in the intracranial circulation and to elucidate a possible role for a specific CGRP receptor antagonist in the treatment of primary headaches. Acute treatment with a 5-HT(1B/1D) agonist (triptan) results in alleviation of the headache and normalization of the cranial venous CGRP levels, in part due to a presynaptic inhibitory effect on sensory nerves. The central role of CGRP in migraine and cluster headache pathophysiology has led to the search for small molecule CGRP antagonists with few cardiovascular side-effects. The initial pharmacological profile of such a group of compounds has recently been disclosed. One of these compounds has been found to be efficacious in the relief of acute attacks of migraine." @default.
- W1987137112 created "2016-06-24" @default.
- W1987137112 creator A5084413123 @default.
- W1987137112 date "2004-08-01" @default.
- W1987137112 modified "2023-10-17" @default.
- W1987137112 title "Blockade of CGRP Receptors in the Intracranial Vasculature: A New Target in the Treatment of Headache" @default.
- W1987137112 cites W1588557655 @default.
- W1987137112 cites W1965570053 @default.
- W1987137112 cites W1966878905 @default.
- W1987137112 cites W1967348361 @default.
- W1987137112 cites W1968465725 @default.
- W1987137112 cites W1970740293 @default.
- W1987137112 cites W1975097170 @default.
- W1987137112 cites W1978540371 @default.
- W1987137112 cites W1978634747 @default.
- W1987137112 cites W1979154579 @default.
- W1987137112 cites W1979959776 @default.
- W1987137112 cites W1981578013 @default.
- W1987137112 cites W1982110011 @default.
- W1987137112 cites W1982850380 @default.
- W1987137112 cites W1988441237 @default.
- W1987137112 cites W1989037231 @default.
- W1987137112 cites W1989074995 @default.
- W1987137112 cites W1992192851 @default.
- W1987137112 cites W1994194545 @default.
- W1987137112 cites W1994401085 @default.
- W1987137112 cites W1995586699 @default.
- W1987137112 cites W1995819853 @default.
- W1987137112 cites W1997717056 @default.
- W1987137112 cites W2005197501 @default.
- W1987137112 cites W2014348068 @default.
- W1987137112 cites W2014783235 @default.
- W1987137112 cites W2017208290 @default.
- W1987137112 cites W2019591295 @default.
- W1987137112 cites W2021870026 @default.
- W1987137112 cites W2023749729 @default.
- W1987137112 cites W2025701942 @default.
- W1987137112 cites W2027121504 @default.
- W1987137112 cites W2028482996 @default.
- W1987137112 cites W2029253166 @default.
- W1987137112 cites W2030058208 @default.
- W1987137112 cites W2033066280 @default.
- W1987137112 cites W2035581625 @default.
- W1987137112 cites W2036134790 @default.
- W1987137112 cites W2036187691 @default.
- W1987137112 cites W2036874023 @default.
- W1987137112 cites W2037879100 @default.
- W1987137112 cites W2038078887 @default.
- W1987137112 cites W2039523986 @default.
- W1987137112 cites W2040875763 @default.
- W1987137112 cites W2048132386 @default.
- W1987137112 cites W2048803971 @default.
- W1987137112 cites W2052850366 @default.
- W1987137112 cites W2055122753 @default.
- W1987137112 cites W2055494598 @default.
- W1987137112 cites W2056435956 @default.
- W1987137112 cites W2060012388 @default.
- W1987137112 cites W2060126485 @default.
- W1987137112 cites W2060292085 @default.
- W1987137112 cites W2062055175 @default.
- W1987137112 cites W2062714491 @default.
- W1987137112 cites W2063230662 @default.
- W1987137112 cites W2063644292 @default.
- W1987137112 cites W2063650215 @default.
- W1987137112 cites W2066080151 @default.
- W1987137112 cites W2066482395 @default.
- W1987137112 cites W2068681418 @default.
- W1987137112 cites W2069950730 @default.
- W1987137112 cites W2075243697 @default.
- W1987137112 cites W2077333621 @default.
- W1987137112 cites W2079044122 @default.
- W1987137112 cites W2079158091 @default.
- W1987137112 cites W2079612751 @default.
- W1987137112 cites W2080232509 @default.
- W1987137112 cites W2081968925 @default.
- W1987137112 cites W2083516978 @default.
- W1987137112 cites W2083821823 @default.
- W1987137112 cites W2083877101 @default.
- W1987137112 cites W2084093310 @default.
- W1987137112 cites W2084359213 @default.
- W1987137112 cites W2085595272 @default.
- W1987137112 cites W2086564877 @default.
- W1987137112 cites W2087994192 @default.
- W1987137112 cites W2088140146 @default.
- W1987137112 cites W2090402417 @default.
- W1987137112 cites W2090723133 @default.
- W1987137112 cites W2095498092 @default.
- W1987137112 cites W2102586629 @default.
- W1987137112 cites W2111112233 @default.
- W1987137112 cites W2116001754 @default.
- W1987137112 cites W2117309485 @default.
- W1987137112 cites W2137521046 @default.
- W1987137112 cites W2138814983 @default.
- W1987137112 cites W2139805099 @default.
- W1987137112 cites W2147917012 @default.
- W1987137112 cites W2149250228 @default.
- W1987137112 cites W2152730613 @default.
- W1987137112 cites W2152848856 @default.