FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987138872> ?p ?o ?g. }

• W1987138872 endingPage "479" @default.
• W1987138872 startingPage "469" @default.
• W1987138872 abstract "Syntaxin-11 is a member of a family of membrane-trafficking proteins referred to as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). Recent studies have shown that syntaxin-11 is expressed in natural killer cells and cytotoxic T cells and is likely to play a role in the granule exocytosis pathway. However, the biological role of syntaxin-11 in other immune cells has remained elusive. This study found that stimulation with interferon-gamma upregulated syntaxin-11 expression in primary monocytes. Experiments using monocytes from patients with familial haemophagocytic lymphohistiocytosis harbouring mutations in the gene encoding syntaxin-11 (STX11), or monocytes from healthy individuals in which syntaxin-11 was downregulated using specific short-interfering RNA, demonstrated that syntaxin-11 was not required for antibody-dependent cellular cytotoxicity. On the other hand, silencing of syntaxin-11 expression in primary macrophages enhanced the phagocytosis of apoptotic target cells with a concomitant increase in macrophage secretion of tumour necrosis factor-alpha. Moreover, Fcgamma-receptor-mediated uptake of target cells was also enhanced following silencing of syntaxin-11 expression in macrophages. In addition, syntaxin-11 localized to the plasma membrane in macrophages ingesting apoptotic cell corpses. Syntaxin-11 thus appears to act as a negative regulator of human macrophage engulfment of apoptotic cells and IgG-opsonized red blood cells." @default.
• W1987138872 created "2016-06-24" @default.
• W1987138872 creator A5003243714 @default.
• W1987138872 creator A5022577576 @default.
• W1987138872 creator A5030050478 @default.
• W1987138872 creator A5043168624 @default.
• W1987138872 creator A5056275071 @default.
• W1987138872 creator A5062346307 @default.
• W1987138872 creator A5078627198 @default.
• W1987138872 creator A5090715353 @default.
• W1987138872 date "2008-07-08" @default.
• W1987138872 modified "2023-10-17" @default.
• W1987138872 title "Syntaxin-11 is expressed in primary human monocytesmacrophages and acts as a negative regulator of macrophage engulfment of apoptotic cells and IgG-opsonized target cells" @default.
• W1987138872 cites W1550337486 @default.
• W1987138872 cites W1550495414 @default.
• W1987138872 cites W1551106278 @default.
• W1987138872 cites W1556541026 @default.
• W1987138872 cites W161302449 @default.
• W1987138872 cites W1634711419 @default.
• W1987138872 cites W1965316310 @default.
• W1987138872 cites W1968442371 @default.
• W1987138872 cites W1975417922 @default.
• W1987138872 cites W1983067071 @default.
• W1987138872 cites W1986344524 @default.
• W1987138872 cites W1989953492 @default.
• W1987138872 cites W1996120942 @default.
• W1987138872 cites W2000302106 @default.
• W1987138872 cites W2006892077 @default.
• W1987138872 cites W2022501656 @default.
• W1987138872 cites W2022874065 @default.
• W1987138872 cites W2029177493 @default.
• W1987138872 cites W2042814878 @default.
• W1987138872 cites W2047422738 @default.
• W1987138872 cites W2049678425 @default.
• W1987138872 cites W2071660638 @default.
• W1987138872 cites W2095537212 @default.
• W1987138872 cites W2137809238 @default.
• W1987138872 cites W2142154309 @default.
• W1987138872 cites W2147102470 @default.
• W1987138872 cites W2147858442 @default.
• W1987138872 cites W2155132039 @default.
• W1987138872 cites W2160668997 @default.
• W1987138872 cites W2163365124 @default.
• W1987138872 cites W2166086043 @default.
• W1987138872 cites W2167148646 @default.
• W1987138872 cites W216894380 @default.
• W1987138872 cites W2170959088 @default.
• W1987138872 cites W2766739355 @default.
• W1987138872 cites W4235300003 @default.
• W1987138872 cites W4252859460 @default.
• W1987138872 doi "https://doi.org/10.1111/j.1365-2141.2008.07191.x" @default.
• W1987138872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18547321" @default.
• W1987138872 hasPublicationYear "2008" @default.
• W1987138872 type Work @default.
• W1987138872 sameAs 1987138872 @default.
• W1987138872 citedByCount "30" @default.
• W1987138872 countsByYear W19871388722012 @default.
• W1987138872 countsByYear W19871388722013 @default.
• W1987138872 countsByYear W19871388722014 @default.
• W1987138872 countsByYear W19871388722015 @default.
• W1987138872 countsByYear W19871388722016 @default.
• W1987138872 countsByYear W19871388722018 @default.
• W1987138872 countsByYear W19871388722019 @default.
• W1987138872 countsByYear W19871388722020 @default.
• W1987138872 countsByYear W19871388722021 @default.
• W1987138872 countsByYear W19871388722022 @default.
• W1987138872 crossrefType "journal-article" @default.
• W1987138872 hasAuthorship W1987138872A5003243714 @default.
• W1987138872 hasAuthorship W1987138872A5022577576 @default.
• W1987138872 hasAuthorship W1987138872A5030050478 @default.
• W1987138872 hasAuthorship W1987138872A5043168624 @default.
• W1987138872 hasAuthorship W1987138872A5056275071 @default.
• W1987138872 hasAuthorship W1987138872A5062346307 @default.
• W1987138872 hasAuthorship W1987138872A5078627198 @default.
• W1987138872 hasAuthorship W1987138872A5090715353 @default.
• W1987138872 hasBestOaLocation W19871388721 @default.
• W1987138872 hasConcept C153911025 @default.
• W1987138872 hasConcept C160448771 @default.
• W1987138872 hasConcept C175969161 @default.
• W1987138872 hasConcept C185592680 @default.
• W1987138872 hasConcept C22615655 @default.
• W1987138872 hasConcept C2778256703 @default.
• W1987138872 hasConcept C49039625 @default.
• W1987138872 hasConcept C54009773 @default.
• W1987138872 hasConcept C54355233 @default.
• W1987138872 hasConcept C55493867 @default.
• W1987138872 hasConcept C79061702 @default.
• W1987138872 hasConcept C81885089 @default.
• W1987138872 hasConcept C86803240 @default.
• W1987138872 hasConcept C95444343 @default.
• W1987138872 hasConceptScore W1987138872C153911025 @default.
• W1987138872 hasConceptScore W1987138872C160448771 @default.
• W1987138872 hasConceptScore W1987138872C175969161 @default.
• W1987138872 hasConceptScore W1987138872C185592680 @default.
• W1987138872 hasConceptScore W1987138872C22615655 @default.
• W1987138872 hasConceptScore W1987138872C2778256703 @default.
• W1987138872 hasConceptScore W1987138872C49039625 @default.
• W1987138872 hasConceptScore W1987138872C54009773 @default.

• next