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- W1987137464 endingPage "416" @default.
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- W1987137464 abstract "Bone contains several growth factors, including bone morphogenetic proteins (BMPs), transforming growth factor beta (TGF-beta), insulin-like growth factors I and II (IGF-I and IGF-II), platelet derived growth factor (PDGF) and basic and acidic fibroblast growth factor (bFGF and aFGF). Spatial and temporal variations in the expression and secretion of the various growth factors have been demonstrated in osteoblastic cultures and in various experimental and clinical in vivo models, including fracture healing in humans. Local application of various growth factors influences proliferation, differentiation and protein synthesis in osteoblastic cultures and bone formation in different animal models, including experimental fractures and skeletal defects. The BMPs are the only growth factors known to provoke bone formation heterotopically by making undifferentiated mesenchymal cells differentiate into osteoblasts (osteoinduction). BMPs and other growth factors, soon to become commercially available for clinical use, need a delivery system for their sustained release, as the factors are otherwise rapidly absorbed. Some existing systems inhibit bone formation by inducing chronic inflammation or physically by unresorbed carrier obstructing bone formation. New delivery systems are being investigated." @default.
- W1987137464 created "2016-06-24" @default.
- W1987137464 creator A5000372714 @default.
- W1987137464 date "1998-12-22" @default.
- W1987137464 modified "2023-10-08" @default.
- W1987137464 title "Growth factors in bone" @default.
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- W1987137464 doi "https://doi.org/10.1007/s002640050290" @default.
- W1987137464 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3619673" @default.
- W1987137464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10093814" @default.
- W1987137464 hasPublicationYear "1998" @default.
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