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- W1987144611 abstract "Abnormalities of chromosome 1 are among the most frequent chromosomal alterations in multiple myeloma (MM), being found in up to 45% of patients.1, 2 It has been reported that the short arm of chromosome 1 is preferentially involved in deletions, whereas the long arm is associated with amplification. The gain of 1q (1q/gain) can occur as isochromosomes, duplications or jumping translocations. It has been widely reported that 1q/gain MM patients are characterized by complex karyotypes and aggressive disease, and a close association with poor-risk genetic features, such as chromosome 13q deletion (13) and the t(4;14) translocation has also been described.1 It has been recently demonstrated that gains/amplification of 1q21 increase as the condition goes from smoldering to overt MM, thus suggesting that these regions contain critical genes for disease progression.2 These findings along with the limited information concerning specific transcriptional profiles prompted us to molecularly characterize 1q/gain MMs by FISH and microarray analyses." @default.
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- W1987144611 date "2007-02-22" @default.
- W1987144611 modified "2023-10-14" @default.
- W1987144611 title "Transcriptional features of multiple myeloma patients with chromosome 1q gain" @default.
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- W1987144611 doi "https://doi.org/10.1038/sj.leu.2404616" @default.
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